Integrase inhibitor regimen showed non-inferiority and fewer adverse events versus boosted protease inhibitor in advanced HIV
Integrase Inhibitors Show Lower Event Rates Than Boosted Protease Inhibitors in Advanced HIV
This trial compared an integrase inhibitor regimen with a boosted protease inhibitor regimen in therapy-naive adults with advanced HIV disea…
A trial of 447 therapy-naive adults with advanced HIV found fewer drug-related side effects with an integrase inhibitor regimen compared to …
Enhanced CRE prevention program reduced CRE acquisition incidence in adults with risk factors compared to standard care
New ward rules may lower dangerous bacteria spread in hospitals
This cluster-randomized controlled trial evaluated an enhanced CRE prevention program in 363 adults with at least one CRE risk factor across…
A new hospital ward program using staff alerts and education may help stop the spread of dangerous resistant bacteria among patients.
Positive in vitro interactions with β-lactam linked to lower 14-day mortality in MRSA bacteraemia
Positive lab interactions linked to lower early death in MRSA infection treatment
This post hoc analysis of a multicentre randomized trial included 150 adults with MRSA bacteraemia.
When lab tests showed bacteria died better with combined drugs, patients had lower early death rates. This finding suggests smarter drug pai…
CRS3123 shows efficacy in phase 2 trial for Clostridioides difficile infection
Early trial shows CRS3123 matches vancomycin for treating C. diff infection
This phase 2 randomized trial compared CRS3123 with vancomycin in 43 adults with CDI.
A small Phase 2 trial found CRS3123 worked as well as vancomycin for curing C. diff infection in adults with their first episode or recurren…
Early-oral antibiotics showed safety superiority and efficacy equivalence versus IV-only in patients requiring prolonged therapy
Switching to oral antibiotics early cut side effects for rural patients
This randomized controlled trial evaluated patients requiring two or more weeks of IV antibiotics for infections excluding central nervous s…
Patients needing IV antibiotics for weeks had fewer side effects when they switched to oral meds early. This trial in a rural health system …
Nicotinic partial agonists show no effect on opioid use in HIV-positive smokers
New data on nicotine treatment for HIV patients who use opioids
This secondary analysis of a randomized trial in 97 HIV-positive smokers with risky alcohol use and baseline opioid use found no significant…
A new look at nicotine treatment for HIV patients who use opioids found no difference in opioid use between two drug groups.
Agricultural livelihood intervention reduced food insecurity among food insecure women with HIV in Kenya
Training women in farming skills reduced hunger for pregnant and non-pregnant HIV patients in Kenya
This secondary analysis of a cluster-randomized controlled trial evaluated an agricultural livelihood intervention among 396 food insecure w…
Agricultural training helped food-insecure women with HIV in Kenya eat better, even when they became pregnant during the study.
Target trial emulation in Johannesburg shows dolutegravir associated with greater weight and blood pressure increases versus efavirenz
New HIV drug linked to higher weight and blood pressure in South Africa
This target trial emulation compared dolutegravir to efavirenz in 2930 treatment-naive individuals in Johannesburg, South Africa.
People starting a new HIV drug in South Africa gained more weight and saw higher blood pressure than those on an older treatment.
Digital chest radiography with CAD shows variable sensitivity for asymptomatic tuberculosis in South African adults
Digital scans miss many silent tuberculosis cases in South Africa adults
This cohort study evaluated digital chest radiography (dCXR) read by blinded human readers and qXR CAD in 1353 adults in South Africa.
New data from South Africa shows digital scans and computer tools miss many silent tuberculosis cases, raising questions about current scree…
Shorter antibiotic courses may match longer ones for canine pneumonia, but evidence is weak
Shorter antibiotic courses work just as well as longer ones for dog pneumonia
This systematic review and meta-analysis of 74 dogs found no significant difference in treatment success between shorter (10-14 days) and lo…
A new analysis suggests shorter antibiotic courses may treat dog pneumonia just as well as longer ones, though evidence for cats is missing.
Narrative review of Shenfu Injection for sepsis-induced gastrointestinal injury and septic shock
A Chinese herbal therapy may protect the gut during septic shock
This narrative review examines Shenfu Injection for sepsis-induced acute gastrointestinal injury and septic shock.
A traditional Chinese herbal blend may help protect the gut during septic shock, offering a new angle on a deadly complication that often go…
Systematic review and meta-analysis finds subtyping methods linked to HIV recombinant form prevalence
New HIV variants hide in plain sight due to testing limits
This systematic review and meta-analysis of over 400 peer-reviewed studies examines HIV subtype prevalence and subtyping methodologies.
Scientists found that how we test for HIV changes what we think we know about new virus forms.