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Mini-PCNL and standard PCNL show comparable stone-free rates in pediatric patients with nephrolithiasisMini-PCNL and Standard PCNL Show Similar Success for Kidney Stones

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Key Takeaway
Note that mini-PCNL and standard PCNL offer comparable stone-free rates in pediatric patients with nephrolithiasis.

This meta-analysis evaluated the efficacy and safety of mini-PCNL compared to standard PCNL in a population of 490 pediatric patients with nephrolithiasis. The primary outcome, stone-free rate, was comparable between the two procedures (RR 0.98; 95% CI 0.929-1.041; p = 0.56).

Secondary outcomes revealed that mini-PCNL was associated with a lower risk of Clavien-Dindo grade I complications (RR 0.464; 95% CI 0.442-0.944; p < 0.05). However, mini-PCNL was associated with significantly longer operative times (MD 7.5 min; 95% CI 0.2-14.9; p = 0.04). No significant differences were found regarding postoperative fever or Clavien-Dindo grade II-IV complications.

The authors noted high heterogeneity in the data regarding operative time (I2 = 78%). Clinically, while both procedures achieve similar stone-free rates, mini-PCNL may reduce minor complications but requires more time in the operating room. These findings suggest that the choice between mini-PCNL and standard PCNL may depend on surgeon preference regarding operative duration versus the risk of minor complications.

How this fits prior evidence

This meta-analysis addresses a gap in comparing specific surgical techniques for pediatric nephrolithiasis. It complements existing evidence regarding suction-assisted PCNL, which improves perioperative outcomes, and active stone-directed interventions, which reduce recurrence for asymptomatic stones. This study specifically confirms that mini-PCNL provides comparable stone-free rates to standard PCNL, while highlighting a trade-off between lower grade I complications and longer operative times.

A meta-analysis of 490 pediatric patients compared two surgical methods for treating kidney stones: mini-PCNL and standard PCNL. The study looked at how well each method cleared stones, how long the surgeries took, and the types of complications patients experienced.

The results showed that both methods were equally effective at achieving a stone-free rate. While mini-PCNL procedures took about 7.5 minutes longer on average, they were associated with a lower risk of minor complications (Clavien-Dindo grade I). There was no significant difference between the two methods regarding postoperative fever or more serious complications (Clavien-Dindo grade II-IV).

Because this is a meta-analysis of various study types, the results should be viewed as an overview of current data rather than a guarantee for every patient. The findings suggest that while the surgical time differs, the primary goal of removing the stone is achieved by both methods. Patients and families can discuss these specific trade-offs with their doctors to choose the best approach for their situation.

What this means for you:
Both mini-PCNL and standard PCNL are equally effective at clearing kidney stones in children.

Common questions

Are both procedures equally effective at removing stones?

Yes, the study found that both mini-PCNL and standard PCNL achieved comparable stone-free rates in pediatric patients. This means both methods were equally successful at the primary goal of removing the kidney stones.

What are the differences in complications between the two methods?

Mini-PCNL was associated with a lower risk of minor complications (Clavien-Dindo grade I). However, there was no significant difference between the two methods regarding postoperative fever or more serious complications (Clavien-Dindo grade II-IV).

How does the surgery time differ between mini-PCNL and standard PCNL?

The study found that mini-PCNL procedures took longer on average, with a mean difference of 7.5 minutes compared to standard PCNL. This difference in timing was noted even though the success rates remained similar.

Study Details

Study typeMeta analysis
Sample sizen = 490
EvidenceLevel 1
PublishedJan 2026
View Original Abstract ↓
BACKGROUND: Although miniaturized percutaneous nephrolithotomy (mini-PCNL) is a less invasive alternative to standard percutaneous nephrolithotomy (PCNL), its comparative outcomes in pediatric patients remain unclear. OBJECTIVES: To compare the efficacy and safety of mini-PCNL versus standard PCNL in children with nephrolithiasis. DESIGN AND SETTING: Systematic review and meta-analysis conducted according to PRISMA guidelines, including randomized controlled trials (RCTs) and retrospective cohort studies of pediatric patients undergoing mini-PCNL or standard PCNL. METHODS: Major databases (Cochrane Library, PubMed/MEDLINE, and Embase) were searched through August 2024. The primary endpoint was the stone-free rate. Secondary endpoints included operative time, postoperative fever, and complications classified by the Clavien-Dindo system. RESULTS: Five studies (two RCTs and three retrospective cohort studies) involving 490 patients (46% underwent mini-PCNL) were included. Stone-free rates were comparable between the groups (relative risk [RR], 0.98; 95% confidence interval [CI], 0.929-1.041; p = 0.56; I2 = 0%). Mini-PCNL was associated with longer operative times (mean difference [MD], 7.5 min; 95% CI, 0.2-14.9; p = 0.04; I2 = 78%) but a lower risk of Clavien-Dindo grade I complications (RR 0.464; 95% CI 0.442-0.944; p < 0.05; I2 = 0%). No significant differences were observed in postoperative fever or Clavien-Dindo grade II-IV complications. CONCLUSION: Mini-PCNL and standard PCNL achieve comparable stone-free rates in pediatric patients. Mini-PCNL is associated with fewer minor complications, whereas standard PCNL is associated with shorter operative times. Both techniques demonstrate similar safety profiles with respect to major complications. CLINICAL TRIAL OR SYSTEMATIC REVIEW REGISTRATION: PROSPERO: CRD42024618399; available at: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024567890.
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