Soluble CD146 serves as a marker of microvascular stress and promotes tumor invasion
Soluble CD146 May Help Identify Cancer and Heart Stress
This systematic review examines the role of soluble CD146 (sCD146) in malignant solid tumors and cardiovascular diseases. The authors conclu…
A protein called sCD146 may help doctors identify cancer cell behavior and track stress in heart and lung tissues.
Evidence-based guidelines support team-based perioperative glycemic management for patients with hepatocellular carcinoma
New guidance for blood sugar control before liver cancer surgery
This evidence summary synthesizes 14 documents, including guidelines and randomized controlled trials, to provide guidance on perioperative …
A new evidence summary offers 28 best practice items for managing blood sugar in liver cancer patients before, during, and after surgery.
HPV shows strong association with oropharyngeal SCC while other oncogenic viruses show limited evidence
Viruses linked to oral and throat cancers in new review
This systematic review examines the role of various oncogenic viruses in oral and oropharyngeal squamous cell carcinomas. It identifies a co…
A strong link between HPV and throat cancer is confirmed, while other viruses show less clear evidence of causing cancer.
CXCL16/CXCR6 axis exerts bidirectional regulatory influence on neoplasms and inflammatory disorders like asthma
New Biological Pathways May Help Doctors Treat Cancer and Asthma Better
This narrative review examines the CXCL16/CXCR6 axis as a multifaceted regulator in various pathological processes, including neoplasms and …
Scientists are looking at how a specific protein pathway can influence both cancer growth and lung inflammation.
FDA Approves Ogsiveo (nirogacestat) for Progressing Desmoid Tumors
FDA approves Ogsiveo, first drug for rare desmoid tumors
FDA approved Ogsiveo for adult patients with progressing desmoid tumors who require systemic treatment. Approval based on DeFi trial showing…
The FDA approved Ogsiveo (nirogacestat) for adults with progressing desmoid tumors who need systemic treatment. This is the first drug speci…
Internal mammary and medial-supraclavicular irradiation reduces breast cancer mortality without improving overall survival
Trial shows specific radiation reduces breast cancer deaths over 20 years
This trial evaluated internal mammary and medial-supraclavicular irradiation for patients with early stage breast cancer. While the interven…
A long-term study of over 4,000 women found that a specific radiation technique lowered breast cancer deaths but did not change overall surv…
DEB-BACE Shows Higher Short-Term Response in Unresectable Lung Cancer
Drug Eluting Beads May Improve Treatment Success for Certain Lung Cancer Patients
A meta-analysis of 221 patients found that drug-eluting beads bronchial arterial chemoembolization (DEB-BACE) improves short-term tumor resp…
A new review shows that using drug-eluting beads during a specific procedure may help shrink tumors more effectively than standard methods.
First-line immune checkpoint inhibitor therapy improves progression-free survival and overall survival in MSI-H/dMMR mCRC
Immune checkpoint inhibitors improve survival for certain colorectal cancers
This meta-analysis of more than 600 patients with metastatic colorectal cancer (mCRC) involving microsatellite instability-high or mismatch …
New analysis shows immune checkpoint inhibitors offer better survival and fewer side effects than chemotherapy for specific types of metasta…
Robotic-assisted thoracoscopic segmentectomy increases lymph node stations examined and reduces hospital stay duration
Robotic surgery may help lung cancer patients stay in hospital less
This meta-analysis of 19,805 patients with early-stage NSCLC compares robotic-assisted thoracoscopic segmentectomy (RATS) to video-assisted …
A large review suggests robotic-assisted surgery for early-stage lung cancer can lead to more lymph node checks and shorter hospital stays.
Comparative Analysis of Robot Assisted and Laparoscopic Partial Nephrectomy for Renal Tumors
Robot-assisted surgery shows fewer complications for certain kidney tumors
A meta-analysis of 6,202 patients suggests robot-assisted partial nephrectomy offers comparable oncologic outcomes with superior renal prese…
A large review suggests robot-assisted surgery may lead to less blood loss and better kidney function for patients with specific renal tumor…
Forty-seven clinically relevant late-phase programs identify development trajectories for PD-1 and PD-L1 therapies through 2030
47 late-phase programs aim to improve PD-1/PD-L1 cancer therapies
This narrative review analyzes registry-derived clinical trial data to identify future directions for PD-1 and PD-L1 inhibitor therapies. Th…
A new review maps 47 late-phase programs working to overcome limits of PD-1/PD-L1 cancer treatments through 2030.
Retroperitoneal approach in single-port robot-assisted partial nephrectomy may reduce blood loss and hospital stay
Retroperitoneal approach may offer benefits for kidney cancer surgery
This meta-analysis of 384 patients compares transperitoneal and retroperitoneal approaches for single-port robot-assisted partial nephrectom…
A new look at surgical methods suggests the retroperitoneal approach may reduce blood loss and hospital stays for patients with renal cancer…