Six novel loci and nine recessive loci identified for young onset Parkinson's disease in European ancestry
Genetic clues to young onset Parkinson's disease found in large global study
This meta-analysis of genome-wide association studies in 1,528 patients and 20,408 controls identified six independent loci and nine recessi…
A massive analysis of genetic data found six new spots in our DNA linked to early Parkinson's disease, offering hope for better prevention a…
IBD-related neuroimaging shows brain alterations in emotional networks with distinguishable phenotypes for Crohn's and ulcerative colitis
Brain scans show different emotional patterns in Crohn's and ulcerative colitis
This bibliometric analysis and systematic scoping review examines 175 articles on IBD-related neuroimaging literature from Web of Science an…
A review of 175 articles found that brain activity in Crohn's and ulcerative colitis affects emotion centers differently. This suggests dist…
Thrombectomy plus intra-arterial alteplase increases excellent functional outcome to 57.5% at 90 days
Adding Alteplase to Thrombectomy Improves Stroke Recovery in This Trial
This randomized, open-label trial with blinded outcome assessment in 440 patients with acute ischemic stroke found that adding intra-arteria…
A Spanish trial found adding intra-arterial alteplase to thrombectomy increased excellent recovery rates without significantly raising bleed…
Ethanol exposure and high-fat diet may impair amyloid-beta clearance and promote oxidative stress in Alzheimer's disease
Ethanol and high-fat diets may worsen Alzheimer's disease markers
This narrative review examines the potential impact of ethanol exposure and high-fat diet on Alzheimer's disease pathology. The authors sugg…
A review suggests alcohol and poor diet together might increase Alzheimer's risk by damaging brain cells and boosting inflammation.
Non-invasive brain stimulation with motor imagery improves upper limb function after stroke with WMD 5.75
Non-invasive brain stimulation helps stroke patients move their arms better
This systematic review and meta-analysis of 21 studies found that non-invasive brain stimulation combined with motor imagery significantly i…
Combining brain stimulation with motor imagery significantly improves arm movement and daily tasks for stroke survivors in this analysis of …
FDA Approves Morphine Sulfate Injection for Severe Pain Requiring Opioid Analgesic
FDA approves morphine injection for severe pain when other treatments fail.
FDA approved Morphine Sulfate Injection for management of pain severe enough to require an opioid analgesic and for which alternative treatm…
The FDA approved Morphine Sulfate Injection, an opioid, for severe pain that requires an opioid and when other treatments are not enough. Th…
FDA Approves Soliris (eculizumab) for Generalized Myasthenia Gravis and NMOSD
FDA approves Soliris for two rare autoimmune diseases.
The FDA approved Soliris (eculizumab) for generalized myasthenia gravis (gMG) in anti-AChR antibody-positive patients aged 6 years and older…
The FDA approved Soliris for generalized myasthenia gravis and neuromyelitis optica spectrum disorder. These are rare conditions where the i…
Aging is associated with poorer locomotor recovery after traumatic spinal cord injury in preclinical models
Older rats recover less from spinal cord injury, but exercise helps them catch up
This systematic review of preclinical studies found that older animals demonstrate significantly lower locomotor scores after spinal cord in…
Aging makes spinal cord injury harder to recover from in rats. But exercise training can help older animals reach recovery levels similar to…
Nurse-driven service model reduces door-to-needle time by 16.72 minutes in acute ischemic stroke
Nurse-led stroke care cuts critical treatment time by minutes
This systematic review and meta-analysis evaluated quasi-experimental studies involving patients with acute ischemic stroke in an in-hospita…
A large review shows hospital nurse-led teams significantly speed up life-saving stroke treatment, reducing wait times for patients with acu…
Higher admission WBC predicts favorable methylprednisolone effect after thrombectomy
Higher white blood cell counts linked to better methylprednisolone effects in stroke patients
This secondary analysis of a randomized, placebo-controlled trial evaluated 1201 patients with anterior-circulation large-vessel occlusion s…
A secondary analysis suggests higher white blood cell counts may predict better outcomes when adding methylprednisolone to stroke treatment …
Apixaban Reduces Intracranial Bleeding Risk Compared To Aspirin In Patients With Cryptogenic Stroke And Atrial Cardiopathy Evidence
Trial shows apixaban reduces intracranial bleeding risk versus aspirin in cryptogenic stroke patients
In a multicenter randomized trial of 1,015 patients, apixaban demonstrated a significant reduction in intracranial hemorrhage compared to as…
A trial of 1,015 patients found apixaban caused fewer intracranial hemorrhages than aspirin, offering safety insights for those with cryptog…
Endovascular therapy showed no benefit over medical care alone for mild-to-moderate medium or distal vessel occlusion stroke patients in this randomized trial
Endovascular treatment offers no disability benefit for mild-to-moderate stroke patients
A randomized trial involving 543 adults with acute ischaemic stroke found that adding endovascular treatment to standard medical care did no…
A trial of 553 stroke patients found adding endovascular treatment to standard care did not reduce disability compared to medical treatment …