Inflammation and immune dysregulation drive chronic kidney disease progression and associated tissue remodeling
Inflammation and Immune Issues Drive Chronic Kidney Disease Progression
This mini review synthesizes the role of inflammation and immune dysregulation in the initiation and progression of chronic kidney disease. …
Persistent inflammation and immune system issues are central drivers of chronic kidney disease, leading to tissue damage and potential compl…
Concurrent primary aldosteronism and micro-pheochromocytoma can coexist in patients with paroxysmal hypertension
Surgery helps woman with complex high blood pressure and tumors
This case report describes a 65-year-old woman with paroxysmal hypertension who presented with concurrent primary aldosteronism and a micro-…
A 65-year-old woman found to have two different types of adrenal gland issues was successfully treated after surgery.
Finerenone Efficacy and Safety in Patients with Chronic Kidney Disease and Glomerular Disease
Finerenone slows kidney function loss in patients with glomerular disease
Finerenone significantly slows eGFR decline and reduces albuminuria in patients with glomerular disease, offering a new therapeutic option f…
A new clinical trial shows that the medication finerenone helps slow kidney decline and reduces protein in the urine for people with specifi…
Vitamin D supplementation shows low certainty reductions in urinary markers for diabetic kidney disease
Vitamin D shows limited benefit for diabetic kidney disease
This umbrella review meta-analysis evaluates vitamin D and its analogs in patients with diabetic kidney disease. While some reduction in uri…
Vitamin D may lower protein in urine for diabetic kidney disease, but evidence is weak and no benefit for kidney function or survival.
SARS-CoV-2 related microvascular thrombosis is associated with increased risk of acute kidney injury
Small blood clots in COVID-19 patients link to kidney damage
This systematic review examines the link between SARS-CoV-2 related microvascular thrombosis and acute kidney injury in patients with COVID-…
Tiny blood clots in the small vessels of the body are linked to serious kidney damage and higher death rates in people with COVID-19.
FDA Approves Sodium Bicarbonate Injection for Metabolic Acidosis and Urinary Alkalinization
FDA approves sodium bicarbonate injection for acidosis and poisonings.
The FDA approved sodium bicarbonate injection to raise plasma pH in adults and pediatric patients with clinically significant metabolic acid…
The FDA approved a new ready-to-use sodium bicarbonate injection to treat metabolic acidosis and help remove certain drugs in poisoning case…
Renal vascular variations do not compromise long-term outcomes in patients with complex anatomy
Renal Vascular Variations Impact Surgery for Kidney Transplant Patients
This narrative review examines the impact of anatomical features, such as multiple renal arteries, on surgical management and transplant out…
Kidney transplant patients with unusual blood vessel patterns may face more complex surgeries but can still achieve successful long-term out…
Inclisiran reduces LDL cholesterol by up to 54.7% in patients with atherosclerotic cardiovascular disease
Trial shows consistent cholesterol reduction for heart disease patients
This Phase 3 randomized controlled trial evaluated inclisiran in 3,660 patients with heterozygous familial hypercholesterolemia and atherosc…
A large trial shows that a new injection can significantly lower bad cholesterol in people with high risk for heart disease.
KidneyTIME digital intervention improves knowledge and listing behaviors but not donor inquiries in kidney transplant candidates
Digital Tools Improve Knowledge for Kidney Transplant Candidates
This RCT in 422 adult kidney transplant candidates found that the KidneyTIME digital intervention did not increase live donor inquiries vers…
A new digital program helped kidney transplant candidates gain more knowledge and take action, even though it did not immediately increase d…
Respiratory viral coinfections reshape immune signaling and granuloma stability in Mycobacterium tuberculosis infections
Viral Infections May Change How the Body Fights Tuberculosis
This narrative review synthesizes how respiratory viruses, including SARS-CoV-2 and influenza, impact host immune signaling and granuloma eq…
Research shows that common respiratory viruses like flu or COVID-19 can change how the immune system responds to tuberculosis infections.
Dapagliflozin reduces proteinuria and blood pressure but does not improve eGFR in CAD patients
Trial shows dapagliflozin impacts blood pressure and protein in transplant patients
This randomized controlled trial of 208 adult kidney transplant recipients with chronic allograft dysfunction found that dapagliflozin 10 mg…
A new trial shows that the drug dapagliflozin can lower blood pressure and protein levels in kidney transplant recipients with specific comp…
Acupuncture combined with exercise rehabilitation improves cardiac function and walk distance in heart failure
Acupuncture combined with exercise may improve heart failure function
This meta-analysis of 668 patients evaluated acupuncture combined with exercise rehabilitation (ACER) versus exercise alone. The analysis fo…
Combining acupuncture with exercise training could improve heart function and walking distance for people living with heart failure.