Phase 3 trial of navitoclax plus ruxolitinib versus ruxolitinib alone in myelofibrosis posts results
Phase 3 trial tests navitoclax with ruxolitinib for myelofibrosis spleen volume
A phase 3 randomized controlled trial in 252 adults with myelofibrosis compared navitoclax plus ruxolitinib to ruxolitinib plus placebo.
A new drug combination aims to shrink painful enlarged spleens in myelofibrosis patients, but results from this large global trial are not y…
Modeling study predicts human pharmacokinetics for TAK-500, an anti-CCR2 antibody-drug conjugate
Early modeling study predicts how a new cancer drug candidate might behave in humans
A preclinical and clinical modeling study used cynomolgus monkey data and human parental antibody data to simulate human pharmacokinetics fo…
A computer model predicts that a new cancer drug stays in the body longer as the dose increases, helping scientists plan safe first-in-human…
FDA Approves Zynyz (retifanlimab-dlwr) for Metastatic Anal Canal Cancer and Merkel Cell Carcinoma
FDA approves new drug Zynyz for two rare and aggressive types of cancer
The FDA has approved Zynyz, a PD-1 blocking antibody, for two indications: first-line treatment of inoperable locally recurrent or metastati…
FDA approves new drug Zynyz to treat two rare and aggressive cancers: advanced anal cancer and Merkel cell carcinoma.
Envafolimab plus lenvatinib and capecitabine shows activity in resected biliary tract cancer
Combination therapy shows promise for preventing biliary tract cancer recurrence after surgery
A single-arm phase II trial in 28 patients with resected biliary tract cancer at high risk of recurrence found median disease-free survival …
A new three-drug combination helped 68% of high-risk biliary tract cancer patients stay cancer-free for a year after surgery, with 91% still…
Hypoxia in solid tumors drives metabolic reprogramming, immune suppression, and therapeutic resistance
How do tumors survive in low oxygen? They completely change how they eat
A systematic review synthesizing evidence on hypoxia in solid tumors found that low oxygen tension orchestrates metabolic reprogramming thro…
When tumors run out of oxygen, they switch diets to eat fat and glutamine, becoming more invasive, acidic, and resistant to treatment.
FDA Approves Focinvez (fosaprepitant) for Prevention of Chemotherapy-Induced Nausea and Vomiting
FDA approves a new intravenous drug to help prevent nausea and vomiting from chemotherapy
The FDA has approved Focinvez, a substance P/NK1 receptor antagonist, for the prevention of acute and delayed nausea and vomiting associated…
FDA approves new IV drug to prevent severe nausea and vomiting from chemotherapy in adults and children 6 months and older.
Larger baseline tumor burden linked to shorter OS in rare cancers treated with nivolumab plus ipilimumab
Does tumor size predict how well immunotherapy works for rare cancers?
A secondary analysis of a phase 2 basket trial in 722 patients with rare/ultrarare malignancies found that larger baseline tumor burden was …
For rare cancers treated with immunotherapy, larger tumors at the start were linked to shorter overall survival, but not to how long patient…
Phase 2 trial links early monocyte elevation to response in gastric cancer immunotherapy
Small study finds immune cell changes linked to better response in gastric cancer treatment
A phase 2 trial in 24 patients with metastatic gastric cancer receiving first-line pembrolizumab plus XELOX found that early elevation of ci…
Patients with metastatic gastric cancer who saw early immune cell changes in their blood were more likely to survive longer while receiving …
VLSM analysis of 350 meningioma resections links tumor location to histology, symptoms, and surgical outcomes
Brain tumor location patterns linked to symptoms and surgical outcomes in study
A retrospective, single-center cohort of 350 patients who underwent meningioma resection found that voxel-based lesion symptom mapping (VLSM…
Brain tumor location in the brain is linked to specific symptoms and how well surgery removes the growth, according to a new study.
Feasibility trial shows ePRO-led survivorship care may improve symptoms in early-stage cancer patients
Digital symptom tracking shows promise for cancer survivors in early trial
A feasibility RCT of 200 women with early-stage breast or gynecologic cancer tested a 12-month ePRO-led multidisciplinary intervention versu…
A digital health program helped recent cancer survivors in Ireland report less fatigue, anxiety, and depression while improving their qualit…
Corticosteroid therapy associated with greater weight loss and poorer appetite in advanced pancreatic cancer
Corticosteroid therapy linked to more weight loss in advanced pancreatic cancer patients
A post hoc analysis of the MISTRAL trial in 244 patients with advanced pancreatic cancer found corticosteroid therapy was associated with gr…
Corticosteroid therapy linked to more weight loss in advanced pancreatic cancer patients, who also reported less appetite and lower BMI duri…
Meta-analysis: Preoperative calcitonin predicts lateral cervical lymph node metastasis in medullary thyroid carcinoma
Can a simple blood test help surgeons plan thyroid cancer operations?
A meta-analysis of 8 studies (951 patients) with medullary thyroid carcinoma found preoperative serum calcitonin demonstrated good diagnosti…
A simple blood test measuring calcitonin levels can accurately predict if medullary thyroid cancer has spread to neck lymph nodes before sur…