N/A
N=123
Contingency Management of Alcohol Abuse in the Severely Mentally ILL
Alcohol Abuse · Schizophrenia · Bipolar Disorder · Major Depressive Disorder
Bottom Line
View on ClinicalTrials.gov: NCT01567943 ↗Enrolled (actual)
123
Serious AEs
0.0%
Results posted
Jan 2017
Primary outcome: Primary: Alcohol Use as Assessed by Ethyl Glucuronide Detection in Urine — 408.86; 734.79 EtG Value (nanograms per milileter)
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Contingency Management (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Washington
- Primary completion
- Feb 2015
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Alcohol Use as Assessed by Ethyl Glucuronide Detection in Urine |
408.86; 734.79 | — |
| SECONDARY Change in Intensive Outpatient Substance Abuse Treatment Attendance |
57; 53 | — |
| SECONDARY Self Report Drug Use |
— | — |
| SECONDARY Other Drug Use as Measured by Urinalysis |
— | — |
| SECONDARY Community Outcomes |
— | — |
| SECONDARY Psychiatric Symptomology |
— | — |
Summary
The investigators will evaluate the efficacy of a comprehensive 12-week contingency management intervention for treating alcohol dependence for persons with severe mental illness who are seen within the context of a community mental health center setting. The primary contingency will be submission of alcohol-free urines. Additional reinforcers will be provided for intensive outpatient addiction treatment attendance. Reinforcers will be vouchers or actual items useful for day-to-day living. Participants will be 120 adults diagnosed with alcohol dependance and severe mental illness.
Eligibility Criteria
Inclusion Criteria
- Currently receiving psychiatric [AND intensive outpatient addiction treatment] at Community Psychiatric Clinic (CPC).
- Aged 18 to 65 years.
- Ability to understand written and spoken English language.
- DSM-IV diagnosis of alcohol dependence as assessed by the MINI psychiatric interview.
- Diagnosis of current serious mental illness: schizophrenia, schizoaffective disorders, bipolar disorder I or II, or recurring major depressive disorders as assessed by the MINI psychiatric interview.
- Alcohol use in the month prior to study entry: self-reported alcohol use of 5 days or more during the 30 days prior to study entry (5 drinking days/month is selected based on previous research reporting alcohol use in 18% of days assessed in a sample of psychiatric outpatients with co-occurring SUDs & SMI).120
- A CPC treating clinician must affirm the potential participant is safe to participate in the study.
Exclusion Criteria
- A significant risk of dangerous alcohol withdrawal: a history of alcohol detoxification or seizure in the last 12 months AND participant or clinician concern that abstinence will induce dangerous alcohol withdrawal.
- DSM-IV diagnosis of current (last year) drug dependence as assessed by the MINI interview.
- Any medical/psychiatric condition, or severity of that condition, that in the opinion of the PI, would compromise safe study participation.
- Chart defined organic brain disorder or dementia.
- Inability to provide informed consent as measured by the University of California San Diego Brief Assessment of Capacity to Consent (UBACC), a tool designed to screen for ability to provide informed consent for research. If indicated by the UBACC screening process, the more comprehensive MacCAT-CR will be used.
Data sourced from ClinicalTrials.gov (NCT01567943). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.