Cognitive training perspectives show no significant far transfer effects in acute stroke rehabilitation trial
Can changing how stroke patients think about space help their mood and movement?
A randomized clinical trial of 128 acute stroke patients found that adding allocentric or egocentric perspective cognitive training to conve…
Adding mental exercises to stroke rehab did not improve mood or movement compared to standard care alone in a study of 128 patients.
High-dose melatonin linked to hepatotoxicity in small PP-MS trial, prompting early halt
High-dose melatonin trial halted after liver safety concerns in MS patients
A phase I/II RCT of 8 patients with PP-MS on stable ocrelizumab found that adjunctive high-dose oral melatonin (300 mg/day) was associated w…
A high-dose melatonin trial for multiple sclerosis stopped early after three of four patients developed mild liver injury, though the issue …
Methodological analysis questions predictive value of plasma p-tau217 disease clocks for Alzheimer's onset
Study questions how well a blood test predicts Alzheimer's disease symptom timing
A methodological analysis of ADNI data from individuals who progressed to symptomatic Alzheimer's disease found that baseline age alone expl…
A new analysis suggests Alzheimer's blood test models may overstate their accuracy because they rely mostly on age rather than actual biomar…
Meta-analysis finds depression associated with elevated Parkinson's disease risk
Could depression be an early sign of Parkinson's disease?
A meta-analysis of observational studies found depression was associated with approximately double the risk of developing Parkinson's diseas…
People with depression are about twice as likely to develop Parkinson's disease later, and brain scans in late-onset depression often show e…
Systematic review suggests omega-3 deficiency may be modifiable risk factor for mental disorders
Review finds omega-3 fatty acid levels may be linked to brain health disorders
A systematic review of evidence across mental, neurodevelopmental, and neurodegenerative disorders suggests omega-3 deficiency and altered f…
Low omega-3 levels may act as a changeable risk factor for brain disorders like schizophrenia, ADHD, and Alzheimer's, offering a potential t…
Explainable AI methods may address black-box limitations in clinical microbiology and infectious diseases
Review explores how explainable AI could help in infectious disease medicine
A narrative review examines Explainable AI (XAI) methods in clinical microbiology, infectious diseases, and public health.
Explainable AI tools could help doctors trust computer decisions in fighting infectious diseases, but current systems remain too opaque for …
Review suggests acupuncture may target cell death pathways in Parkinson's disease
Could acupuncture protect brain cells in Parkinson's disease?
A systematic review examined the role of programmed cell death in Parkinson's disease pathogenesis and the potential of acupuncture to targe…
Acupuncture may protect brain cells in Parkinson's disease by calming the inflammation and stress that trigger the cell death driving the co…
Protocol for argatroban plus clopidogrel versus aspirin plus clopidogrel in acute minor ischemic stroke
Study will compare two blood thinner combinations for minor strokes
This is a study protocol for a randomized controlled trial of 464 patients with acute minor ischemic stroke (NIHSS ≤5) within 72 hours.
A new trial will test if adding argatroban to clopidogrel leads to better recovery than aspirin plus clopidogrel for minor stroke patients.
CSF proteomic signatures show potential for MS diagnosis and prognosis in cohort study
Could a spinal fluid test predict how multiple sclerosis will progress?
A multicentric cohort study of 120 patients with multiple sclerosis, clinically isolated syndrome, and healthy controls analyzed cerebrospin…
A spinal fluid test with ten proteins could predict multiple sclerosis progression, showing promise for forecasting disease activity up to f…
DBSgram framework demonstrates feasibility for biomarker-guided DBS programming in Parkinson's disease
Can brain signals and motion sensors help fine-tune Parkinson's treatment?
A cohort study of 18 Parkinson's disease patients with sensing-enabled DBS systems demonstrated technical feasibility of the DBSgram framewo…
A new system combines brain signals and wearable sensors to create visual guides that help doctors fine-tune Parkinson's deep brain stimulat…
Retrospective study finds variation in COPD exacerbation care between respiratory and internal medicine
Does your hospital specialty affect your COPD care? A new study finds variation
A retrospective cohort study of 6,277 adults hospitalized for COPD exacerbations found variation in investigations and treatment practices b…
Hospital specialty matters for COPD care, as a new study shows different treatments for patients admitted to respiratory medicine versus int…
Higher remnant cholesterol and CHG index associated with lower hemorrhagic transformation risk after IV thrombolysis
Could cholesterol and blood sugar levels predict stroke treatment risks?
A dual-center retrospective cohort study of 4403 acute ischemic stroke patients undergoing IV thrombolysis found that higher levels of remna…
Higher cholesterol and blood sugar levels may signal lower risk of dangerous bleeding after stroke clot-busting treatment, offering a new wa…