Pimavanserin adjunctive therapy shows small statistically significant reductions in PANSS scores below clinically meaningful thresholds for schizophrenia
Review finds pimavanserin offers little for schizophrenia negative symptoms
This systematic review and meta-analysis evaluated adjunctive pimavanserin in 1676 randomized participants with schizophrenia. The analysis …
A major review of 1,676 adults with schizophrenia found adding pimavanserin did not meaningfully improve negative symptoms, despite small st…
First case report links zonisamide to homicidal ideation in epilepsy patient
First case report links zonisamide to homicidal thoughts in an epilepsy patient
A case report and literature review describes a patient with epilepsy who developed homicidal ideation during zonisamide uptitration. Sympto…
A patient developed homicidal thoughts after taking zonisamide. This rare case highlights a serious psychiatric side effect of the drug that…
Emotion decoding deficits in older adults with depression may reflect impaired recognition, not hypersensitivity
Mixed signals on how depression affects emotional processing in older adults
This commentary critiques a meta-analysis on emotion recognition in older adults with major depressive disorder. It argues that negative sta…
A commentary suggests depression might impair how older adults decode emotions, but study selection heavily influences these conclusions.
Tourette syndrome involves multilevel dysfunction linking internal states to motor output via negative reinforcement
A new model explains how Tourette syndrome tics start and stop
This narrative review explores the pathophysiology of Tourette syndrome in patients with the condition. The authors synthesize evidence sugg…
This review explains how Tourette syndrome tics begin with internal urges and end with temporary relief, offering a clearer picture for pati…
Sleep problems affect 61% of adults with rheumatoid arthritis in WHO EMRO countries
Sleep troubles hit 60.9% of adults with rheumatoid arthritis in the Eastern Mediterranean
This systematic review and meta-analysis of 2,315 adults with rheumatoid arthritis in WHO EMRO countries found sleep-related problems are hi…
Sleep problems affect more than six out of ten adults with rheumatoid arthritis in the Eastern Mediterranean. Depression and pain are the st…
Meta-Analysis Reveals Shared Genetic Loci in Pediatric Nephrotic Syndrome and IgA Nephropathy
Genetic clues link immune cells to pediatric kidney disease risks
A meta-analysis of GWAS data identified nine genome-wide significant loci for pediatric steroid-sensitive nephrotic syndrome and 19 pleiotro…
A large genetic analysis connects specific immune cell pathways to pediatric kidney conditions, offering new targets for future treatments.
Solar-powered digital health systems improve uptime and data continuity in low-resource settings in Kenya and Ethiopia
Solar power boosts digital health uptime in Kenya and Ethiopia
This conceptual-empirical analysis review examines solar-powered digital health systems versus unreliable energy supply in healthcare facili…
Solar-powered digital health systems improve system uptime and data continuity in low-resource settings. This model offers a scalable way to…
Technology-enabled physical activity interventions show earlier adoption in non-clinical settings with clinical convergence later
New technology for physical activity shows promise but adoption varies by setting
This guideline summarizes a bibliometric trend analysis of 2,981 eligible studies indexed in Scopus and SportDiscus from 1953 to 2025. The a…
A major analysis of thousands of studies shows technology helps people move more, yet clinical settings often lag behind non-clinical ones i…
Swiss guidelines show broad consensus on ethical problems of coercion but note differences in normative goals and responsibility attribution
Swiss experts agree on one thing: coercion in mental health care is an ethical problem
This narrative review analyzes five documents from Swiss professionals and stakeholders regarding coercive measures in psychiatric disorders…
Five Swiss documents agree that forced treatment is ethically wrong. They also want to stop using it and focus on voluntary care instead.
Interventions reduce mental health symptoms in people affected by extreme weather events across multiple studies
Helpful actions reduce mental health problems after extreme weather events for many people
A comprehensive review of thirty-three studies reveals that targeted interventions significantly improve mental health outcomes for individu…
A review of thirty-three studies shows that specific actions help people feel better after disasters. These steps lower stress, sadness, and…
Systematic review links poor sleep quality and short duration to anxiety in older adults
Poor sleep quality and short sleep duration are linked to higher anxiety in older adults
This systematic review and meta-analysis examined the association between sleep disturbance and anxiety symptoms in 70,716 older adults aged…
A large review of over 70,000 older adults found that bad sleep and short sleep times are strongly connected to feeling anxious. People with…
Narrative review on atrial fibrillation and depression highlights bidirectional links and integrated care needs
Depression and heart rhythm problems may worsen each other
This narrative review synthesizes evidence on the bidirectional relationship between atrial fibrillation and depression. It suggests depress…
A new review suggests depression and atrial fibrillation can fuel each other, making it vital to screen for both conditions together.