ctDNA positivity linked to increased risk of brain metastases in advanced solid tumors
ctDNA in blood and spinal fluid predicts brain metastases risk
This systematic review and meta-analysis of 1763 patients with advanced solid tumors found that ctDNA positivity is associated with a signif…
A new analysis finds that tumor DNA in blood or spinal fluid can signal a higher risk of brain metastases and worse survival.
Meta-analysis shows sublobar resection linked to worse survival outcomes compared with lobectomy for early-stage non-small cell lung cancer patients
Sublobar resection shows mixed survival results for early lung cancer
This umbrella review of meta-analyses indicates sublobar resection carries higher risks for overall and disease-free survival in Stage I non…
An umbrella review found mixed survival results for sublobar resection versus lobectomy in early-stage non-small cell lung cancer.
Vascular smooth muscle cell immune interactions drive remodeling across cardiovascular diseases
How blood vessel cells drive heart disease and high blood pressure
This narrative review synthesizes mechanisms of VSMC-immune interactions in atherosclerosis, hypertension, aortic aneurysms, and arteritis. …
A new review reveals how blood vessel cells change in heart disease, high blood pressure, and more.
26 Gy in 5 fractions non-inferior to 40 Gy in 15 fractions for breast cancer recurrence at 10 years
Shorter radiation treatment works just as well for breast cancer patients after surgery
This phase 3 randomised trial compared two hypofractionated radiotherapy schedules (26 Gy and 27 Gy in 5 fractions) with standard 40 Gy in 1…
Doctors found that giving five days of lower-dose radiation is safe and effective. This option helps patients recover faster without increas…
E-health self-management interventions improve quality of life in cancer patients with a standardized mean difference of 0.18
Digital self-help tools improved quality of life for cancer patients in a review of thirty trials
This meta-analysis of randomized controlled trials evaluated self-management interventions based on e-health for patients with cancer. Thirt…
A review of thirty trials shows digital self-help tools significantly improved quality of life for cancer patients, though more research is …
Large energy acceptance beam delivery systems may enable ultra-fast treatment within 10 seconds compared to conventional systems
Review shows Large energy acceptance beams may speed up cancer treatment delivery
This review examines opportunities and design concepts for large energy acceptance (LEA) beam delivery systems. It contrasts these with conv…
A review suggests Large energy acceptance beam systems could cut treatment times and improve motion management for cancer patients.
Screening and management strategies for stigma in patients with colorectal cancer and stomas require clinically meaningful guidance
Guidance helps manage stigma for colorectal cancer patients with stomas
This best evidence summary review addresses screening and management strategies for stigma in patients with colorectal cancer and stomas. Th…
This review offers practical advice for screening and managing stigma in patients with colorectal cancer and stomas, aiming to improve their…
Diagnostic prediction models show moderate-to-good discrimination for cancer-related fatigue
Prediction models show moderate accuracy for cancer-related fatigue
This systematic review and meta-analysis of 13 studies involving 444,447 cancer patients found that diagnostic prediction models for cancer-…
A large analysis of 13 studies found prediction models can moderately identify cancer-related fatigue in over 444,000 patients, though resul…
Intrathecal chemotherapy via Ommaya reservoir improves survival in leptomeningeal metastasis
Ommaya reservoirs may help patients with leptomeningeal metastasis live longer than lumbar punctures
This systematic review and meta-analysis of four comparative studies found that intrathecal chemotherapy via Ommaya reservoir was associated…
A new analysis suggests Ommaya reservoirs improve survival and lower side effects for patients with leptomeningeal metastasis compared to lu…
Low pretreatment lymphocyte-to-monocyte ratio linked to worse survival in cervical cancer
Low LMR Linked to Worse Survival in Cervical Cancer Patients
This systematic review and meta-analysis of 5,127 patients found that low pretreatment lymphocyte-to-monocyte ratio (LMR) is associated with…
A low lymphocyte-to-monocyte ratio before treatment predicts poorer survival outcomes for patients with cervical cancer, suggesting a potent…
Lower baseline quality of life linked to 7% higher mortality risk in lung cancer patients
Low quality of life before treatment links to higher death risk in lung cancer patients
This systematic review and meta-analysis of 20,235 lung cancer patients across 18 countries found that lower pre-treatment global quality of…
A large study of 20,235 lung cancer patients found that lower quality of life before treatment was linked to higher mortality risk.
Angiogenesis inhibitors combined with chemotherapy improve progression-free survival in advanced breast cancer patients
Adding angiogenesis inhibitors to chemotherapy helps advanced breast cancer patients stay disease-free longer
This systematic review and meta-analysis of phase II and III trials evaluated angiogenesis inhibitors combined with chemotherapy versus chem…
A large review of eight thousand four hundred patients found that adding angiogenesis inhibitors to standard chemotherapy improved how long …