Pegylated interferon-alpha toxicity mechanisms and management in chronic hepatitis B patients
New Way to Handle Painful Side Effects of Hepatitis B Drug
This systematic review examined mechanisms and management of pegylated interferon-alpha toxicity in patients with chronic hepatitis B.
A powerful hepatitis B drug can cause severe flu-like symptoms and other painful reactions, but new strategies aim to manage these side effe…
Cord blood trans fatty acids and Gammaproteobacteria signatures associated with infant colic and excessive crying
A Clue in Cord Blood May Predict Which Babies Get Colic
This exploratory cohort study examined cord blood biomarkers in 405 infants born between 1999 and 2002 in the greater Boston area.
For the first time, scientists have found biological hints in a newborn's blood that may signal a risk for developing colic months later.
Antimicrobial stewardship bundle improved perioperative antibiotic protocol adherence in oncourology surgeries
A Simple Hospital Change Slashed Antibiotic Use Without Harming Patients
A retrospective observational study of 226 patients undergoing prostatectomy or nephrectomy found that implementing an antimicrobial steward…
A focused hospital program slashed antibiotic use by nearly a third while keeping patients safe from dangerous superbugs.
Liquid biopsy shows high sequencing success in high-risk localized prostate cancer feasibility study
Blood Tests Replace Biopsies for Prostate Cancer
A phase 2 neoadjuvant trial in 22 patients with high-risk localized prostate cancer found liquid-based genomic profiling achieved 100% seque…
A simple blood draw now replaces painful prostate biopsies, capturing the same genetic details doctors need to pick the best treatment.
PET-guided radiation dose escalation linked to improved event-free survival in prostate cancer recurrence
Can more targeted radiation help men whose prostate cancer returns after surgery?
In this randomized trial of 140 men with biochemical progression after prostatectomy, radiation therapy dose escalation guided by either [F]…
Using advanced PET scans to guide stronger radiation helped 87% of men with returning prostate cancer stay event-free after two years.
Phase II trial finds adding gemcitabine to cisplatin-radiotherapy does not improve 2-year disease-free survival in muscle-invasive bladder cancer
Adding gemcitabine to cisplatin did not improve disease-free survival in bladder cancer patients
A Phase II randomized trial in 69 patients with pT2-pT3N0M0 muscle-invasive bladder cancer found similar 2-year disease-free survival (58.3%…
Adding gemcitabine to cisplatin radiotherapy did not improve disease-free survival for bladder cancer patients, with similar two-year rates …
Review explores TRIM protein roles in HIV pathogenesis and potential therapeutic targets
Review explores how TRIM proteins might help fight advanced HIV infection
A systematic review examines the molecular mechanisms of TRIM proteins in advanced HIV infection.
TRIM proteins in the body help fight advanced HIV infection by blocking the virus through several different cellular pathways and breaking d…
Dutasteride-Tadalafil FDC Shows Superior Symptom Reduction in BPH Phase III Trial
Does taking two prostate drugs together work better than just one for symptom relief?
A phase III randomized trial in 619 BPH patients found a fixed-dose combination (FDC) of dutasteride 0.5 mg/tadalafil 5 mg significantly imp…
Men taking two prostate drugs together saw symptom relief twice as fast as single-drug therapy, though they faced more side effects.
Audit plus peer comparison improved documentation of tumour features and resection completeness in non-muscle-invasive bladder cancer surgery
Audit and feedback improved documentation of bladder cancer surgery details in a large trial
This cluster randomised controlled trial involved 14,915 patients undergoing transurethral resection of bladder tumour surgery across 201 si…
This large study examined whether adding peer comparison and education to standard audits changed how bladder cancer surgery was performed.
Targeted plus perilesional biopsy noninferior to combined biopsy for prostate cancer detection
Could a simpler prostate biopsy find dangerous cancers just as well?
A single-center RCT in 380 biopsy-naïve patients with a single unilateral suspicious MRI lesion found targeted plus perilesional biopsy (TPL…
A simpler prostate biopsy found dangerous cancers just as well as the standard method while causing less pain and bleeding for men with susp…
Prior HoLEP association with longer operative time and catheter duration in subsequent RARP
Does prior prostate surgery make your next operation harder or riskier?
This systematic review and meta-analysis of three retrospective studies compared men undergoing robot-assisted radical prostatectomy (RARP) …
Prior prostate surgery makes the next operation take longer and requires more rebuilding, but cancer removal and recovery remain just as eff…
ThuFLEP shows early safety, high catheter-free rate in small BPH cohort
Can a new laser procedure help men with enlarged prostates get home faster?
A prospective cohort study of 32 men with BPH undergoing ThuFLEP found no Clavien-Dindo grade ≥3 complications and an 87.5% catheter-free ra…
A new laser prostate surgery helped 88% of men go home without a catheter the next day and eliminated all catheters within two weeks.