Histology-derived gene-expression signatures predict distant recurrence-free interval and chemotherapy benefit in early breast cancer cohorts
New Tool Predicts Breast Cancer Recurrence From Old Slides
This multi-cohort study evaluated histology-derived gene-expression signatures from routine hematoxylin and eosin slides compared with clini…
A simple AI analysis of old biopsy slides can now predict which breast cancer patients face higher risk of recurrence and who truly benefits…
Baseline Cytokine Levels Linked to Placebo Response in Cancer Dyspnea Trial
High Inflammation Might Reduce Placebo Effect in Cancer
This exploratory analysis of an RCT in 45 cancer patients with dyspnea found a negative association between baseline cytokine levels and sym…
Scientists found that high inflammation levels may stop the placebo effect from working well.
Narrative review discusses adapter-based CAR T cells for solid tumors and hematological malignancies
Adapter-based CAR T cells face hurdles in treating solid tumors and blood cancers
This narrative review examines the potential of adapter-based CAR T cells across multiple cancer types, including solid tumors and hematolog…
A review highlights that making these cells is hard work and they struggle against solid tumors, limiting their current use.
Tisagenlecleucel in Korean patients with relapsed or refractory diffuse large B-cell lymphoma
New Lymphoma Therapy Helps Patients Live Longer
This retrospective cohort study of 79 Korean patients with relapsed or refractory diffuse large B-cell lymphoma evaluated tisagenlecleucel.
A new study shows a specific immune therapy can shrink tumors and extend life for lymphoma patients who have run out of options.
Ultrasound radiomics features aid preoperative differentiation of granulomatous lobular mastitis and breast cancer in a retrospective cohort
Ultrasound Can Spot This Breast Condition Before Surgery
This retrospective cohort study evaluated ultrasound radiomics features in 237 patients with granulomatous lobular mastitis or breast cancer…
Many women face a scary moment when a lump appears in their breast.
CIPHER model predicts immune checkpoint inhibitor pneumonitis risk in non-small cell lung cancer patients
Lung Scans Can Now Predict Dangerous Side Effect Before Treatment
This cohort study evaluated a CIPHER model versus classical radiomic models for predicting immune checkpoint inhibitor-induced pneumonitis i…
This tool could help doctors protect patients before a serious side effect strikes.
Meta-analysis identifies new genetic loci linked to acute myeloid leukemia risk in 4710 cases
New Genetic Map Reveals Hidden Leukemia Risk Factors
This meta-analysis evaluated common genetic variants at 1q23.3, 2p23.3, 2q33.3, and 2p21 in 4710 AML cases and 12,938 controls.
New research pinpoints specific DNA changes that raise the odds of developing acute myeloid leukemia.
Systematic review of cold vs warm sodium hypochlorite irrigation for postoperative pain in root canal therapy
Cold Rinse Cuts Tooth Pain After Root Canals
This narrative systematic review evaluates postoperative pain in patients undergoing root canal therapy using cold versus warm or room tempe…
A simple change in root canal care—using a cold rinse instead of warm—could reduce pain in the first hours after treatment, offering relief …
Machine learning quantification of Gleason Pattern 4 showed higher discrimination for adverse pathology than grade group in prostate cancer
AI Measures Prostate Cancer Risk More Accurately Than Standard Methods
This proof-of-principle cohort study evaluated 726 patients with grade group 2-4 prostate cancer on systematic biopsy who underwent radical …
A new AI tool can spot dangerous prostate cancer patterns better than current grading, offering men a clearer picture of what to expect afte…
Plasma lipid panel and machine learning for non-invasive early breast cancer detection
Researchers find blood test spots early breast cancer
This observational cohort study used a 15-lipid panel and machine learning to detect early-stage breast cancer in women across international…
A new blood test using lipids and machine learning shows promise for detecting early-stage breast cancer, with strong results in European an…
Narrative review explores exosomal non-coding RNAs in osteoarthritis pathogenesis and therapy
Tiny Messengers in Your Joints Could Change Osteoarthritis Care
This narrative review summarizes the role of exosomal non-coding RNAs in osteoarthritis.
Scientists are learning how to use your body’s own tiny messengers to calm inflamed joints and potentially slow osteoarthritis.
Narrative review discusses NTS1-targeted molecular probes for malignancies with noted translation challenges
New Cancer Scan Targets Tumors Hidden from View
This narrative review examines the potential of NTS1-targeted molecular probes for treating malignancies.
Researchers are building a smarter tool to find and treat cancer cells more accurately.