Noninvasive brain stimulation reduces pain intensity in central poststroke pain with a pooled effect size of -0.64
Noninvasive brain stimulation reduces pain in stroke survivors but does not fix mood
This systematic review and meta-analysis evaluated noninvasive brain stimulation versus sham stimulation in patients with central poststroke…
A review of 430 patients found noninvasive brain stimulation lowers pain in central poststroke pain, though it does not improve mood or qual…
Interactive cognitive-motor training improves mobility, gait, and balance in chronic stroke
Interactive training boosts balance and movement for people with chronic stroke
This systematic review and meta-analysis of 1422 people with chronic stroke found that interactive cognitive-motor training significantly im…
A large review found interactive cognitive-motor training significantly improved balance, mobility, and gait speed for people with chronic s…
GBA1 L444P carriers have ninefold higher odds of Parkinson's disease than non-carriers
People with one GBA1 L444P gene change face much higher risk of developing Parkinson's disease compared to those without it
This systematic review and meta-analysis of 33,752 PD patients and 34,101 controls found that heterozygous GBA1 L444P carriers had markedly …
A large review of over sixty-seven thousand people found that carrying one copy of the GBA1 L444P gene change greatly increases the chance o…
Integrative brain care bundles and transdisciplinary training dismantle structural barriers in maternal-child health globally
New training bundles aim to fix fragmented brain care for mothers and babies worldwide
This narrative review examines global healthcare systems and diverse clinical settings regarding transdisciplinary fetal-neonatal neurology …
Experts suggest new training and care bundles could help integrate brain health support for mothers and infants across the globe.
Oral Semaglutide Failed to Slow Clinical Progression in Early Alzheimer's Disease Across Global Phase 3 Trials
Oral semaglutide did not slow Alzheimer's disease progression in early trials
In large phase 3 trials, oral semaglutide showed no benefit over placebo for patients with early Alzheimer's disease. The drug did not impro…
A large trial found that taking oral semaglutide offered no benefit over placebo for people with early Alzheimer's disease.
High-dose ocrelizumab 1200/1800 mg shows no significant difference in disability progression versus 600 mg in MS
High-dose ocrelizumab did not further reduce disability progression in multiple sclerosis patients
This phase 3b randomized controlled trial in 860 and 753 patients with relapsing or primary progressive multiple sclerosis found that high-d…
A large trial found that higher doses of ocrelizumab did not lower the risk of disability progression compared to the standard dose in multi…
Ocrelizumab reduces disability progression risk in primary progressive multiple sclerosis versus placebo
Ocrelizumab reduces disability risk for primary progressive multiple sclerosis patients
This phase 3b trial evaluated intravenous ocrelizumab versus placebo in patients with primary progressive multiple sclerosis. The study foun…
A large trial found ocrelizumab significantly lowers the risk of disability progression in patients with primary progressive multiple sclero…
Prasinezumab showed non-significant delay in motor progression versus placebo in early-stage Parkinson's disease
Early Parkinson's drug trial shows no delay in motor progression
This phase 2b trial evaluated intravenous prasinezumab in individuals with early-stage Parkinson's disease on stable medication. The study f…
A Phase 2b trial of prasinezumab in early Parkinson's disease failed to meet its primary endpoint of delaying motor progression compared to …
Robot-assisted gait training improves walking ability and functional independence in spinal cord injury
Robot training improves walking after spinal cord injury
This systematic review and meta-analysis of 241 participants with spinal cord injury found that robot-assisted gait training led to signific…
Robot-assisted gait training helps people with spinal cord injury walk farther and more independently than standard rehab alone.
T cell-microglial interactions drive aging and myelin changes in neurodegeneration models
Aging changes brain cells and invites immune cells that hurt nerve repair
This narrative review synthesizes evidence from murine models on T cell-microglial interactions in aging and neurodegeneration. It argues th…
Aging alters brain cell signals and brings in immune cells that damage myelin and stop nerve repair in mouse models.
Sleep and circadian rhythm alterations associate with prolonged ventilation and worse outcomes in adult ICU patients
Disrupted sleep in the ICU linked to worse outcomes
This narrative review examines sleep and circadian rhythm alterations in adult ICU patients. The authors synthesize associations between dis…
Poor sleep in the ICU is tied to longer ventilation, delirium, and lasting health problems. New review highlights the hidden cost of broken …
Network meta-analysis compares alteplase, tenecteplase, and JX10 for acute ischemic stroke treatment outcomes
New analysis compares three clot-busting drugs for stroke patients treated up to twenty-four hours after symptoms start
This network meta-analysis evaluated intravenous thrombolytic agents for acute ischemic stroke. Alteplase significantly improved functional …
A large review found one standard drug helped more patients walk again than usual care, while a new drug showed promise but needs more testi…