N/A N=201 Randomized Single-blind Treatment

Depression Outpatient Cardiology Screening Study

Depression · Coronary Heart Disease

Bottom Line

View on ClinicalTrials.gov: NCT01552889 ↗

Enrolled (actual)

201

Serious AEs

0.0%

Results posted

Apr 2017

Primary outcome: Primary: Beck Depression Inventory 2 — 17.4; 15.9 units on a scale

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Collaborative Care (Behavioral)
Age: Adult, Older Adult · 21+ yrs
Sex: All
Sponsor: Washington University School of Medicine
Primary completion: Jul 2016

Outcome Measures

Outcome	Result	p-value
PRIMARY Beck Depression Inventory 2	17.4; 15.9	—
SECONDARY Treatment Satisfaction Scale.	3.3; 4.0	—
SECONDARY PROMIS Physical Functioning Scale 10a Short Form	39.6; 39.2	—

Summary

This study compares the effects of depression screening and case management to usual care in cardiology outpatients with documented evidence of coronary heart disease. Despite strong evidence that depression is a risk factor for cardiac events, there is insufficient evidence to support the use of depression screening in cardiac patients.

Eligibility Criteria

Inclusion Criteria

recent history of Acute Coronary Syndrome or other cardiac event or documented heart disease
score of 10 or higher on the Patient Health Questionnaire

Exclusion Criteria

suicidal ideation or behavior
cognitive impairment or inability to read or speak English
schizophrenia, bipolar disorder
active substance abuse or alcoholism
severe valvular disease, severe congestive heart failure, malignancy
physical limitations that would interfere with participation in the study
medical contraindications to the use of available antidepressants
participation in a competing research protocol
physician or patient refusal

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01552889). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.