HBeAg seroclearance in HBeAg-positive chronic hepatitis B correlates with disease remission and reduced hepatocellular carcinoma risk
Clearing HBeAg helps manage chronic hepatitis B and liver risk
This systematic review examines the clinical significance and optimization strategies of HBeAg seroclearance in patients with HBeAg-positive…
Achieving HBeAg seroclearance in patients with chronic hepatitis B can lead to disease remission and a lower risk of developing liver cancer…
Klebsiella pneumoniae shows 44% pooled prevalence of antibiotic resistance in Burkina Faso healthcare settings
Antibiotic-resistant Klebsiella pneumoniae found in 44% of Burkina Faso cases
This systematic review and meta-analysis evaluates the phenotypic and molecular resistance of Klebsiella pneumoniae in healthcare settings i…
A new analysis finds 44% of Klebsiella pneumoniae infections in Burkina Faso hospitals resist antibiotics, with 85% resistant to penicillin.
6-month bedaquiline, linezolid, delamanid, and levofloxacin or clofazimine regimen is noninferior to 9-month standard care
Trial shows shorter treatment works for resistant tuberculosis
This Phase 3 randomized controlled noninferiority trial evaluated a 6-month treatment strategy for pulmonary rifampicin-resistant tuberculos…
A new six-month treatment plan for drug-resistant tuberculosis showed similar success rates to the standard nine-month course.
Doravirine and islatravir combination shows reduced virological failure risk in adults with HIV-1
Trial shows doravirine and islatravir reduce HIV-1 treatment failure
This meta-analysis evaluated the efficacy of a doravirine and islatravir regimen compared to standard triple option therapy for patients liv…
A new two-drug combination for HIV-1 shows a significantly lower risk of treatment failure compared to standard triple therapy.
Berberine reduces weight, lipids in schizophrenia with metabolic syndrome: meta-analysis
Berberine may improve weight and cholesterol in schizophrenia patients
This meta-analysis of 3 RCTs (233 patients) found that adjunctive berberine significantly reduced body weight, BMI, waist circumference, tot…
Adding berberine to treatment could help people with schizophrenia manage weight, waist size, and cholesterol levels.
Climate change drives increased frequency of vector-borne diseases through expansion of endemic areas
Climate change increases risk of heart and respiratory diseases
This narrative review synthesizes the public health consequences of global warming and climate change. The authors argue that rising tempera…
Rising global temperatures are expanding the reach of infectious diseases and creating new risks for heart, lung, and mental health.
Sugar acts as a pivotal ecological factor influencing metabolism, biofilm formation, and interspecies interactions in dental caries
New Strategies Help Prevent Dental Caries Through Ecological Management
This narrative review explores the role of dietary sugars and various prevention strategies like fluoride application and probiotics in mana…
Sugar plays a major role in how bacteria build plaque on teeth, but new strategies like probiotics and fluoride may help balance the oral mi…
Computational strategies facilitate identification of conserved antigens and potential therapeutics in parasitic diseases
Computational Tools Help Identify New Treatments for Parasitic Diseases
This systematic review evaluates the role of computational methods including genomics, proteomics, and artificial intelligence in parasitolo…
New computer-based methods are helping scientists find new ways to treat parasitic diseases by identifying drug targets and vaccine markers.
Gram-negative organisms and multidrug resistance are prevalent in dental unit waterlines
Bacteria in dental water lines show resistance to common antibiotics
This scoping review of 18 studies identifies a prevalence of Gram-negative organisms, such as Pseudomonas spp., in dental unit waterlines. T…
Research shows that bacteria found in dental unit waterlines can resist several common types of antibiotics used to treat infections.
No risk score outperformed WHO IMCI criteria for predicting pediatric pneumonia mortality
Risk Scores Do Not Outperform Standard Care for Pneumonia
This secondary analysis of a randomized controlled trial evaluated five risk scores in 1010 children with pneumonia across five African coun…
New analysis shows standard clinical tools are just as effective as complex risk scores for predicting pneumonia outcomes in children.
Mycobacteriophages show promise for drug-resistant mycobacterial infections in One Health approach
Phages Show Promise for Drug-Resistant Infections
This systematic review examines mycobacteriophages as tools for drug-resistant mycobacterial infections. The authors find them promising for…
Viruses that attack bacteria could help diagnose and treat hard-to-cure infections in people, animals, and the environment.
FDA Approves Zyvox (linezolid) for Gram-Positive Infections Including MRSA
FDA approves new antibiotic Zyvox for serious bacterial infections.
FDA approved Zyvox (linezolid) for nosocomial pneumonia, community-acquired pneumonia, complicated and uncomplicated skin infections, and va…
The FDA has approved Zyvox (linezolid) to treat serious infections caused by Gram-positive bacteria, including pneumonia and skin infections…