Modeling suggests 30% Parkinson's progression reduction may lower 10-year milestone risks
Study models how slowing Parkinson's progression might reduce long-term risks
An observational cohort study of Parkinson's disease patients from the Oxford Parkinson's Disease Centre modeled a hypothetical 30% reductio…
Slowing Parkinson's disease progression by 30% could reduce long-term risks like dementia, falls, and death by up to 7.5% over 10 years, acc…
Carotid PWV and TyG index may help discriminate LAA from SVO in acute ischemic stroke
Could a simple test help doctors quickly identify the type of stroke?
A single-center retrospective cohort study of 298 acute ischemic stroke patients found large-artery atherosclerosis (LAA) patients had highe…
Doctors might soon spot the cause of a stroke faster by checking neck artery stiffness and blood sugar levels.
Preoperative CSF metabolic profiles associated with recovery potential after shunt placement for NPH
Can fluid chemistry before surgery predict who will walk and think better after shunt placement?
A cohort study of patients undergoing shunt placement for normal pressure hydrocephalus found preoperative cerebrospinal fluid metabolite pr…
Spinal fluid chemistry before shunt surgery can predict which patients will see better walking and thinking results after the procedure.
Greater cognitive variability in NSD Stage 2 predicts progression to advanced stages in observational study
Could a simple test of mental consistency help spot early Parkinson's disease?
An observational study of 934 participants from the Parkinson's Progression Markers Initiative found that greater intraindividual cognitive …
A simple mental consistency test can spot early Parkinson's disease signs before obvious symptoms appear, helping predict who will progress …
Resting-state fMRI shows reduced brain entropy in episodic and chronic migraine compared to healthy controls
Brain entropy changes in migraine patients compared to healthy controls
This resting-state fMRI study examined brain entropy in adults with episodic migraine, chronic migraine, and healthy controls.
Migraine patients show lower brain complexity in key networks compared to healthy controls, with the biggest drop seen in chronic cases.
Lp-PLA2 activity does not significantly modify dual antiplatelet therapy efficacy in minor stroke/TIA with CYP2C19 loss-of-function alleles
Blood enzyme levels don't change which stroke prevention drug works better, study finds
This subgroup analysis of the CHANCE-2 RCT examined 5919 patients with minor stroke/TIA and CYP2C19 loss-of-function alleles.
A simple blood test for inflammation doesn't predict which stroke prevention drug works best for patients with a specific genetic trait.
Meta-analysis finds nonlinear dose-response between physical activity and reduced stroke risk
How much exercise protects against stroke? A new analysis finds the sweet spot
A meta-analysis of 14 prospective cohort studies with 2.6 million participants found nonlinear inverse associations between physical activit…
A new analysis of over 2.6 million people finds that moderate exercise—like a few vigorous workouts weekly—can cut stroke risk by up to 19%,…
PTPN1 variants identified in 17% of AGS cohort with later onset and reduced penetrance
Could a common gene variant explain some cases of a rare childhood brain disease?
A genomic cohort study identified ultra-rare heterozygous PTPN1 variants in 9 of 53 individuals with suspected Aicardi-Goutières syndrome (A…
A common gene variant linked to autoimmune conditions may explain some cases of a rare childhood brain disease that starts later than usual.
High-dose thiamine use increased for Wernicke encephalopathy in Japan; functional impairment common at discharge
Did more high-dose vitamin B1 help patients with alcohol-related brain damage?
A 13-year observational study of 7,856 hospitalized Wernicke encephalopathy patients in Japan found initial high-dose thiamine use increased…
Despite a surge in high-dose vitamin B1 use for alcohol-related brain damage, over half of patients still leave the hospital unable to care …
Case series finds brain morphology alterations in 11 patients with NGLY1 Deficiency
Brain scans show structural differences in patients with rare NGLY1 Deficiency
A case series of 11 patients with NGLY1 Deficiency analyzed 16 real-world MRI scans against normative models.
Researchers analyzed brain scans from 11 patients with the ultra-rare genetic disorder NGLY1 Deficiency.
NODDI MRI shows phenotype-specific white matter alterations in Wilson disease patients
What does Wilson disease do to the brain's wiring? A new scan shows specific damage
An observational study of 30 Wilson disease patients and 30 matched controls found phenotype-specific microstructural white matter alteratio…
A new brain scan reveals specific wiring damage in Wilson disease patients, linking reduced nerve fiber density directly to slower processin…
Spinal cord injury linked to altered cortical excitability response to repeated tDCS
Could a brain's 'reset button' work differently after spinal cord injury?
A crossover study in 20 adults with thoracic or below spinal cord injury and 20 healthy controls found greater corticomotor excitability fac…
After spinal cord injury, the brain's 'reset button' may weaken, leading to greater excitability and potentially explaining persistent sympt…