LC16m8 pre-exposure prophylaxis showed no mpox cases in a randomized controlled trial of high-risk adults
Mpox Vaccine Shows Promise for High-Risk Groups, But Key Questions Remain
This randomized controlled trial enrolled 570 participants in an early-vaccination group and 565 in a late-vaccination group. No mpox cases …
A new mpox vaccine produced strong immune responses in high-risk individuals, including those with HIV, but researchers still can't say for …
Systematic review finds oral probiotics decrease GBS colonization in pregnant people with variability
Probiotics Cut Group B Strep in Pregnancy New Research Reveals Real Hope
This systematic review and meta-analysis of 14 randomized controlled clinical trials evaluated oral probiotic administration versus placebo …
• Probiotics lower dangerous Group B Strep in pregnant people • Helps moms avoid antibiotics during delivery • Not ready for doctors to pres…
Pitavastatin lowers LDL and MACE risk in people with HIV on stable antiretroviral therapy
This cholesterol drug cuts heart risk for people with HIV
This secondary analysis of a phase 3 trial examined pitavastatin versus placebo in people with HIV aged 40 to 75 years on stable antiretrovi…
A large trial found that a daily statin cut heart risk by more than a third in people with HIV, even when their cholesterol looked fine.
Procalcitonin-guided care in sepsis shows no difference in early antibiotic initiation but lower 28-day mortality
A simple test in emergency rooms may lower death rates for sepsis patients
This phase 3 randomised controlled trial in 7667 patients with suspected sepsis across 20 English and Welsh emergency departments compared p…
A new test used to guide treatment for sepsis in emergency rooms lowered death rates without changing how quickly antibiotics were given.
Polymyxin B haemoadsorption associated with lower mortality in endotoxic septic shock patients
Polymyxin B blood filter cuts death risk in severe septic shock
This phase 3 trial examined polymyxin B haemoadsorption versus standard care in adults with endotoxic septic shock and multiorgan dysfunctio…
A blood filter that removes toxins may cut deaths in adults with severe septic shock, new trial results suggest.
Meta-analysis shows association between adequate antimicrobial therapy and reduced hospital length of stay
Right Antibiotic Choice Cuts Hospital Stay by Nearly Two Weeks
This meta-analysis of 4158 adult hospitalised patients examines the relationship between adequate empirical antibiotic therapy and clinical …
Choosing the right antibiotic from the start can cut a hospital stay by nearly two weeks for adults with serious infections.
Network meta-analysis compares biologics and targeted drugs for systemic lupus erythematosus efficacy and safety
New Lupus Treatments Show Stronger Results With Fewer Side Effects
This systematic review and network meta-analysis of 17,121 patients with systemic lupus erythematosus compared biologics and targeted small …
Certain new lupus drugs help more people feel better with fewer flare-ups, especially those struggling with rashes or joint pain that older …
Dental antibiotic prophylaxis does not reduce periprosthetic joint infection risk in total joint arthroplasty patients
Routine dental antibiotics do not lower infection risk for joint replacement patients
This systematic review and meta-analysis evaluated 157466 adult patients who had total joint arthroplasty undergoing dental procedures.
A massive review of over 157,000 patients found that taking antibiotics before dental work does not reduce infection risk for those with joi…
Dual antibiotic-loaded bone cement reduces surgical site infection risk in cemented hip arthroplasty patients compared to single cement
Dual antibiotic cement cuts infection risk for hip surgery patients
This systematic review and meta-analysis evaluated dual antibiotic-loaded bone cement versus single antibiotic-loaded bone cement in patient…
A large analysis shows dual antibiotic-loaded bone cement significantly lowers surgical site infection risk compared to single antibiotic ve…
Multicomponent psychosocial interventions improve antiretroviral therapy adherence in people with HIV
Multicomponent support boosts HIV medicine taking for people living with the virus
This systematic review and network meta-analysis evaluated psychosocial interventions for people with HIV.
A large review found that multicomponent psychosocial interventions significantly improved antiretroviral therapy adherence in people with H…
Tenofovir Disoproxil Fumarate in Maternal ART Linked to Modest Creatinine Decline in HIV-Positive Women
Women on TDF-based HIV meds showed kidney changes compared to infant-only treatment
This randomized trial compared tenofovir disoproxil fumarate (TDF)-containing maternal antiretroviral therapy (ART) with infant nevirapine p…
Women taking TDF-based HIV meds had larger drops in kidney function than those on infant-only treatment, but calcium and phosphate levels st…
HIV-1 resistance patterns vary by prior regimen and geographic region in this substudy
HIV drug resistance patterns vary by region and prior treatment history
This substudy examined HIV-1 drug resistance mutations in people failing first-line therapy across 14 countries.
HIV drug resistance varies by region and prior treatment. Subtype C dominates, but resistance to common drugs is high. This matters for choo…