Immuno-kynurenine shifts track cognitive change in antipsychotic-naive first-episode schizophrenia
New Brain Signals Show Why Early Treatment Works
A longitudinal observational study of antipsychotic-naive first-episode schizophrenia patients and healthy controls examined peripheral infl…
Early treatment for schizophrenia clears thinking fog by fixing brain chemistry and immune signals that cause mental confusion before scary …
Medically supervised ketogenic diet shows preliminary efficacy for moderate to severe major depressive disorder in a pilot trial
Ketogenic Diet May Ease Severe Depression
This open-label, single-arm pilot feasibility trial evaluated a medically supervised ketogenic diet (MSKD) in 11 individuals with moderate t…
A low-carb, high-fat diet helped most participants maintain ketosis and showed promise for treating moderate to severe depression in a new p…
FDA Approves Concerta (methylphenidate) for ADHD in Patients Aged 6 to 65 Years
The FDA approved a new once-daily ADHD medication called Concerta for people ages 6 to 65
Concerta (methylphenidate) is approved for the treatment of attention deficit hyperactivity disorder (ADHD) in patients aged 6 to 65 years.
The FDA approved Concerta, a once-daily ADHD medication, for people ages 6 to 65 to help manage symptoms throughout the day with a single do…
Prochlorperazine Labeling: Indicated for Severe Nausea/Vomiting and Schizophrenia
The FDA approved a new injection to treat severe nausea and schizophrenia when pills cannot be taken
FDA labeling for prochlorperazine lists two approved indications: control of severe nausea and vomiting and treatment of schizophrenia.
A new FDA-approved injection now treats severe nausea and schizophrenia when patients cannot take pills by mouth.
Pharmacogenomic-guided treatment showed age-dependent cognitive benefits in depressive disorder patients
Can a Cheek Swab Pick the Right Antidepressant for You?
This single-center randomized controlled trial enrolled 843 patients with depressive disorder stratified by age.
A DNA test that guides antidepressant choice lifted mood and sharpened thinking in young patients, but gave almost no brain-function boost t…
Network meta-analysis of acupoint stimulation therapies for primary insomnia in 7,628 patients
Acupuncture for Insomnia: Which Type Works Best?
This systematic review and network meta-analysis evaluated 14 acupoint stimulation therapies for primary insomnia involving 7,628 patients.
A major analysis of nearly 8,000 patients found that combining body acupuncture with electroacupuncture ranked highest for improving insomni…
Plasma NfL levels elevated in bipolar and depressive disorders in UK Biobank cohort
Brain Scans Show Hidden Signals in Mental Health
A cohort study of 47,495 UK Biobank participants found plasma neurofilament light chain (NfL) levels were higher in bipolar disorder (d=0.20…
Blood tests now reveal hidden brain signals that distinguish depression from anxiety, offering clearer paths to the right treatment for mill…
Meta-analysis finds tDCS does not significantly improve core ADHD symptoms in 1,864 patients
Can Mild Brain Stimulation Really Treat ADHD?
A systematic review and meta-analysis of 1,864 patients with ADHD found transcranial direct current stimulation (tDCS) did not significantly…
A fresh look at 28 studies of mild brain stimulation for ADHD finds it does not reliably improve symptoms, though one specific setup showed …
Anti-inflammatory diets show mental health benefits in adults, with most consistent improvements in depressive symptoms
Anti-inflammatory diets may help improve depression symptoms in adults with mental health issues
A scoping review of 42 RCTs and 23 systematic evidence syntheses in adults found that anti-inflammatory dietary interventions, such as Medit…
Adults with depression saw better mental health outcomes when following anti-inflammatory diets like the Mediterranean or DASH plans compare…
Systematic review and meta-analysis of insomnia prevalence and risk factors in patients with coronary heart disease
Half of All Heart Disease Patients Can't Sleep — Here's Why That's Dangerous
This systematic review and meta-analysis evaluated insomnia prevalence and associated factors in 5,928 patients with coronary heart disease.
Half of all heart disease patients suffer from insomnia, a common but rarely treated condition linked to depression, anxiety, and diabetes.
Meta-analysis links Adverse Childhood Experiences to increased risk of Non-suicidal Self-Injury
Why Childhood Pain Predicts Self-Harm
A systematic review and meta-analysis of 13 articles in individuals with Adverse Childhood Experiences (ACEs) found that ACEs, including phy…
Childhood abuse and emotional pain significantly raise the risk of self-harm later in life, urging doctors to treat the root causes instead …
Seven-Dimensional Time Quality of Life Scale correlates with mental health outcomes in psychiatric outpatients aged 12–65 years
How You Experience Time Each Day May Reveal Your Mental Health
This systematic review evaluated the Seven-Dimensional Time Quality of Life Scale (SDT-QoLS) in 608 psychiatric outpatients aged 12–65 years…
A new scale measuring how you feel time passes each day may reveal mental health struggles that standard depression and anxiety tests miss.