Exercise and physical activity may reduce fatigue in adults with systemic lupus erythematosus
Exercise May Help Reduce Fatigue in People with Lupus
This umbrella review evaluates exercise and physical activity for managing fatigue and disease activity in adults with systemic lupus erythe…
Exercise and physical activity may help reduce fatigue for adults with lupus, though the current evidence is limited and not yet fully certa…
Intracranial atherosclerosis contributes significantly to global ischemic stroke burden across diverse geographic regions
Understanding the Role of Intracranial Atherosclerosis in Global Stroke Cases
This systematic review of 138 studies examines the epidemiology of intracranial atherosclerosis (ICAD) and its role in ischemic stroke. Find…
Intracranial atherosclerosis is a major cause of stroke worldwide. New data shows it affects millions of people across different continents.
sc/snRNA-seq identifies disease-relevant cell states and pathophysiological processes in ischemic stroke research
New Sequencing Technology Helps Identify Stroke Treatment Targets
This systematic review examines the utility of single-cell and single-nucleus RNA sequencing (sc/snRNA-seq) in ischemic stroke research. The…
Advanced single-cell sequencing helps researchers identify specific cell types and molecular pathways involved in ischemic stroke to help gu…
PMP22 sequence variants cause HNPP through protein loss or impaired folding and trafficking
New insights into the genetic causes of pressure palsy nerve damage
This narrative review synthesizes the mechanisms of PMP22 sequence variants in hereditary neuropathy with liability to pressure palsies. It …
New research explains how specific genetic variants cause nerve damage in patients with hereditary neuropathy and pressure palsies.
Pulsed radiofrequency with nerve block improves clinical response and pain in cervical radiculopathy
Pulsed radiofrequency combined with nerve blocks improves neck pain
This meta-analysis of 783 patients found that pulsed radiofrequency combined with nerve block significantly improved overall clinical respon…
Adding pulsed radiofrequency to a nerve block may provide better pain relief and movement for people with neck nerve issues.
Non-pharmacological Parkinson's trials are broad but too heterogeneous to rank interventions
Parkinson's Motor Trials Mapped, But Which Works Remains Unclear
This scoping review maps 50 eligible reports representing 48 independent randomized trials of non-pharmacological interventions for motor fu…
A new map of 48 Parkinson's trials shows a wide range of non-drug treatments, but which ones actually work is still unclear.
Impact of Receptor Stimulating Antihypertensive Medications on Alzheimer Disease Risk in Elderly Patients
Certain blood pressure medications may link to lower dementia risk
Retrospective analysis suggests receptor-stimulating antihypertensives may correlate with lower ADRD incidence compared to receptor-inhibiti…
A large study of over 1.5 million seniors suggests specific blood pressure medications may be linked to lower rates of dementia and cognitiv…
CAR-T cell therapy shows preliminary clinical activity in refractory neuroimmune diseases
CAR-T Cell Therapy Shows Early Activity in Neuroimmune Diseases
This narrative review synthesizes current evidence on CAR-T cell therapies targeting CD19, BCMA, or dual CD19/BCMA for neuroimmune diseases.…
New CAR-T cell therapies are showing early clinical activity for patients with rare and difficult to treat neuroimmune conditions.
Sleep disturbances and obstructive sleep apnea lower seizure thresholds and impact sleep architecture in epilepsy
Sleep patterns and conditions impact seizure control in epilepsy
This narrative review explores the bidirectional relationship between epilepsy and sleep disorders. It highlights how NREM sleep promotes se…
New insights show how specific sleep stages and conditions like sleep apnea can influence seizure activity and quality of life for people wi…
Physiotherapy consistently improves balance, postural stability, and gait speed after STN deep brain stimulation
Physiotherapy Shows Promise for Parkinson's Patients After Brain Surgery
This systematic review of 10 studies indicates that physiotherapy consistently improves balance, postural stability, gait speed, and functio…
Physiotherapy may improve balance, walking speed, and mobility for Parkinson's patients who have received deep brain stimulation surgery.
MMP-3 polymorphism does not show significant association with Alzheimer's disease risk
Meta-analysis finds no link between MMP-3 gene and Alzheimer's
Researchers investigated the association between the MMP-3 -1171 5A/6A polymorphism and the risk of Alzheimer's disease. The analysis found …
A large-scale review of genetic data suggests a specific gene variation does not increase the risk of developing Alzheimer's disease.
Elevated plasma CD147 levels are associated with 1.75 odds ratio for poststroke cognitive impairment
Higher CD147 levels linked to cognitive issues after stroke
This observational study of 612 patients with ischemic stroke found that elevated plasma CD147 levels were associated with a 1.75 odds ratio…
A new look at stroke recovery shows that higher levels of a specific protein in the blood may signal a higher risk of lasting brain fog.