Aging is associated with poorer locomotor recovery after traumatic spinal cord injury in preclinical models
Older rats recover less from spinal cord injury, but exercise helps them catch up
This systematic review of preclinical studies found that older animals demonstrate significantly lower locomotor scores after spinal cord in…
Aging makes spinal cord injury harder to recover from in rats. But exercise training can help older animals reach recovery levels similar to…
Nurse-driven service model reduces door-to-needle time by 16.72 minutes in acute ischemic stroke
Nurse-led stroke care cuts critical treatment time by minutes
This systematic review and meta-analysis evaluated quasi-experimental studies involving patients with acute ischemic stroke in an in-hospita…
A large review shows hospital nurse-led teams significantly speed up life-saving stroke treatment, reducing wait times for patients with acu…
Higher admission WBC predicts favorable methylprednisolone effect after thrombectomy
Higher white blood cell counts linked to better methylprednisolone effects in stroke patients
This secondary analysis of a randomized, placebo-controlled trial evaluated 1201 patients with anterior-circulation large-vessel occlusion s…
A secondary analysis suggests higher white blood cell counts may predict better outcomes when adding methylprednisolone to stroke treatment …
Apixaban Reduces Intracranial Bleeding Risk Compared To Aspirin In Patients With Cryptogenic Stroke And Atrial Cardiopathy Evidence
Trial shows apixaban reduces intracranial bleeding risk versus aspirin in cryptogenic stroke patients
In a multicenter randomized trial of 1,015 patients, apixaban demonstrated a significant reduction in intracranial hemorrhage compared to as…
A trial of 1,015 patients found apixaban caused fewer intracranial hemorrhages than aspirin, offering safety insights for those with cryptog…
Endovascular therapy showed no benefit over medical care alone for mild-to-moderate medium or distal vessel occlusion stroke patients in this randomized trial
Endovascular treatment offers no disability benefit for mild-to-moderate stroke patients
A randomized trial involving 543 adults with acute ischaemic stroke found that adding endovascular treatment to standard medical care did no…
A trial of 553 stroke patients found adding endovascular treatment to standard care did not reduce disability compared to medical treatment …
Extended-window alteplase increases functional outcomes but raises hemorrhage risk in acute ischemic stroke patients
Giving clot-busting drugs beyond 4.5 hours raises bleeding risk but may improve function
This meta-analysis of 2,050 adults shows intravenous alteplase beyond 4.5 hours improves functional scores but significantly increases sympt…
A large review of 2,050 stroke patients found higher bleeding risk with late clot-busting drugs, though some functional gains appeared.
Intracranial hemorrhage rates were higher in tenecteplase than standard care at 14.4% versus 9.2% in minor ischemic stroke
Even small bleeds after minor stroke raise death risk in this trial analysis
This secondary analysis of a multicenter randomized controlled trial evaluated 865 patients with minor ischemic stroke within 12 hours of sy…
A look at trial data shows that small bleeds after minor stroke are linked to higher death rates, even if they do not worsen long-term funct…
QSM MRI reveals distinct iron deposition patterns differentiating Parkinsonian syndromes
Brain MRI technique may help tell apart Parkinson's and similar disorders
This systematic review and meta-analysis of 626 PD, 160 MSA, 176 PSP patients and 256 controls found that quantitative susceptibility mappin…
A special MRI can spot distinct brain iron patterns in Parkinson's and related diseases, offering a potential diagnostic tool.
Endovascular thrombectomy boosts functional independence significantly for acute ischemic stroke patients compared to medical management alone
Endovascular thrombectomy offers better recovery chances for stroke patients with large vessel blockages compared to standard medical care alone
A meta-analysis of 718 acute ischemic stroke patients found endovascular thrombectomy significantly improved functional independence versus …
A review of stroke treatments shows that removing the blockage with a catheter leads to much better recovery. This works well for patients w…
Continuous subcutaneous foslevodopa/foscarbidopa improves off time in Parkinson's disease; severe adverse events higher in prior DBS group
Patients with Parkinsons disease who had prior brain surgery saw more side effects while using new skin patches
This post hoc analysis of an open-label phase 3 trial evaluated continuous subcutaneous infusion of foslevodopa/foscarbidopa in 244 patients…
A new look at trial data shows skin patches help Parkinsons patients move better and sleep longer. However, those who had brain surgery earl…
Post hoc analysis shows unsuccessful thrombectomy does not worsen outcomes for large ischemic infarcts compared to medical treatment alone
Unsuccessful clot removal did not worsen outcomes for patients with large strokes
In patients with large ischemic infarcts, unsuccessful endovascular thrombectomy did not increase mortality or worsen functional outcomes ve…
For patients with large strokes, a less successful clot removal did not lead to worse survival or function compared to medical treatment alo…
Systematic review finds inflammatory markers elevated in Alzheimer's disease compared to healthy controls across 41 studies
Inflammatory markers linked to Alzheimer's and other dementia types
This systematic review and meta-analysis examined 41 eligible studies involving healthy controls and patients with various dementia subtypes…
A large review found that people with Alzheimer's and other dementias show higher inflammation than healthy people, though more research is …