Systematic review finds gut microbiome dysbiosis associated with ALS progression
Could gut bacteria changes be linked to ALS, or just happen alongside it?
This systematic review with narrative synthesis examined 61 studies on gut microbiome alterations in ALS.
People with ALS often show reduced gut bacteria diversity, but it is still unclear if these changes cause the disease or simply happen along…
Mini-review synthesizes dementia risk and cognitive trajectories in individuals with schizophrenia
Do people with schizophrenia face a higher risk of dementia, and what does that mean for their care?
This mini-review examines the relationship between schizophrenia and dementia, covering Alzheimer's disease, vascular dementia, and other fo…
People with schizophrenia face a two- to threefold higher risk of dementia, but it's not a direct path to Alzheimer's—brain development, agi…
Mobile respiratory training improved lung function in acute stroke patients with respiratory dysfunction
Mobile respiratory training improved lung function in hospitalized stroke patients with breathing issues
This single-center randomized controlled trial enrolled 40 inpatients with acute stroke and respiratory dysfunction.
A mobile breathing app helped hospitalized stroke patients improve lung capacity by 0.77 liters compared to standard care alone.
Cerebral infarction common in tuberculous meningitis and linked to disease severity and arterial occlusion
Could blood thinners or specific treatments make brain strokes worse in severe meningitis?
This secondary analysis of the ACT-TBM randomized trial examined 226 patients with tuberculous meningitis at two tertiary centers in India.
Patients with tuberculous meningitis and blocked arteries were much more likely to develop strokes, especially if they received modified tub…
Plasma biomarker models show high discrimination but NPV decline in cross-cohort Alzheimer's validation
Can a blood test predict Alzheimer's in new patients? The answer depends on where the test was developed
A cohort study in ADNI and A4 cohorts (n=885 and n=822) found that machine learning models using plasma biomarkers achieved ROC AUCs of 0.91…
A promising Alzheimer's blood test loses its accuracy when used on a different patient group, raising concerns about false reassurance in re…
Review synthesizes electroacupuncture effects on cerebral ischemia-reperfusion injury mechanisms
Could electroacupuncture protect the brain from injury, and what does the current review tell us?
This narrative review examines the role of electroacupuncture in addressing cerebral ischemia-reperfusion injury.
Electroacupuncture may shield the brain from stroke-related damage by reducing inflammation and protecting cells, though real-world safety a…
Systematic review examines yoga effects on brain structure and function in healthy participants across 23 studies
Could yoga change your brain, and what does the latest research actually tell us?
This systematic review synthesizes findings from 23 international peer-reviewed neuroimaging studies involving healthy participants to asses…
Yoga may change your brain's structure and function, but mixed study results mean we don't know exactly which parts of the practice help yet…
Single-center Phase 1 RCT assesses ALC05 injection safety in unilateral mesial temporal lobe epilepsy patients
New Cell Therapy Could Stop Seizures Safely
This single-center Phase 1 randomized controlled trial evaluated the safety of a single intracranial injection of ALC05, iPSC-derived GABAer…
A new cell therapy aims to stop seizures safely by injecting living cells into the brain, offering a gentler alternative to risky surgery fo…
Review explores PARP-1 and α-synuclein interactions in Parkinson's disease neuropathology
Could a protein switch drive the nerve damage seen in Parkinson's disease?
This narrative review synthesizes evidence on the interplay between PARP-1 activation and α-synuclein in Parkinson's disease, highlighting r…
An overactive protein switch in brain cells triggers the clumps and stress that drive nerve damage in Parkinson's disease.
qMPM metrics show microstructural alterations in white matter hyperintensities and perilesional tissue
New brain scan metrics show subtle changes in white matter linked to cognitive performance in older adults
A cohort study of 245 participants from the BeLOVE study found that quantitative Multi-Parametric Mapping (qMPM) metrics detected significan…
New brain scan metrics detect subtle white matter changes linked to cognitive performance in older adults, offering early insight into brain…
Systemic inflammatory indices are elevated in pediatric drug-resistant epilepsy versus self-limited epilepsy with centrotemporal spikes
Are inflammation markers higher in children with hard-to-treat epilepsy than those with self-limited cases?
This real-world cohort study of 140 pediatric patients compared systemic inflammatory indices (NLR, SII, CRP) between those with drug-resist…
Children with hard-to-treat epilepsy show higher blood inflammation markers than those with self-limited cases, though the exact link to bra…
COVID-19 and vitamin D status linked to IL-6 and IL-18 levels in children
Low Vitamin D Linked to Higher Inflammation in Kids
This cohort study of 170 children aged 1–17 years with PCR-confirmed SARS-CoV-2 infection measured serum IL-6 and IL-18 in relation to vitam…
Low vitamin D might make inflammation worse in children with COVID-19, but doctors need more proof before changing treatment plans.