mHealth app-supported care pathway did not significantly reduce caregiver state anxiety in ENT surgery cases
Mobile app support shows mixed results for anxious surgery caregivers
This randomized controlled trial of 227 caregivers of children undergoing ENT surgery found no statistically significant difference in careg…
A new trial looks at whether a mobile app can lower anxiety for parents whose children are facing upcoming ear, nose, or throat surgeries.
Platelet-rich plasma shows potential for tissue repair and functional recovery in various nerve injuries
Platelet-rich plasma shows potential for nerve and brain repair
This systematic review evaluates the preclinical potential of platelet-rich plasma (PRP) for treating spinal cord, sciatic, and facial nerve…
Platelet-rich plasma may help repair nerve damage and improve brain function in early studies, though more human testing is needed to ensure…
Silexan shows clinically important adjusted mean value differences of over 0.2 points in MADRS
Lavender Oil Preparation Shows Potential for Treating Depression
This randomized, double-blind, placebo-controlled trial of 498 patients with mild or moderate major depressive disorder found silexan superi…
A clinical trial suggests that a lavender oil preparation called Silexan may help manage symptoms of mild to moderate depression.
Higher baseline PANSS negative symptom severity associated with lower risk of symptom exacerbation
Higher Baseline Negative Symptoms Linked to More Stable Schizophrenia Course
This RCT of 1139 adults with schizophrenia found that patients in the medium and high baseline PANSS negative symptom tertiles had a lower r…
People with schizophrenia who have more severe negative symptoms at the start of treatment may experience fewer sudden flare-ups over 18 mon…
Unified Protocol for Adolescents shows significant treatment effects for hyperactivity and conduct problems
Two School Programs Help Teens' Depression and Anxiety Equally
This randomized controlled trial of 676 adolescents with subthreshold anxiety and depressive symptoms found that the Unified Protocol for Ad…
A 676-teen trial found two group programs worked equally well for depression and anxiety, with one slightly ahead on some behaviors.
Identified barriers and enablers provide evidence based insights for scalable health system transformation strategies
Health system reform: 34 barriers and 27 enablers identified
This systematic review and mixed-methods study identifies 34 barriers and 27 enablers across 6 key areas for health system transformation. T…
A new review pinpoints 34 barriers and 27 enablers that can make or break health system reforms, offering a roadmap for policymakers.
Recurrent implantation failure worsens quality of life and raises depression, anxiety in IVF patients
Recurrent Implantation Failure Linked to Higher Anxiety and Depression
This meta-analysis of 28 studies in couples undergoing ICSI/IVF found that recurrent implantation failure (RIF) is associated with worse qua…
Couples facing repeated pregnancy failures during IVF may experience higher levels of anxiety, depression, and lower quality of life.
Play interventions significantly reduce anxiety and depressive symptoms in children with cancer
Play Interventions Reduce Anxiety and Depression in Children with Cancer
This meta-analysis of 23 studies involving 1541 children with cancer found that play interventions significantly alleviated anxiety (SMD = -…
Play activities like medical play and group play can significantly lower anxiety and depressive symptoms in children undergoing cancer treat…
Meta-analysis finds no atypical reliance on priors in schizophrenia-spectrum psychosis
New findings clarify how the brain processes information in people with schizophrenia
This meta-analysis of behavioral measures found no evidence for atypical reliance on priors in adults with schizophrenia-spectrum psychosis …
Researchers looked at how people with schizophrenia process information. They found no evidence for a general flaw in how the brain predicts…
DORAs show strongest evidence for insomnia while sedating antidepressants vary in antidepressant activity and side effects
Sedating Antidepressants and DORAs Show Different Benefits for Depression and Insomnia
This narrative review examines sedating antidepressants and dual orexin receptor antagonists (DORAs) for patients with major depressive diso…
New research highlights how different sedating antidepressants and DORAs offer varying levels of support for patients with depression and in…
Theta binaural beat therapy reduces pain scores in adults with a moderate effect size
Theta Binaural Beats May Reduce Pain and Anxiety Levels
This meta-analysis of 630 adults found that theta binaural beat therapy (4-8 Hz) resulted in a reduction in pain compared with controls (SMD…
A review of research suggests that listening to specific binaural beats may help reduce pain and anxiety in adults.
Ketogenic diets and intermittent fasting may improve weight, insulin sensitivity, and hepatic steatosis in MASLD
Ketogenic diets and fasting may improve liver health in patients
This narrative review examines the impact of ketogenic dietary interventions and intermittent fasting on patients with metabolic dysfunction…
New research suggests that ketogenic diets and intermittent fasting can help manage weight and liver fat in people with metabolic liver dise…