Glucocorticoid use and rheumatoid arthritis significantly increase vertebral fracture risk in postmenopausal women
Several risk factors increase fracture risk for women with osteoporosis
This meta-analysis of 11 studies involving 7,605 participants identifies several risk factors for vertebral fractures in postmenopausal wome…
Women with rheumatoid arthritis or those using certain medications face a much higher risk of spine fractures.
TET2 functions as a tumor suppressor in myeloid malignancies and immunomodulator in solid tumors
TET2 protein acts as a key regulator in several diseases
This systematic review examines the role of TET2 across various conditions including hematological malignancies, solid tumors, and inflammat…
A key protein called TET2 helps control cell behavior and may play a major role in treating cancer and inflammatory conditions.
Anifrolumab shows higher odds for BICLA response compared to belimumab in systemic lupus erythematosus
New data helps doctors choose between two lupus treatments
This network meta-analysis of 8607 adult patients with SLE evaluated belimumab and anifrolumab plus standard of care. The analysis found tha…
Comparing two different biologics for lupus shows both are effective, but one may offer better results for specific symptoms.
JAK inhibitors show 81.7% treatment retention in adult patients with rheumatoid arthritis and interstitial lung disease
New data compares treatments for rheumatoid arthritis and lung disease
This network meta-analysis of 8,186 adult patients with rheumatoid arthritis and interstitial lung disease (RA-ILD) evaluated 14 pharmacolog…
A large review of over 8,000 patients helps identify which medications might best manage both joint pain and lung damage.
Crohn disease and ulcerative colitis causally raise ankylosing spondylitis risk
Crohn's disease and ulcerative colitis linked to joint inflammation
This Mendelian randomization meta-analysis found positive causal relationships between Crohn disease and ulcerative colitis and ankylosing s…
People with Crohn's disease or ulcerative colitis face a higher risk of developing ankylosing spondylitis, a form of inflammatory joint dise…
Tacrolimus significantly reduces urine protein compared to MMF, placebo, and intravenous cyclophosphamide
Tacrolimus shows promise for managing specific kidney markers in lupus nephritis
This meta-analysis of 1187 patients with lupus nephritis evaluates the efficacy and safety of tacrolimus. Findings indicate significant redu…
New data suggests tacrolimus can help lower protein levels in the urine and improve certain blood markers for patients with lupus nephritis.
Evaluating Biological DMARD Discontinuation versus Dose Reduction in Rheumatoid Arthritis Remission
Dose Reduction May Be Safer Than Stopping Biologic Drugs
Meta-analysis data indicates that complete withdrawal of bDMARDs significantly increases flare risk compared to dose reduction strategies.
Stopping biologic medications entirely may significantly increase flare risks for people with rheumatoid arthritis compared to simply reduci…
Minimally invasive fixation of thoracolumbar fractures in ankylosing spondylitis reduces operative time and blood loss
Minimally Invasive Surgery Shows Benefits for Ankylosing Spondylitis Fractures
This systematic review and meta-analysis of 443 patients with ankylosing spondylitis and thoracolumbar fractures found that minimally invasi…
Minimally invasive surgery may reduce blood loss and hospital stays for patients with ankylosing spondylitis who have suffered spinal fractu…
Black and Indigenous patients are under-represented in recent randomized controlled trials for systemic lupus erythematosus
Trial Data Shows Diverse Patients Underrepresented in Lupus Research
This meta-analysis of 63 studies from 2014 to 2024 identifies significant demographic imbalances in clinical trials for systemic lupus eryth…
Recent analysis shows that many ethnic and racial groups are underrepresented in clinical trials for systemic lupus erythematosus.
Multidisciplinary teams and bloodless medicine pathways may improve outcomes for acute gastrointestinal bleeding
New research looks at better ways to treat internal bleeding
This systematic review synthesizes evidence on organizational models, such as multidisciplinary team programs and transfusion-free pathways,…
Specialized team-based care and bloodless medicine pathways show promise for patients with serious gastrointestinal bleeding.
MSC therapy improves salivary flow in Sjögren's animal models, meta-analysis finds
Stem cells show promise for Sjögren's syndrome in early research
This meta-analysis of 25 preclinical studies in animal models of Sjögren's syndrome found that mesenchymal stem cells (MSCs), MSC-derived ex…
Early research using stem cells and their components shows potential to improve saliva flow and reduce inflammation in Sjögren's syndrome mo…
AML infiltration of bile duct identified as primary cause of acute pancreatitis in case report
Leukemia Cells Found as Cause of Severe Pancreatitis
This case report and literature review describes a 34-year-old man with acute pancreatitis and type 2 diabetes, where acute myeloid leukemia…
A rare case shows how a specific type of leukemia can infiltrate the pancreas and cause severe inflammation in patients with diabetes.