Cross-sectional study in South Benin finds metronidazole prescribing linked to symptoms
A Common Antibiotic Is Being Widely Prescribed — but Is It Always the Right Call?
A register-based cross-sectional study of 2,200 medical visits in South Benin primary care found metronidazole prescribing was associated wi…
In Benin, a common gut infection antibiotic is prescribed in nearly one in five clinic visits, raising urgent questions about whether it is …
Review of WGS-enabled IPC surveillance for CPE transmission in a London hospital trust
Hospital Superbugs Are Spreading Undetected — and a DNA Tool Is Changing That
This retrospective review evaluated WGS-enabled infection prevention and control surveillance in a large tertiary care hospital trust in Lon…
Hospitals miss most dangerous germ transmissions, but a new DNA tool detects outbreaks up to 47 days earlier and saves millions annually.
Development and validation study of TranScrub qPCR assay for scrub typhus diagnosis
A Deadly Fever Is Being Missed Worldwide — A New Test May Finally Catch It
This primary research article describes the development and validation of the TranScrub qPCR assay for diagnosing scrub typhus in patients w…
A new genetic test catches scrub typhus with 91% accuracy, helping doctors diagnose this deadly fever that often mimics other illnesses and …
Review of genomic surveillance finds concurrent Mpox subclade circulation across Africa
Mpox Is Spreading in Ways Scientists Didn't See Coming
This review synthesizes genomic surveillance data from 24 African Union Member States, covering 3,450 high-quality MPXV virus whole genomes.
Mpox is spreading across Africa in surprising ways, with different strains jumping from animals to people or spreading quietly between human…
Narrative review on sepsis and the microbiome, highlighting unresolved causality and variability
Could your sepsis treatment be missing a key clue about your unique biology?
This narrative review synthesizes current evidence on the microbiome in sepsis.
Sepsis treatment risks vary by biology because gut bacteria and genes drive inflammation, yet doctors currently lack tools to predict who wi…
Phase 1 cohort study assesses prophylactic pDNA vaccine safety and immunogenicity in healthy adults
Early study of a COVID-19 DNA vaccine in healthy adults showed no serious safety issues
This Phase 1 cohort study enrolled 42 eligible healthy subjects to evaluate a prophylactic COVID-19 pDNA vaccine compared to placebo (Saline…
A new COVID-19 DNA vaccine showed no serious safety issues in healthy adults after six months of monitoring.
MAIT cell frequency decreased in sepsis-related liver injury, with altered phenotype and function in murine models
Liver cells get help from immune defenders during sepsis
This observational cohort study in patients with sepsis-related liver injury (SRLI) and murine models found significantly decreased peripher…
During sepsis, immune defenders actually protect the liver instead of causing damage, offering new hope for patients losing liver function.
Biofilm-driven chronic rhinosinusitis: review reframes recalcitrance as immune and ecological dysregulation
A narrative review discusses chronic rhinosinusitis without reporting new study data or results
This narrative review reframes treatment-recalcitrant chronic rhinosinusitis (CRS) as a biofilm-driven disorder in which microbial communiti…
This document is a narrative review about chronic rhinosinusitis, a condition involving long-term inflammation of the nasal sinuses.
Review of Spatial AI combining multi-omics with deep learning for cancer biomarkers
Can AI read the hidden maps of cancer cells to find new ways to fight disease?
This narrative review examines the application of Spatial AI, specifically combining high-resolution spatial multi-omics with deep learning …
Cancer resistance hides in cell neighborhoods, not just individual cells, so new AI maps reveal how tumors organize defenses to block treatm…
tNGS in pediatric LRTIs shows higher Mycoplasma pneumoniae detection in severe vs non-severe CAP
A new test found more germs in severe pediatric pneumonia cases than mild ones
A retrospective, single-center cohort study of 2,299 children with suspected lower respiratory tract infections found that targeted next-gen…
A new test found that severe pediatric pneumonia cases carry more germs than mild ones, revealing a link between specific microbial signatur…
Insulin administration associated with lower 28-day mortality in non-diabetic sepsis patients
Insulin Might Help Sepsis Patients Survive Longer
This retrospective cohort study of 11,289 non-diabetic patients with sepsis found insulin administration was associated with reduced 28-day …
Insulin therapy was linked to a 37% lower risk of death in non-diabetic sepsis patients, though it extended hospital stays.
Plasma hyaluronic acid levels predict ARDS and intubation in adult COVID-19 patients
Could a simple blood test help predict who needs breathing support for COVID-19?
This retrospective single-center cohort study evaluated plasma hyaluronic acid (HA) levels in 502 adult patients with COVID-19.
High levels of a specific blood substance linked to severe lung trouble could help doctors spot who needs breathing support for COVID-19 soo…