Sequential paclitaxel-palbociclib showed no difference in ORR versus reverse sequence in ER+/HER2- breast cancer
New Test Predicts Who Needs Chemo in Breast Cancer
This randomized phase II trial evaluated sequential administration of paclitaxel and palbociclib with endocrine therapy in patients with ER+…
Doctors now have a way to spot patients who can skip chemo and go straight to safer hormone treatment.
Splenectomy versus spleen preservation during total gastrectomy for gastric cancer in adults
Should your surgeon remove your spleen during stomach cancer surgery?
This systematic review of randomized controlled trials evaluated adults undergoing total gastrectomy for gastric cancer in Asia and South Am…
Removing the spleen during stomach cancer surgery may be unnecessary and increases infection risks, challenging a long-standing practice.
PARP inhibitors significantly improve progression-free survival in BRCA-mutated ovarian cancer patients
PARP Drugs Help BRCA Ovarian Cancer Patients Live Longer
This meta-analysis of 12 studies evaluated PARP inhibitor–based therapy in patients with BRCA-mutated ovarian cancer.
Women with BRCA-mutated ovarian cancer gain real survival time gains when using PARP inhibitors to delay cancer growth and stay cancer-free …
Retrospective cohort study of 217 surgically treated borderline ovarian tumors in Southern Sweden compares conservative versus complete staging surgery
A Gentler Surgery for Ovarian Tumors May Be Safer Than We Thought
This retrospective, population-based cohort review evaluated 217 patients with borderline ovarian tumors (BOT) in Southern Sweden.
A less invasive surgery for borderline ovarian tumors may be just as safe as the standard approach, offering fewer complications without har…
Multimodal nomogram predicts axillary pathological complete response in node-positive breast cancer patients
Can scans stop unnecessary breast surgery?
This retrospective cohort study evaluated a multimodal nomogram combining ultrasonography, MRI, and clinicopathological features in 600 pati…
A new scan mix predicts if breast cancer is truly gone before surgery, helping doctors avoid unnecessary removal of lymph nodes and lifelong…
Phase 1 trial of off-the-shelf NK cell therapy shows no DLTs or responses in relapsed/refractory AML
A Safer, Ready-to-Use Cell Therapy Takes Aim at Tough Leukemia
A single-arm, open-label, dose-escalation Phase 1 trial enrolled 6 adults with relapsed/refractory AML who received SAR445419, an off-the-sh…
A new, ready-to-use cell therapy proved safe in a first human trial for aggressive leukemia, offering hope for patients who have run out of …
In Appalachian lung cancer patients, definitive chemoradiotherapy was associated with a 59% incidence of cardiovascular adverse events
A Simple Heart Scan Could Predict Your Biggest Risk During Lung Cancer Treatment
This retrospective cohort study evaluated 86 Appalachian patients with lung cancer treated with definitive chemoradiotherapy at a single ins…
For many battling lung cancer, the treatment meant to save them can quietly damage their heart, and a new analysis shows who is most in dang…
Concurrent TP53 and KRAS alterations show inconsistent survival impact across gastrointestinal cancers
Two Bad Genes Mean Different Things
A database analysis of multi-cancer cohorts found that concurrent TP53 and KRAS alterations were associated with significantly shorter overa…
Having two common cancer gene changes usually signals a worse outcome, but in stomach cancer, this same genetic mix actually predicts the lo…
Mitoxantrone liposome plus CMOP shows high response rates in untreated peripheral T-cell lymphoma patients
New Drug Combo Helps Most Patients With Hard-to-Treat Lymphoma
This phase 1b multicenter clinical trial evaluated mitoxantrone hydrochloride liposome combined with cyclophosphamide, vincristine, and pred…
A new drug combo wrapped in fat bubbles helped 89% of patients with hard-to-treat lymphoma shrink tumors without causing deaths.
Phase 1/2 trial shows RT + bevacizumab + olaptesed pegol extends PFS and OS in unmethylated GBM
New Drug Combo Slows Brain Cancer Growth
A Phase 1/2 expansion arm in six patients with newly-diagnosed, unmethylated GBM found that adding bevacizumab to radiotherapy and olaptesed…
Adding a second drug to stop blood vessel growth gives patients with brain cancer more time before the disease returns.
Meta-analysis shows radiomics-based machine learning models predict recurrence risk in non-small cell lung cancer patients
Your Lung Cancer Scan May Already Hold a Hidden Clue About Its Return
This systematic review and meta-analysis evaluated radiomics-based machine learning models for predicting recurrence risk in 7,964 patients …
Artificial intelligence can find hidden patterns in routine lung scans to predict if common lung cancer will return, giving patients a cruci…
MRLN sparing radiotherapy shows non-inferior survival, reduced toxicity in nasopharyngeal carcinoma
New Radiation Plan Saves Swallowing Power
A phase 3 RCT of 568 adults with untreated, non-metastatic nasopharyngeal carcinoma found MRLN sparing radiotherapy was non-inferior to stan…
A new radiation plan for throat cancer lets patients skip a specific area, helping them keep their swallowing strength and eat normally for …