Busulfan-based conditioning favors survival in AML while TBI yields better outcomes in ALL
Busulfan Shows Survival Benefits for Patients with Acute Myeloid Leukemia
This meta-analysis of 26 studies compared Busulfan-based conditioning to total body irradiation for children and young adults undergoing hem…
Busulfan may offer better survival for certain leukemias while reducing long-term side effects like growth issues and cataracts in young pat…
PLEX and corticosteroids show highest clinical response rates in chronic inflammatory demyelinating polyradiculoneuropathy
New FcRn Inhibitors Show Promise for Chronic Inflammatory Neuropathy
This systematic review and network meta-analysis of 2,184 patients evaluated various treatments for chronic inflammatory demyelinating polyr…
Newer treatments like efgartigimod alfa may offer significant clinical responses and improved grip strength for patients with chronic inflam…
Adjunctive corticosteroids do not significantly reduce coronary artery abnormalities in patients with Kawasaki disease
Adding corticosteroids to Kawasaki disease treatment shows mixed results
This meta-analysis of 4106 patients evaluated adjunctive corticosteroids for Kawasaki disease. The study found no significant difference in …
Adding corticosteroids to standard Kawasaki disease treatment may shorten hospital stays but does not change heart health outcomes.
Multifactorial risk factors and preventive strategies for children with precocious puberty
Identifying Key Risk Factors for Children with Precocious Puberty
This narrative review synthesizes risk factors for precocious puberty across eight domains including genetic, environmental, and lifestyle f…
New research identifies eight different areas, from genetics to lifestyle, that may influence the risk of early puberty in children.
PDA closure rates decrease significantly after second and third courses of cyclooxygenase inhibitors in preterm infants
Repeated drug courses show lower closure rates for heart defects
This meta-analysis of 33 studies evaluates the efficacy of repeated cyclooxygenase inhibitor courses for Patent Ductus Arteriosus (PDA) clos…
New data shows that preterm infants may have lower rates of heart defect closure after multiple rounds of medication.
Intraoperative traction shows favorable but imprecise association with correction rates in adolescent idiopathic scoliosis
Intraoperative Traction Shows Potential for Scoliosis Correction Rates
This meta-analysis of 4 studies involving 450 participants evaluated intraoperative traction for adolescent idiopathic scoliosis. The analys…
A review of surgical data suggests that intraoperative traction may improve correction rates for adolescents with scoliosis, though evidence…
Schroth and bracing show a trend toward better short-term Cobb angle control in adolescent idiopathic scoliosis
Bracing and Schroth Training Show Promise for Scoliosis Control
This network meta-analysis of 709 patients evaluated various non-surgical interventions for adolescent idiopathic scoliosis. The analysis fo…
New analysis suggests that bracing and Schroth training may help manage the Cobb angle in adolescents with idiopathic scoliosis.
Prophylactic oral antibiotics do not reduce cholangitis incidence in patients with biliary atresia
Antibiotics do not prevent infection after Kasai portoenterostomy surgery
This meta-analysis of 516 patients with biliary atresia who underwent Kasai portoenterostomy found that prophylactic oral antibiotics did no…
New data shows that giving oral antibiotics does not prevent infections in children with biliary atresia after surgery.
Synchronized nasal intermittent positive pressure ventilation reduces extubation failure in preterm infants with respiratory distress
Synchronized Ventilation May Reduce Extubation Failure in Preterm Infants
This meta-analysis evaluated the impact of synchronized nasal intermittent positive pressure ventilation on extubation failure and respirato…
A new analysis suggests that synchronized nasal ventilation helps preterm infants breathe easier and reduces the risk of failing to breathe …
Off-label growth hormone yields catch-up growth in Takenouchi-Kosaki syndrome case
Growth Hormone Shows Early Promise in Rare Genetic Syndrome
This case report describes a pediatric patient with Takenouchi-Kosaki syndrome (CDC42 p.Arg68Gln variant) treated off-label with recombinant…
A single case report describes catch-up growth in a child with Takenouchi-Kosaki syndrome after growth hormone treatment.
Self-weaning shows no significant difference from dose-adjusted weaning in caffeine duration for apnea of prematurity
Caffeine weaning methods show no difference for preterm infants
This prospective cohort study of 204 preterm infants found no significant difference between self-weaning and dose-adjusted weaning for caff…
New data suggests that simplifying how doctors taper caffeine for preterm babies may be just as effective as complex dose adjustments.
PMSA-2025 screening tool achieves high content validity for identifying mild malnutrition in children
New screening tool helps identify mild malnutrition in young children
This guideline provides a consensus-based refinement and validation of the PMSA-2025 pediatric malnutrition screening algorithm. The tool ac…
A new screening tool helps doctors and community workers identify children with mild malnutrition risk in outpatient and community settings.