Art therapy reduces depressive symptoms significantly in adults with depression compared with control conditions
Art therapy significantly reduces depression symptoms in adults compared to standard care
This systematic review and meta-analysis evaluated art therapy for adults with depression in community settings. Eight hundred sixty-one par…
A new analysis of art therapy shows it significantly reduces depression symptoms in adults. This promising approach offers hope for those se…
Brexpiprazole improves PANSS scores by 0.19 Cohen's d in early-episode schizophrenia versus placebo
Brexpiprazole helps early schizophrenia symptoms more than placebo in adults and teens
This post hoc analysis of Phase 3 trials evaluated brexpiprazole versus placebo in 476 adults and adolescents aged 13-35 years with early-ep…
A look at trial data shows brexpiprazole improved symptoms and daily functioning better than placebo for people with early schizophrenia.
Aromatherapy and music therapy significantly reduce anxiety and pain during mandibular third molar extraction surgery in patients
Music and aromatherapy reduce anxiety during dental surgery
This randomized controlled trial evaluated nonpharmacological interventions for patients undergoing mandibular third molar extraction. Both …
Patients undergoing wisdom tooth removal felt less anxious and reported lower pain when given music or aromatherapy compared to standard car…
Short allele of 5-HTTLPR linked to increased schizophrenia risk in Japanese cohort and meta-analysis
Short gene variant linked to schizophrenia risk in Japanese ancestry patients
This cohort study and meta-analysis in Japanese patients found a significant association between the 5-HTTLPR short allele and schizophrenia…
A specific gene variant appears more common in people with schizophrenia than in controls, suggesting a possible link to disease risk.
Gut microbiome dysbiosis links to depression across distinct thematic domains in computational meta-analysis
Gut microbiome linked to depression in new review
This computational meta-analysis review synthesizes literature on gut microbiome dysbiosis in depression, identifying distinct interconnecte…
A new review maps how gut bacteria may influence depression through immune, metabolic, and brain pathways.
Massage improves menopause symptoms in systematic review and meta-analysis
Massage helps menopausal women feel better on many key measures
This systematic review and meta-analysis found that massage therapy significantly improves menopause-related symptoms, including total MRS s…
A review found massage significantly improved mood, fatigue, and hot flashes for menopausal women, though effects varied by specific symptom…
Exercise interventions significantly reduced depressive symptoms in adults with lung and digestive cancer across eight randomized controlled trials
Exercise may reduce depressive symptoms in adults with lung and digestive cancer
This meta-analysis of randomized controlled trials evaluated exercise interventions versus control conditions in adults with lung and digest…
A meta-analysis of eight trials suggests exercise significantly reduces depressive symptoms in adults with lung and digestive cancer compare…
Cocaine use disorder prevalence in bipolar disorder is 10.94 percent with worse clinical outcomes
One in ten people with bipolar disorder also struggles with cocaine use
This systematic review and meta-analysis of 6,150,881 individuals with bipolar disorder found a pooled overall prevalence of cocaine use dis…
A large review found that 11 percent of people with bipolar disorder also have cocaine use disorder, a number that jumps to 46 percent in sp…
Machine learning models show moderate predictive accuracy for CBT depression outcomes in external validation
Machine learning predicts depression treatment outcomes in most studies
This systematic review and meta-analysis of 11,733 patients found machine learning models predicting CBT outcomes for depression showed repl…
A large analysis of 11,733 patients found machine learning models can predict how cognitive behavioral therapy works for depression in most …
Pimavanserin adjunctive therapy shows small statistically significant reductions in PANSS scores below clinically meaningful thresholds for schizophrenia
Review finds pimavanserin offers little for schizophrenia negative symptoms
This systematic review and meta-analysis evaluated adjunctive pimavanserin in 1676 randomized participants with schizophrenia. The analysis …
A major review of 1,676 adults with schizophrenia found adding pimavanserin did not meaningfully improve negative symptoms, despite small st…
First case report links zonisamide to homicidal ideation in epilepsy patient
First case report links zonisamide to homicidal thoughts in an epilepsy patient
A case report and literature review describes a patient with epilepsy who developed homicidal ideation during zonisamide uptitration. Sympto…
A patient developed homicidal thoughts after taking zonisamide. This rare case highlights a serious psychiatric side effect of the drug that…
Emotion decoding deficits in older adults with depression may reflect impaired recognition, not hypersensitivity
Mixed signals on how depression affects emotional processing in older adults
This commentary critiques a meta-analysis on emotion recognition in older adults with major depressive disorder. It argues that negative sta…
A commentary suggests depression might impair how older adults decode emotions, but study selection heavily influences these conclusions.