Case series identifies MSH2 variants in three families suspected of Lynch syndrome
Genetic study identifies Lynch syndrome variants in three families with colon cancer history
A case series of three families with suspected Lynch syndrome used whole-exome sequencing and immunohistochemistry to characterize MSH2 vari…
Genetic testing found new disease-causing variants in three families with colon cancer history, offering clues for precision screening and g…
Meta-analysis finds 3.58% stroke incidence after lung transplant, linked to 3-fold mortality increase
How often do strokes happen after a lung transplant? A new review finds out
A systematic review and meta-analysis of 33,175 adult lung transplant recipients from 17 studies found a pooled stroke incidence of 3.58%.
A stroke after a lung transplant triples the risk of death, a new review of 33,000 patients found, though the exact rate varies by hospital.
Retrospective study finds inverse association between NHHR and osteoporotic fracture risk
Study finds link between cholesterol ratio and lower fracture risk in hospital patients
A retrospective cross-sectional cohort study of 580 patients from a Chinese endocrinology department found a significant inverse association…
Higher cholesterol ratios linked to lower fracture risk in hospital patients, with highest levels showing 80% reduced odds of osteoporotic b…
Case report: Ravulizumab successfully treated COVID-19-triggered complement-mediated TMA in a kidney transplant recipient
Doctors report a single case where ravulizumab treated a rare blood disorder after COVID-19 in a kidney transplant patient
A case report describes a 75-year-old kidney transplant recipient who developed complement-mediated thrombotic microangiopathy (CM-TMA) trig…
A kidney transplant patient with COVID-19 improved after doctors treated a rare blood disorder with ravulizumab, showing age shouldn't block…
Phase III trial of AK111 for active ankylosing spondylitis completed with 510 patients
Can a new drug help people with painful spinal arthritis move more freely?
A Phase III, randomized, double-blind, placebo-controlled, multicenter study evaluated AK111 in 510 patients with active ankylosing spondyli…
A new drug called AK111 aims to help people with painful spinal arthritis move more freely by improving symptoms like pain and stiffness.
Phase 3 trial compares bimekizumab to placebo and ustekinumab for moderate to severe plaque psoriasis
Can a new psoriasis drug outperform an established treatment?
A phase 3 randomized controlled trial enrolled 567 adults with moderate to severe chronic plaque psoriasis to compare bimekizumab against pl…
A new psoriasis drug called bimekizumab is being tested against existing treatments in a major trial involving 567 adults to see if it helps…
Canakinumab shows efficacy in Japanese AOSD patients in Phase 3 open-label study
Could a monthly injection help control the painful flares of Adult-Onset Still's Disease?
A Phase 3, open-label, single-arm study evaluated canakinumab in 14 Japanese patients with Adult-Onset Still's Disease.
A monthly injection helped Japanese patients with Adult-Onset Still's Disease achieve meaningful symptom relief, supporting approval for thi…
Phase 3 Trial of Cenerimod for Lupus Nephritis: Efficacy and Safety Evaluation
Could a New Drug Help Improve Kidney Function in Lupus Patients?
A Phase 3 trial is assessing cenerimod's efficacy and safety in treating active lupus nephritis. The primary endpoint is complete renal resp…
A new trial tests whether adding cenerimod to regular treatment can improve kidney function in adults with active lupus nephritis over 76 we…
Phase 3 Trial: Anifrolumab Shows Promise in SLE with BICLA Response as Primary Outcome
Could a New Treatment Offer Hope for Patients with Lupus?
In a Phase 3 trial with 367 SLE patients, subcutaneous anifrolumab was tested against placebo. The primary endpoint is the BICLA response, b…
A new subcutaneous treatment is being tested to help adults with moderate to severe lupus who aren't responding well to standard care.