Valacyclovir No Better Than Placebo for Stromal Keratitis in Herpes Zoster Ophthalmicus
Oral antivirals do not prevent eye inflammation in shingles patients
This secondary analysis of a randomized trial in 527 patients with herpes zoster ophthalmicus found that oral valacyclovir 1 g daily did not…
A study of 527 people with shingles eye infections found oral antivirals did not stop inflammation. Close monitoring and low-potency steroid…
Meta-analysis finds antibiotic prophylaxis reduces post-ERCP infections in biliary obstruction
Antibiotics Lower Infection Risk After ERCP Procedures
This systematic review and meta-analysis of 2105 patients found that prophylactic antibiotics significantly reduce infectious complications …
New data shows taking antibiotics before ERCP lowers infection risk for all patients with blocked bile ducts.
Meta-analysis: Nitazoxanide triple therapy improves H. pylori eradication vs standard triple therapy
Nitazoxanide triple therapy significantly improves H. pylori cure rates compared to standard treatment
This systematic review and meta-analysis of 1286 participants found that nitazoxanide-based triple therapy significantly improved H.
A large review of 1286 patients found that adding nitazoxanide to standard triple therapy significantly improved H. pylori cure rates and re…
Systematic review and meta-analysis shows cefotiam reduces postoperative infection in clean surgery
Cefotiam cuts post-surgery infection risk by half compared to no antibiotics
This systematic review and meta-analysis evaluated cefotiam prophylaxis versus no antibiotic prophylaxis or other beta-lactam agents in adul…
A large review found cefotiam lowers infection risk after clean surgery. It works as well as other common antibiotics without causing more s…
Integrase inhibitor regimen showed non-inferiority and fewer adverse events versus boosted protease inhibitor in advanced HIV
Integrase Inhibitors Show Lower Event Rates Than Boosted Protease Inhibitors in Advanced HIV
This trial compared an integrase inhibitor regimen with a boosted protease inhibitor regimen in therapy-naive adults with advanced HIV disea…
A trial of 447 therapy-naive adults with advanced HIV found fewer drug-related side effects with an integrase inhibitor regimen compared to …
Enhanced CRE prevention program reduced CRE acquisition incidence in adults with risk factors compared to standard care
New ward rules may lower dangerous bacteria spread in hospitals
This cluster-randomized controlled trial evaluated an enhanced CRE prevention program in 363 adults with at least one CRE risk factor across…
A new hospital ward program using staff alerts and education may help stop the spread of dangerous resistant bacteria among patients.
Positive in vitro interactions with β-lactam linked to lower 14-day mortality in MRSA bacteraemia
Positive lab interactions linked to lower early death in MRSA infection treatment
This post hoc analysis of a multicentre randomized trial included 150 adults with MRSA bacteraemia.
When lab tests showed bacteria died better with combined drugs, patients had lower early death rates. This finding suggests smarter drug pai…
CRS3123 shows efficacy in phase 2 trial for Clostridioides difficile infection
Early trial shows CRS3123 matches vancomycin for treating C. diff infection
This phase 2 randomized trial compared CRS3123 with vancomycin in 43 adults with CDI.
A small Phase 2 trial found CRS3123 worked as well as vancomycin for curing C. diff infection in adults with their first episode or recurren…
Early-oral antibiotics showed safety superiority and efficacy equivalence versus IV-only in patients requiring prolonged therapy
Switching to oral antibiotics early cut side effects for rural patients
This randomized controlled trial evaluated patients requiring two or more weeks of IV antibiotics for infections excluding central nervous s…
Patients needing IV antibiotics for weeks had fewer side effects when they switched to oral meds early. This trial in a rural health system …
Nicotinic partial agonists show no effect on opioid use in HIV-positive smokers
New data on nicotine treatment for HIV patients who use opioids
This secondary analysis of a randomized trial in 97 HIV-positive smokers with risky alcohol use and baseline opioid use found no significant…
A new look at nicotine treatment for HIV patients who use opioids found no difference in opioid use between two drug groups.
Agricultural livelihood intervention reduced food insecurity among food insecure women with HIV in Kenya
Training women in farming skills reduced hunger for pregnant and non-pregnant HIV patients in Kenya
This secondary analysis of a cluster-randomized controlled trial evaluated an agricultural livelihood intervention among 396 food insecure w…
Agricultural training helped food-insecure women with HIV in Kenya eat better, even when they became pregnant during the study.
Target trial emulation in Johannesburg shows dolutegravir associated with greater weight and blood pressure increases versus efavirenz
New HIV drug linked to higher weight and blood pressure in South Africa
This target trial emulation compared dolutegravir to efavirenz in 2930 treatment-naive individuals in Johannesburg, South Africa.
People starting a new HIV drug in South Africa gained more weight and saw higher blood pressure than those on an older treatment.