Ovarian function recovery in premenopausal women after chemotherapy remains modest despite improvement over 60 months
Chemotherapy Impacts Ovarian Function Recovery in Premenopausal Breast Cancer Patients
This meta-analysis of 10,216 patients evaluates the probability and predictors of ovarian function recovery following chemotherapy in premen…
New data shows that while ovarian function can improve after chemotherapy, the recovery rates remain modest for premenopausal women with bre…
Ileal neobladder provides superior nighttime continence and fewer early complications compared to sigmoid neobladder
Ileal neobladder shows better nighttime continence for bladder cancer patients
This meta-analysis of 17 studies involving patients undergoing radical cystectomy for neobladder reconstruction compares ileal and colonic n…
Patients with bladder cancer may experience fewer early complications and better nighttime continence with an ileal neobladder compared to a…
AENK-T cell fate is determined by specific receptor emergence and transcriptomic axes during exhaustion
Immune Cells Face Exhaustion Challenges in Cancer Treatment
This narrative review synthesizes transcriptomic, epigenomic, and functional data regarding the trajectory of antigen-experienced NK-T (AENK…
New research maps how specific immune cells change during cancer treatment, moving from active fighters to exhausted states in certain envir…
Polygenic methylation patterns are linked to osimertinib resistance in non-small cell lung cancer
Methylation Patterns Linked to Drug Resistance in Lung Cancer
This systematic review examines the role of polygenic DNA and RNA methylation in osimertinib resistance for patients with non-small cell lun…
New research identifies how changes in DNA and RNA methylation may contribute to drug resistance in patients with non-small cell lung cancer…
Psychosocial Interventions Improve Neurocognitive, Psychological, and Quality-of-Life Outcomes in Children With Cancer
Psychosocial Interventions Improve Quality of Life for Children with Cancer
This meta-analysis of 34 studies (1988 children and adolescents aged 0 to 19 years with cancer) found significant positive effects of psycho…
Psychosocial programs like play therapy and animal assistance show promise in improving mental health and cognitive outcomes for children wi…
High-throughput omics approaches identify biomarkers for myocarditis, pneumonitis, and colitis in ICI patients
Mapping biomarkers to track side effects from cancer treatments
This scoping review of 86 studies maps omics-based biomarkers for immune-related adverse events (irAEs) including myocarditis, pneumonitis, …
New research maps complex biological data to help identify and monitor serious side effects caused by immune checkpoint inhibitors.
DOACs prescribed in 89.6% of cases following treatment discontinuation in cancer-associated thrombosis
Doctors face inconsistent choices when treating cancer and blood clots
This descriptive analysis of 1458 patients with cancer and venous thromboembolism examined investigator decisions after blinded treatment di…
New data shows that doctors often make inconsistent decisions about blood thinner dosages for cancer patients, highlighting a gap in standar…
Sintilimab Combined With Chemotherapy Improves Outcomes in Advanced Gastroesophageal Cancer
Immunotherapy combined with chemotherapy improves survival for gastroesophageal cancer
A meta-analysis of 6,625 patients shows that adding PD-1 inhibitors to chemotherapy significantly improves survival in advanced gastroesopha…
Combining immunotherapy with chemotherapy offers better survival outcomes for patients with advanced gastroesophageal cancer than chemothera…
Exergaming shows favorable outcomes for mobility, balance, and fatigue in adults with cancer
Interactive video games can help adults with cancer improve mobility
This systematic review of 19 distinct study cohorts indicates that exergaming provides favorable findings for mobility, balance, and quality…
Interactive digital games that require movement can help cancer patients improve their balance, strength, and overall quality of life.
Percutaneous microwave ablation under ultrasound guidance achieves 86.0% clinical cure rate at 6 months
Microwave Ablation Shows Promise for Treating Primary Hyperparathyroidism
This meta-analysis of 355 patients with primary hyperparathyroidism found that percutaneous microwave ablation under multiparametric ultraso…
A new minimally invasive microwave treatment shows high success rates in treating primary hyperparathyroidism while lowering calcium and hor…
Adaptive Phase I/II designs for drug combinations remain methodologically diverse but rarely implemented
New trial designs could speed up testing drug combinations
This narrative review surveys adaptive Phase I/II clinical trial designs for drug combinations, covering model-based, model-assisted, utilit…
New trial designs could help researchers test combinations of drugs for cancer more quickly and efficiently.
HER2-positive invasive ductal carcinoma was identified in a patient with Neurofibromatosis type 1
Case Report Shows Trastuzumab Treatment for Breast Cancer in NF1
This case report describes a 48-year-old woman with Neurofibromatosis type 1 (NF1) diagnosed with HER2-positive invasive ductal carcinoma. T…
A new case report highlights how a woman with Neurofibromatosis type 1 successfully managed breast cancer with surgery and targeted therapy.