Longitudinal multimodal MRI identifies Friedreich ataxia progression subtypes in 111 patients and controls
Three distinct brain patterns linked to Friedreich ataxia progression
This observational cohort study analyzed 111 participants, including 54 Friedreich ataxia patients and 57 controls, using longitudinal multi…
Three distinct brain patterns linked to Friedreich ataxia progression were identified using MRI scans and genetic data in patients.
CSF SAA status associates with levodopa responsiveness and motor progression in Parkinson's disease patients
Parkinson’s test predicts levodopa response and motor decline speed
This observational cohort study analyzed 223 sporadic Parkinson's disease participants from the PPMI cohort initiating levodopa.
Test reveals Parkinson’s patients with alpha-synuclein seeds respond better to levodopa and decline slower than those without the seeds.
Scoping Review Summarizes COP Biofeedback Interventions for Chronic Stroke Fall Prevention
Biofeedback Linked to Lower Fall Risk in Stroke Survivors
This scoping review synthesizes evidence from nine studies involving 306 participants regarding center of pressure interventions for adult s…
Stroke survivors face high fall rates. Biofeedback helps reduce sway and may significantly lower injury risk after discharge.
Prospective observational study of VNS in drug-resistant epilepsy patients with or without prior intracranial surgery
Failed Brain Surgery? This Device Might Still Stop Seizures
This prospective, multicenter, international observational study abstract evaluates vagus nerve stimulation (VNS) in 531 patients with drug-…
Patients who had brain surgery but still have seizures can still benefit from nerve stimulation therapy.
Secondary analysis of pooled ALS trial data reveals entropy-based functional domain trajectories
New Method Reveals Hidden Treatment Signals in ALS Trials
This secondary analysis of pooled clinical trial data from the PRO-ACT database examined Shannon entropy trajectories of ALSFRS functional d…
This study suggests that the way we measure success in ALS clinical trials might be hiding real treatment benefits, and a new mathematical a…
Retrospective review of tocilizumab, rituximab, and azathioprine in chronic relapsing inflammatory optic neuropathy
New Clue Found in Stubborn Eye Inflammation
This retrospective analysis reviews tocilizumab, rituximab, and azathioprine use in 60 patients with chronic relapsing inflammatory optic ne…
Knowing a patient's blood marker status can guide doctors to the right therapy to stop recurring eye inflammation.
Observational study finds lower delayed recall ratios in multiple sclerosis patients versus controls
Memory fades faster in multiple sclerosis, study finds
This observational study abstract compares memory recall in 127 participants, including 62 multiple sclerosis patients and 65 controls.
People with MS forget more after a week than healthy peers. A simple memory test may spot cognitive decline earlier.
Observational cohort study on smartphone-based cognitive assessment during migraine attacks
At-a-Glance
This primary research article is an observational cohort study of 139 adults with migraine using smartphone-based cognitive tasks.
This study proves that your brain's processing speed and memory can dip during a migraine attack, and a simple smartphone app can now track …
First-line suction aspiration versus combination technique for acute cerebral infarction in a multicenter trial
Imagine waking up unable to move one side of your body. This sudden loss of control is a stroke. Every minute counts when a blood vessel in the brain is blocked. Doctors race to open the vessel and save brain tissue. Time is the most important factor in recovery
This prospective, randomized, multicenter, noninferiority, open-label trial enrolled 1136 patients with acute cerebral infarction amenable t…
Strokes are a leading cause of disability worldwide.
Systematic review and meta-analysis of CBT for depression in multiple sclerosis patients
New NEJM Analysis: CBT Works for MS Depression—No Matter How You Get It
This systematic review and meta-analysis evaluated cognitive behavioral therapy (CBT) for depressive symptoms in patients with multiple scle…
This analysis proves that depression treatment for MS patients can fit their lifestyle, not the other way around.
Meta-analysis finds trivial cognitive effects of amyloid antibodies in mild Alzheimer's disease
Alzheimer’s Drugs Clear Plaques But Don’t Help Memory
This meta-analysis of 17 randomized trials found amyloid-beta-targeting monoclonal antibodies probably have little to no effect on cognitive…
This review shows that even when Alzheimer’s drugs clear amyloid from the brain, patients don’t see meaningful improvements in memory or dai…
Network meta-analysis of speech therapy for poststroke aphasia finds no single superior approach
Speech therapy improves quality of life after stroke, study finds
This network meta-analysis of randomized controlled trials in patients with poststroke aphasia synthesized evidence on speech therapy.
Speech therapy after stroke can improve quality of life, but no single approach was clearly better for language recovery in a large review.