Preclinical review finds piperine inhibits cancer cell growth and enhances chemotherapy
Piperine shows promise in lab cancer studies but needs more clinical research
A systematic review of preclinical studies found piperine inhibits cancer cell proliferation, enhances chemotherapy effectiveness, and impro…
Lab studies show piperine stops cancer cell growth and boosts chemotherapy, but poor solubility and no human trials limit its current use.
![Meta-analysis finds [68Ga]Ga-FAPI PET shows high diagnostic accuracy for gynecologic cancers](/assets/images/defaults/oncology-1.jpg)
Meta-analysis finds [68Ga]Ga-FAPI PET shows high diagnostic accuracy for gynecologic cancers
Could a new scan spot breast and ovarian cancer tumors better than the standard test?
A meta-analysis of 253 females with breast, ovarian, and cervical cancers compared [68Ga]Ga-FAPI PET to [18F]F-FDG PET imaging.
A new scan using a different tracer finds breast, ovarian, and cervical cancer tumors and spread much better than the standard test doctors …
Elevated neutrophil-to-lymphocyte ratio predicts brain metastasis risk in lung cancer patients
Could a simple blood test help find who is most at risk for brain metastasis from lung cancer?
This systematic review and meta-analysis evaluated three immune inflammatory markers in 3,643 participants with lung cancer.
A simple blood test showing high inflammation markers can predict who is most likely to develop brain metastasis from lung cancer.
Intratumoral H101 plus total neoadjuvant therapy yields pathologic complete response in one patient with metachronous locally advanced rectal cancer
Could a virus help save a patient's rectal cancer and their ability to use the bathroom?
This case report describes a 50-year-old patient with metachronous locally advanced rectal cancer treated with intratumoral injection of rec…
A virus combined with standard therapy helped a 50-year-old man clear his rectal cancer while keeping his bowel control intact.
EMILIN-1 shows dual tumor-suppressive and promoting roles in brain tumor biology review
Review explores dual role of EMILIN-1 protein in brain tumor biology
A systematic review of experimental data describes EMILIN-1's complex role in nervous system tumors.
A protein called EMILIN-1 might slow brain tumors in some ways but could also change the immune response to help them grow faster.
AI/ML-based miRNA signatures show diagnostic potential for early breast cancer detection
Could a simple blood test help find early breast cancer with high accuracy?
A meta-analysis of 7 studies in patients with early breast cancer found AI/ML-based circulating miRNA signatures achieved a pooled AUC of 0.…
An AI blood test could spot early breast cancer in 81% of cases with 87% accuracy, but mixed study methods mean it should only help doctors …
Simulation study suggests BF-BOLD reduces overdose rates and enhances safety in Phase I trials compared to conventional designs
Can a smarter trial design make early cancer drug tests safer and more sustainable?
This Phase I simulation study compared the Backfill Bayesian Ordered Lattice Design (BF-BOLD) against conventional Phase I trial designs.
A smarter trial design reduces overdose rates and improves safety while preserving drug effectiveness during early cancer tests.
Neoadjuvant chemotherapy plus sintilimab improved response rates versus chemotherapy alone in 61 patients with triple-negative breast cancer
Combination therapy improved response rates in a small study of triple-negative breast cancer patients
This retrospective cohort study evaluated 61 patients with triple-negative breast cancer (TNBC) receiving neoadjuvant therapy at a single ce…
Adding the immunotherapy drug sintilimab to standard chemotherapy boosted response rates and slowed tumor growth in triple-negative breast c…
Hospitalized malignant neoplasm patients show high comorbidity burden and distinct disease patterns across 163 Chinese hospitals
Hospitalized cancer patients in China often have other serious health conditions
This retrospective cohort study examined 107,029 hospitalized patients with malignant neoplasms across 163 hospitals in Zhanjiang, China.
Hospitalized cancer patients in China often face five other serious health conditions, with rural residents, men, and those aged 65 or older…
Radiomics and AI show promise for cervical cancer radiotherapy but face validation and standardization challenges
AI tools show promise for cervical cancer radiotherapy but need more testing
This narrative review examines the application of radiomics and artificial intelligence (AI) in precision radiotherapy for women with cervic…
AI tools show promise for cervical cancer radiotherapy but need more testing before becoming standard care for patients.
Radiotherapy associated with improved response and survival in HCC patients receiving immune-targeted therapy
Does adding radiation help some liver cancer patients respond better to their immune therapy?
A multicenter retrospective study of 238 HCC patients receiving immune-targeted therapy found radiotherapy was associated with higher object…
Adding radiation to immune therapy helped more advanced liver cancer patients see their tumors shrink and live longer compared to those who …
Pyroptosis-related gene signature predicts prognosis in triple-negative breast cancer patients
Can a gene signature predict survival for triple-negative breast cancer patients?
This observational cohort study analyzed data from TCGA and GEO databases, validated in an independent GEO cohort and 48 clinical samples, t…
A genetic warning system in triple-negative breast cancer tumors can predict which patients face a higher risk of the cancer returning.