No established correlation exists between paragangliomas and cervical lymph node metastasis in papillary thyroid carcinoma
Distinguishing Between Thyroid Cancer and Paraganglioma for Better Diagnosis
This case report and literature review examines the relationship between paragangliomas and cervical lymph node metastasis in patients with …
Doctors must accurately distinguish between thyroid cancer and paragangliomas to ensure correct treatment plans and accurate patient prognos…
Local therapy and intrathecal chemotherapy may manage CNS progression in EGFR-mutant NSCLC patients
Combined Treatments May Help Manage Brain Metastases in Lung Cancer
This case report and literature review describes a patient with EGFR-mutant NSCLC and brain/leptomeningeal metastases. The authors suggest t…
A new treatment approach combining surgery, local chemotherapy, and targeted drugs may help manage brain cancer spread for some patients.
Metabolic reprogramming and plasticity drive tumor progression and resistance through interconnected transcription factors and enzymes
Metabolic Plasticity Drives Cancer Growth and Resistance
This narrative review examines how metabolic reprogramming, driven by transcription factors like MYC and HIF-1α, facilitates cancer progress…
Cancer cells rewire their metabolism to fuel growth and resist treatment. A new review maps the complex network behind this process.
Sinonasal NUT carcinoma with leptomeningeal carcinomatosis may require early multimodal treatment and surgical intervention
New case shows how certain nasal cancers spread to brain lining
This case report and review describes a 32-year-old woman with sinonasal NUT carcinoma who developed leptomeningeal carcinomatosis. The auth…
A rare nose and sinus cancer can spread quickly to the brain's lining, making early diagnosis and surgery vital for patient survival.
Alectinib improves progression-free survival over crizotinib in ALK-positive NSCLC (HR 0.41)
Alectinib Shows Better Progression-Free Survival Than Crizotinib for NSCLC
This pooled analysis of Phase III trials involving 500 patients with ALK-positive NSCLC found that alectinib significantly improved progress…
Alectinib showed better progression-free survival than crizotinib in a study of 500 patients with ALK-positive lung cancer.
Lenvatinib plus pembrolizumab did not improve overall survival compared to standard of care
Trial shows lenvatinib and pembrolizumab do not improve survival
This Phase 2 randomized trial evaluated lenvatinib and pembrolizumab in 374 adults with recurrent or metastatic head and neck squamous cell …
A Phase 2 trial found that a combination of lenvatinib and pembrolizumab did not improve overall survival for patients with advanced head an…
LAMS and BFMS show higher clinical success rates than DPPS for pancreatic fluid collections
New data reveals better stent options for pancreatic fluid collections
This network meta-analysis of 38 studies included 4265 patients with pancreatic fluid collections (PFCs) to compare various drainage methods…
Different types of stents offer varying success rates and safety profiles for patients with complex drainage needs after pancreatic issues.
Circulating microRNAs and lipidomic/metabolomic biomarkers show 0.92 SROC AUC for early breast cancer detection
Blood markers show promise for early breast cancer detection
This meta-analysis of 6,935 participants evaluated the diagnostic accuracy of circulating microRNAs and lipidomic/metabolomic biomarkers in …
A new analysis of 35 studies finds that blood-based biomarkers can detect early breast cancer with high accuracy, but more research is neede…
Transsphenoidal surgery achieves 73.88% remission rate in Cushing's Disease
Factors linked to higher remission rates in Cushing's Disease surgery
A meta-analysis of 11,666 patients with Cushing's Disease found that transsphenoidal surgery yields an overall remission rate of 73.88%. Hig…
New data identifies specific surgical and imaging factors that may help doctors predict better outcomes for patients undergoing surgery for …
Daraxonrasib improves overall survival to 13.2 months in mPDAC patients compared to 6.7 months
Trial shows daraxonrasib improves survival for pancreatic cancer patients
This Phase 3 randomized trial of 500 patients with previously treated metastatic pancreatic ductal adenocarcinoma found daraxonrasib signifi…
A Phase 3 trial found that daraxonrasib significantly extended survival times for patients with specific types of metastatic pancreatic canc…
Minimally invasive pancreaticoduodenectomy reduces blood loss and hospital stay in distal cholangiocarcinoma surgery
Minimally invasive surgery shows benefits for certain bile duct cancer
This meta-analysis of retrospective cohort studies evaluates minimally invasive pancreaticoduodenectomy (MIPD) compared to open pancreaticod…
Minimally invasive surgery can reduce blood loss and hospital stays for patients undergoing surgery for distal cholangiocarcinoma.
5-ALA fluorescence-guided surgery improves gross total resection rates in patients with glioblastoma
Fluorescence guided surgery improves tumor removal for glioblastoma patients
This meta-analysis of 790 patients found that 5-ALA guided surgery significantly improved gross total resection (RR = 1.54, 95% CI: 1.16-2.0…
A special light guide helps surgeons remove more of a brain tumor while keeping patient safety and recovery rates steady.