N/A
Completed N=34
Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training
Source: ClinicalTrials.gov NCT01083901 ↗Enrolled (actual)
34
Serious AEs
0.0%
Results posted
Mar 2013
Primary outcomePrimary: Change in Total Body Fat-free Mass — 1.5; 2.3; 0.7 kg — p=0.38
Summary
The purpose of this study is to determine if taking the pain reliever acetaminophen (ACET) interferes with some of the benefits of weight lifting on muscles and bone density in older men.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Total Body Fat-free Mass |
1.5; 2.3; 0.7 | 0.38 |
| SECONDARY Change in Total Body Fat Mass |
-1.5; -1.4; -0.2 | 0.23 |
| SECONDARY Changes in Upper Body Strength. |
19.5; 35.2; 26.5 | 0.30 |
| SECONDARY Change in Lower Body Strength |
33.1; 40.8; 18.0 | 0.37 |
Eligibility Criteria
Inclusion Criteria
- average use of acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) [including aspirin] less than 3 days per month
- not currently engaged in moderate-to-vigorous weight-lifting exercise
- non-smoker
- willing to participate in a supervised exercise program for 9 months
Exclusion Criteria
- relative or absolute contraindications to regular use of acetaminophen or NSAIDs including known allergy or intolerance to either drug,history of peptic ulcer or GI bleeding, anemia, asthma with bronchospasm induced by aspirin or other NSAIDS, moderate or severe renal impairment, known hepatobiliary disease
- contraindications to exercise testing and training including congestive heart failure class III or IV, uncontrolled hypertension and unstable cardiovascular disease
- thyroid dysfunction
- orthopedic problems that limit the ability to perform vigorous exercise or increase the likelihood of the use of pain medications
- drugs known to alter bone metabolism
- allergy to lidocaine
- diabetes mellitus requiring pharmacologic therapy
Data sourced from ClinicalTrials.gov (NCT01083901). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.