Computational framework reconstructs multidimensional clinical profiles from published Kaplan-Meier images
Can a computer reconstruct hidden patient stories from old cancer trial charts?
Methodological research using simulated data and empirical cancer cohorts (n=228 lung, n=929 colon) evaluated the MD-JoPiGo framework.
A new tool reconstructs hidden patient stories from old cancer trial charts, revealing how age and tumor markers interacted using only stand…
Systematic review finds highest glyphosate exposure associated with increased NHL risk
Higher glyphosate herbicide exposure linked to increased lymphoma risk in research review
A systematic review and meta-analysis of 20 observational study populations found that ever exposure to glyphosate-based herbicides was not …
People with the highest glyphosate herbicide exposure had about a 38% higher chance of developing non-Hodgkin's lymphoma compared to those w…
Network meta-analysis compares image-enhanced endoscopy techniques for colorectal lesions
Which colonoscopy technique works best for spotting suspicious growths?
A network meta-analysis of randomized controlled trials compared various image-enhanced endoscopy techniques for colorectal lesion detection…
Doctors have many high-tech tools to look for growths during a colonoscopy, but it's unclear which one is best.
Deep learning model using preoperative CT predicts lymph node metastasis in papillary thyroid carcinoma
Can a new AI model help thyroid cancer patients avoid unnecessary surgery?
A retrospective cohort study of 1560 PTC patients developed and validated ThyLNT, a Transformer-based 2.5D deep learning model using preoper…
A new AI model predicts lymph node spread in thyroid cancer better than standard scans, potentially sparing patients from unnecessary surger…
Nomogram predicts moderate-to-severe complications after primary tumor resection in metastatic colorectal cancer
Study identifies four factors linked to surgical complications in metastatic colorectal cancer
A retrospective single-institution cohort study of 404 metastatic colorectal cancer patients undergoing primary tumor resection identified a…
Older age, low albumin, tumor location, and long surgery time raise complication risks for metastatic colorectal cancer patients.
Sentinel Node Biopsy Associated with Reduced Melanoma Mortality and Recurrence in Meta-Analysis
Does checking lymph nodes help people with melanoma live longer?
A systematic review and meta-analysis of 13 studies with 40,287 adults with melanoma found sentinel node biopsy (SNB) was associated with a …
Checking lymph nodes during melanoma diagnosis is linked to a lower risk of dying from the cancer and less chance of it returning.
Lu-PSMA-617 plus pembrolizumab shows PSA response in mCRPC phase 1b/2 trial
Can a new drug combo help men with advanced prostate cancer?
In a single-arm phase 1b/2 trial of 37 patients with mCRPC, Lu-PSMA-617 plus pembrolizumab achieved a 50% PSA decline in 28 participants (76…
A new drug combo helped 28 of 37 men with advanced prostate cancer cut their PSA levels in half while keeping side effects mostly mild to mo…
Ifinatamab deruxtecan shows antitumor activity in advanced treatment-refractory solid tumors in phase 1/2 trial
Early trial shows experimental drug shrinks tumors in some patients with advanced cancers
This first-in-human phase 1/2 trial of 97 patients with advanced treatment-refractory solid tumors found a confirmed objective response rate…
An early trial of a new experimental drug shrank tumors in 34% of patients with advanced cancers that had stopped responding to standard tre…
Case report: Low-intensity chemotherapy achieves remission in PMF transformed to MPAL
Single case report describes treatment for rare leukemia transformation in elderly patient
A case report describes a 75-year-old female with JAK2V617F-positive primary myelofibrosis that transformed to mixed phenotype acute leukemi…
A 75-year-old woman with rare leukemia transformation from blood disorder achieved remission after two cycles of low-intensity chemotherapy.
Fulzerasib plus cetuximab shows 69% response in first-line KRAS-mutated NSCLC
Can a new drug combination shrink lung tumors in people with a specific KRAS mutation?
A single-arm phase 1b/2 trial in 47 treatment-naive patients with KRAS-mutated NSCLC found a confirmed objective response rate of 69% (90% C…
A new two-drug combination shrank tumors in nearly 70% of people with advanced lung cancer driven by a specific genetic mutation.
Radiomics models predict progression in lung oligometastases after SABR in phase II trial
Radiomics models show promise for predicting outcomes after lung metastasis radiation
A single-arm phase II trial of 126 patients with lung oligometastases developed radiomics models to predict progression-free survival and ea…
Computer analysis of medical scans can better predict when lung cancer will spread after radiation treatment than standard clinical informat…
Real-world study shows lenalidomide-dexamethasone yields 22.9-month PFS in transplant-ineligible myeloma
Real-world study shows lenalidomide treatment outcomes for older multiple myeloma patients
A prospective, non-interventional study of 168 transplant-ineligible NDMM patients in Germany found median PFS of 22.9 months and OS of 58.1…
Real-world data shows lenalidomide plus low-dose dexamethasone keeps older multiple myeloma patients disease-free for nearly two years while…