Azithromycin at discharge does not reduce pneumococcal carriage in Kenyan children
A Single Dose Does Not Boost Drug Resistance
A randomized trial found a 5-day azithromycin course at hospital discharge did not lower pneumococcal carriage or resistance rates in Kenyan…
Giving a five-day course of azithromycin to children leaving the hospital did not increase drug resistance or change bacteria levels.
Narrative review on pediatric perianal abscess management and fistula risk
Skip the Scalpel for Baby Bottom Abscesses Doctors Now Advise
This narrative review synthesizes evidence on surgical and conservative management of pediatric perianal abscesses. It notes rapid symptom r…
• Infants heal abscesses with antibiotics not surgery often • Helps parents of babies with painful bottom lumps • Doctors must confirm it is…
Systematic review and meta-analysis compares Rome III and Rome IV criteria for functional abdominal pain disorder prevalence
New Rome IV rules show fewer people have functional abdominal pain compared to older guidelines
This systematic review and meta-analysis evaluates the prevalence of functional abdominal pain disorder (FAPD) and its subtypes using Rome I…
A big review found that using newer rules makes it look like fewer people have stomach pain problems. This change happens because the new ch…
Meta-analysis finds antibiotics alone comparable to drainage for pediatric post-appendectomy abscess
Antibiotics Alone Work As Well As Surgery For Kids' Abscesses
This meta-analysis of observational studies compared antibiotics alone versus invasive drainage for pediatric post-appendectomy abscess. Tre…
• Antibiotics succeed where surgery was once required • Helps stable children after appendix removal • Not for severe cases
Meta-analysis finds coaching improves teacher practice and child outcomes in early childhood settings
Coaching Young Children Works Better Than We Thought
This meta-analysis of 112 studies synthesizes evidence on coaching for teachers in early childhood settings. It reports positive, medium-to-…
A new analysis of 112 studies shows that coaching early childhood teachers boosts children's learning in reading, behavior, and math more th…
FDA Approves Dextrose 5% Injection for Hydration and Calorie Source
FDA approves dextrose 5% injection for hydration and as drug diluent
FDA approved Dextrose 5% Injection for use as a source of calories and water for hydration in adults and pediatric patients. It is also indi…
The FDA approved Dextrose 5% Injection to provide calories and water for hydration in adults and children. It can also be used to mix with o…
Systematic review and meta-analysis on postoperative dysglycemia prevalence in pediatric cardiac surgery
High rate of blood sugar issues after children heart surgery
This systematic review and meta-analysis synthesized data on postoperative dysglycemia in 3864 pediatric cardiac surgery patients. The poole…
A major review found most kids have blood sugar problems after heart surgery. This can lead to longer hospital stays.
Narrative review on pediatric otitis media risk factors and biomarkers
Kids Ear Infections Depend on Home Dust and Genes Together
This narrative review synthesizes evidence on environmental exposures, host genetic susceptibility, biomarkers, and microbial factors in ped…
• Ear infections stem from home environment, genes, and germs interacting • Helps families with children suffering repeated painful ear infe…
Meta-analysis provides normative pediatric sleep data across age groups
New Sleep Ranges for Healthy Kids Based on Age and Sex
This meta-analysis of 2947 healthy children provides normative polysomnographic parameters. Most sleep measures decreased with age, while aw…
New sleep ranges for healthy children could help doctors spot real sleep problems sooner.
Narrative review examines neuropsychiatric manifestations of celiac disease in pediatric and adult populations
Gluten-free diets help some people with celiac disease feel better but not everyone gets better
This narrative review examines neuropsychiatric manifestations associated with celiac disease in pediatric and adult populations. The author…
People with celiac disease often have brain and mood problems. A gluten-free diet helps some, but others still feel sick even after followin…
Review synthesizes IQSEC2 variant features in developmental encephalopathy and Rett-like syndrome cases
New Clue Solves Mystery Behind Boys With Rett-Like Symptoms
This case report and literature review synthesizes data from two brothers, their mother, and 38 published cases of IQSEC2-related conditions…
• IQSEC2 gene mutations explain Rett-like symptoms in boys • Helps families with undiagnosed developmental delays and seizures • Genetic tes…
Narrative review finds insufficient evidence for CFTR modulator monotherapy in cystic fibrosis with F508del homozygosity
New review shows single drug therapy does not help people with cystic fibrosis who have two F508del gene variants
This narrative review synthesized evidence from 10 early-phase trials on CFTR modulator monotherapy for cystic fibrosis with F508del homozyg…
A review of early studies found that taking one CFTR modulator drug alone does not improve survival, lung function, or quality of life for p…