PRNP D178N-129MM mutation presents with rapid cognitive decline and extensive cortical DWI ribboning
Mutation Linked to Rapid Cognitive Decline and Sleep Disorders
This case report and literature review describes the clinical and imaging phenotype of the PRNP D178N-129MM mutation. The authors report a c…
A rare genetic mutation is linked to rapid cognitive decline and specific sleep behaviors in patients with a fatal insomnia condition.
Multicomponent Nonpharmacological Interventions Cut Delirium Incidence in Critically Ill ICU Patients
Multi-component care helps prevent delirium in critically ill patients
This meta-analysis of randomized trials found that multicomponent nonpharmacological interventions significantly reduced delirium incidence …
A combination of non-drug treatments can significantly lower the risk of delirium for patients in intensive care units.
TCM combined with Western medicine ranks highest for insomnia improvement in network meta-analysis
Combining Traditional Chinese Medicine and Western medicine helps insomnia
This systematic review and network meta-analysis of 1,260 patients indicates that combining Traditional Chinese Medicine (TCM) with Western …
Combining Traditional Chinese Medicine with Western medicine may offer a more effective way to manage insomnia than using either treatment a…
Multidisciplinary neurorehabilitation and emerging technologies offer potential for personalized stroke recovery in elderly populations
New Technologies and Therapies Help Stroke Survivors Recover Function
This narrative review explores neurorehabilitation for stroke survivors, focusing on neural plasticity and glial cell function. It highlight…
Emerging technologies like virtual reality and robotics are being explored to help stroke survivors regain motor skills and improve their qu…
Impact of Psychosocial Stress Domains on the Incidence of First Ever Stroke
Psychosocial stress is linked to a higher risk of stroke
A large-scale meta-analysis identifies significant links between psychological, vocational, and interpersonal stressors and stroke risk.
New data suggests that psychological and work-related stress are linked to a higher risk of having a first-ever stroke.
Gut microbiota dysbiosis and increased intestinal permeability markers are associated with Parkinson's disease
Gut bacteria patterns may differ in Parkinson's disease patients
This meta-analysis of 33 human studies involving 1,588 Parkinson's disease patients and 1,449 healthy controls identifies significant altera…
New research shows specific changes in gut bacteria and intestinal barriers in people living with Parkinson's disease.
HRSN assessment tools lack sufficient psychometric testing and reliability data for geriatric populations
New Review Highlights Gaps in Alzheimer's and Dementia Care Tools
This systematic review of 7 studies evaluated the methodological rigor and psychometric properties of HRSN assessment tools in older adults.…
Current tools used to measure social needs for seniors with dementia lack enough testing to ensure they are accurate for older adults.
Immersive virtual reality yields highest effect sizes for upper limb motor function in stroke survivors
Immersive Virtual Reality Shows Promise for Stroke Recovery
This systematic review and network meta-analysis of 1,524 patients found that immersive virtual reality outperformed semi-immersive and noni…
Immersive virtual reality may offer better results for upper limb motor function and daily independence than other types of virtual reality …
Dyadic Capability Scale protocol targets stroke survivor-caregiver assessment
New Tool Planned to Measure Stroke Survivor and Caregiver Support
This is a study protocol for the development and validation of the Dyadic Capability Scale, an instrument intended to assess dyadic capabili…
A new assessment tool is being developed to help measure and improve the way caregivers and stroke survivors work together as a team.
Circulating blood biomarker families show promising but methodologically fragile signals for acute ischemic stroke diagnosis
Blood tests show promise for identifying acute ischemic stroke
This meta-analysis of 17 independent cohorts evaluates the diagnostic accuracy of extracellular chromatin, cell-free DNA, non-coding RNA, an…
New blood tests using cell-free DNA and non-coding RNA show potential for identifying stroke, though more research is needed for clinical us…
Tubulin code modifications and specific pathways influence ischemic stroke neuroprotection and cytoskeletal remodeling
Tubulin Code Research May Offer New Insights for Ischemic Stroke
This narrative review explores the role of tubulin isotype composition and post-translational modifications in ischemic stroke. The authors …
New research into the tubulin code identifies specific ways the brain's transport system changes after a stroke, potentially opening doors f…
Lysosomal enhancement via vacuolar H+-ATPase remains experimental for protein misfolding neurodegenerative diseases
Lysosome Boost May Help Misfolded Protein Diseases
This mini-review examines enhancement of lysosomal activity, including vacuolar H+-ATPase, as a therapeutic strategy for protein misfolding …
A new review explores whether boosting lysosome activity could help treat brain diseases caused by misfolded proteins.