Tirzepatide maximum tolerated dose leads weight reduction ranking in obesity network meta-analysis
New analysis shows weight loss drugs work best for adults with obesity without diabetes
This systematic review and network meta-analysis of 14,059 adults with obesity without diabetes ranked GLP-1 receptor agonists and a dual ag…
A large review of many studies found that specific injectable medicines help adults lose weight. Tirzepatide worked best, but all options re…
Insulin degludec/liraglutide ranks highest for HbA1c reduction with SUCRA value of 89.4%
Comparing Combination Diabetes Drugs for Blood Sugar Control
This network meta-analysis evaluated 12,815 patients with type 2 diabetes to compare fixed-ratio combination products and their individual c…
A review of 12,815 patients found that insulin degludec/liraglutide may be best for lowering blood sugar, but has more side effects than oth…
Modulating endogenous PYY expression offers a theoretical basis for individualized obesity management strategies
Ways to boost body's fullness hormone for weight control
This narrative review discusses modulating endogenous PYY expression via dietary interventions, bariatric surgery, exercise therapy, and phy…
This review explores how diet, surgery, and exercise can raise PYY levels, helping people feel fuller and manage weight more effectively.
Vitamin D improves strength and reduces injuries in dancers, while iron lowers anemia prevalence
Dancers take many supplements, but benefits are often unproven and risks remain unclear
This systematic review of dietary supplement and medication use in 654 female and 86 male professional and pre-professional dancers found vi…
Dancers use many supplements and painkillers, yet benefits are limited and potential health risks need more study before we can trust them.
Commercial preterm formulas with glucose polymers and reduced lactose show higher necrotizing enterocolitis rates than breast milk
Commercial preterm formulas carry higher NEC risk than breast milk
This comprehensive review examines the association between commercial preterm formulas and necrotizing enterocolitis in preterm infants. The…
A review finds commercial preterm formulas with glucose polymers and reduced lactose are linked to higher rates of necrotizing enterocolitis…
Metabolic and bariatric surgery significantly reduces plasma Fetuin-A levels in patients with obesity
Metabolic surgery lowers a blood protein linked to obesity and high sugar
This systematic review and meta-analysis examines plasma Fetuin-A expression and metabolic changes in patients with obesity undergoing metab…
Metabolic surgery significantly reduced a blood protein called Fetuin-A while also lowering BMI and blood sugar in patients with obesity.
Nutrient and metabolite interventions for neurodegenerative diseases show inconsistent clinical translation
Dietary nutrients show mixed results for brain diseases in lab and early human data
This narrative review synthesizes evidence on nutrients and metabolites for Alzheimer's, Parkinson's, multiple sclerosis, and amyotrophic la…
Nutrients like vitamins and marine compounds show promise in labs, but human evidence for brain diseases remains inconsistent and unclear.
Eating later in the biological day is associated with impaired glucose regulation and reduced insulin sensitivity
Eating later in the day is linked to worse blood sugar and heart health markers
This narrative review examines chrononutrition in obesity, type 2 diabetes, hypertension, and cardiovascular disease. Findings indicate that…
A review suggests eating later in the biological day is associated with impaired glucose regulation and reduced insulin sensitivity in peopl…
Cultured meat production requires integrated cell selection and regulatory compliance for complex tissue replication
Making Cultured Meat Needs Many Different Cell Types Working Together To Succeed
This critical comparative review examines cultured meat production using various cell types. It finds that no single cell type can fully rep…
Building real meat in a lab is hard work. Scientists found that no single cell type can do it alone. You need specific cells for structure, …
GLP-1 agonists show short-term metabolic benefit in PCOS but reproductive effects remain uncertain
Doctors suggest GLP-1 drugs help weight but need careful planning before pregnancy in PCOS
A meta-analysis of GLP-1 receptor agonists in PCOS found relatively robust support for short-term metabolic benefit, but reproductive outcom…
New analysis shows GLP-1 drugs help with weight loss for PCOS patients. However, doctors are unsure if these drugs improve fertility and nee…
Sitagliptin and liraglutide superior for CGM targets in type 2 diabetes
Two diabetes drugs outperform others in long-term glucose control
This randomized trial compared adding sitagliptin, liraglutide, glimepiride, or insulin glargine to metformin in 1,080 participants with typ…
A five-year trial shows sitagliptin and liraglutide offer better glucose stability and safety than glimepiride or insulin glargine for peopl…
Bariatric surgery yields greater long-term weight loss than GLP-1 receptor agonists in adults with obesity
Bariatric surgery leads to more weight loss than GLP-1 drugs over one year
This meta-analysis compared bariatric surgery against GLP-1 receptor agonists in adults with obesity. While weight loss differences were not…
A large analysis of 20,594 adults found bariatric surgery caused greater weight loss than GLP-1 drugs after one year, with benefits growing …