Intracranial hemorrhage rates were higher in tenecteplase than standard care at 14.4% versus 9.2% in minor ischemic stroke
Even small bleeds after minor stroke raise death risk in this trial analysis
This secondary analysis of a multicenter randomized controlled trial evaluated 865 patients with minor ischemic stroke within 12 hours of sy…
A look at trial data shows that small bleeds after minor stroke are linked to higher death rates, even if they do not worsen long-term funct…
Extended-window alteplase increases functional outcomes but raises hemorrhage risk in acute ischemic stroke patients
Giving clot-busting drugs beyond 4.5 hours raises bleeding risk but may improve function
This meta-analysis of 2,050 adults shows intravenous alteplase beyond 4.5 hours improves functional scores but significantly increases sympt…
A large review of 2,050 stroke patients found higher bleeding risk with late clot-busting drugs, though some functional gains appeared.
QSM MRI reveals distinct iron deposition patterns differentiating Parkinsonian syndromes
Brain MRI technique may help tell apart Parkinson's and similar disorders
This systematic review and meta-analysis of 626 PD, 160 MSA, 176 PSP patients and 256 controls found that quantitative susceptibility mappin…
A special MRI can spot distinct brain iron patterns in Parkinson's and related diseases, offering a potential diagnostic tool.
Endovascular thrombectomy boosts functional independence significantly for acute ischemic stroke patients compared to medical management alone
Endovascular thrombectomy offers better recovery chances for stroke patients with large vessel blockages compared to standard medical care alone
A meta-analysis of 718 acute ischemic stroke patients found endovascular thrombectomy significantly improved functional independence versus …
A review of stroke treatments shows that removing the blockage with a catheter leads to much better recovery. This works well for patients w…
Post hoc analysis shows unsuccessful thrombectomy does not worsen outcomes for large ischemic infarcts compared to medical treatment alone
Unsuccessful clot removal did not worsen outcomes for patients with large strokes
In patients with large ischemic infarcts, unsuccessful endovascular thrombectomy did not increase mortality or worsen functional outcomes ve…
For patients with large strokes, a less successful clot removal did not lead to worse survival or function compared to medical treatment alo…
Continuous subcutaneous foslevodopa/foscarbidopa improves off time in Parkinson's disease; severe adverse events higher in prior DBS group
Patients with Parkinsons disease who had prior brain surgery saw more side effects while using new skin patches
This post hoc analysis of an open-label phase 3 trial evaluated continuous subcutaneous infusion of foslevodopa/foscarbidopa in 244 patients…
A new look at trial data shows skin patches help Parkinsons patients move better and sleep longer. However, those who had brain surgery earl…
Systematic review finds inflammatory markers elevated in Alzheimer's disease compared to healthy controls across 41 studies
Inflammatory markers linked to Alzheimer's and other dementia types
This systematic review and meta-analysis examined 41 eligible studies involving healthy controls and patients with various dementia subtypes…
A large review found that people with Alzheimer's and other dementias show higher inflammation than healthy people, though more research is …
Noninvasive brain stimulation reduces pain intensity in central poststroke pain with a pooled effect size of -0.64
Noninvasive brain stimulation reduces pain in stroke survivors but does not fix mood
This systematic review and meta-analysis evaluated noninvasive brain stimulation versus sham stimulation in patients with central poststroke…
A review of 430 patients found noninvasive brain stimulation lowers pain in central poststroke pain, though it does not improve mood or qual…
Interactive cognitive-motor training improves mobility, gait, and balance in chronic stroke
Interactive training boosts balance and movement for people with chronic stroke
This systematic review and meta-analysis of 1422 people with chronic stroke found that interactive cognitive-motor training significantly im…
A large review found interactive cognitive-motor training significantly improved balance, mobility, and gait speed for people with chronic s…
GBA1 L444P carriers have ninefold higher odds of Parkinson's disease than non-carriers
People with one GBA1 L444P gene change face much higher risk of developing Parkinson's disease compared to those without it
This systematic review and meta-analysis of 33,752 PD patients and 34,101 controls found that heterozygous GBA1 L444P carriers had markedly …
A large review of over sixty-seven thousand people found that carrying one copy of the GBA1 L444P gene change greatly increases the chance o…
Integrative brain care bundles and transdisciplinary training dismantle structural barriers in maternal-child health globally
New training bundles aim to fix fragmented brain care for mothers and babies worldwide
This narrative review examines global healthcare systems and diverse clinical settings regarding transdisciplinary fetal-neonatal neurology …
Experts suggest new training and care bundles could help integrate brain health support for mothers and infants across the globe.
Oral Semaglutide Failed to Slow Clinical Progression in Early Alzheimer's Disease Across Global Phase 3 Trials
Oral semaglutide did not slow Alzheimer's disease progression in early trials
In large phase 3 trials, oral semaglutide showed no benefit over placebo for patients with early Alzheimer's disease. The drug did not impro…
A large trial found that taking oral semaglutide offered no benefit over placebo for people with early Alzheimer's disease.