N/A
N=93
Transdiagnostic Psychotherapy for Veterans With Mood and Anxiety Disorders
Major Depressive Disorder · Persistent Depressive Disorder · Posttraumatic Stress Disorder · Panic Disorder · Social Phobia
Bottom Line
View on ClinicalTrials.gov: NCT01947647 ↗Enrolled (actual)
93
Serious AEs
0.0%
Results posted
Aug 2019
Primary outcome: Primary: DASS-Depression — 3.93; 5.91; 4.51; 6.01 score on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Transdiagnostic Behavior Therapy (Behavioral); Behavioral Activation Therapy (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- VA Office of Research and Development
- Primary completion
- Jun 2018
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY DASS-Depression |
3.93; 5.91; 4.51; 6.01 | — |
| PRIMARY DASS-Anxiety |
4.05; 3.86; 4.14; 4.15 | — |
| PRIMARY DASS-Stress |
5.94; 5.00; 6.29; 5.93 | — |
| PRIMARY STICSA-Cognitive |
18.10; 16.90; 18.05; 17.85 | — |
| PRIMARY STICSA-Somatic |
16.57; 16; 16.81; 16.96 | — |
| PRIMARY IIRS |
33.13; 33.84; 32.85; 29.77 | — |
Summary
Cognitive behavioral therapy (CBT) is a brief, efficient, and effective psychotherapy for individuals with depressive and anxiety disorders. However, CBT is largely underutilized within Veteran Affairs Medical Centers (VAMCs) due to the cost and burden of trainings necessary to deliver the large number of CBT protocols. Transdiagnostic CBT, in contrast, is specifically designed to address numerous distinct disorders within a single protocol. This transdiagnostic approach has the potential to dramatically improve the accessibility of CBT within VAMCs and therefore improve clinical outcomes of Veterans. The proposed research seeks to evaluate the efficacy of a transdiagnostic CBT by assessing clinical outcomes and quality of life in VAMC patients with depressive and anxiety disorders throughout the course of treatment and in comparison to an existing evidence-based psychotherapy, behavioral activation treatment.
Eligibility Criteria
Inclusion Criteria
Inclusion criteria involve:
- participants must be clearly competent to provide informed consent for research participation;
- participants must meet DSM diagnostic criteria for a principal diagnosis of a depressive/anxiety disorder (Panic Disorder, PTSD, Social Anxiety Disorder, Obsessive-Compulsive Disorder (OCD), Generalized Anxiety Disorder (GAD), specific phobia, major depressive disorder, or persistent depressive disorder); and
- participants must be 18 - 80 years old.
Exclusion Criteria
Exclusion criteria involve:
- recent history (< 2 months) of psychiatric hospitalization or a suicide attempt as documented in their medical record,
- current diagnosis of substance dependence or abuse on the structured clinical interview,
- acute, severe illness or medical condition that likely will require hospitalization and/or otherwise interfere with study procedures as documented in their medical record (e.g., active chemotherapy/radiation treatment for cancer, kidney dialysis, oxygen therapy for chronic obstructive pulmonary disease),
- recent start of new psychiatric medication (< 4 weeks),
- diagnosis of traumatic brain injury (TBI) in their medical record and/or endorsement of screener questionnaire regarding the symptoms of TBI modified from the Post-Deployment Health Assessment employed by the Department of Defense, or
- diagnosis of schizophrenia, psychotic symptoms, personality disorder, and/or bipolar disorder. VAMC patients excluded due to these factors will be reconsidered for participation once the condition related to their exclusion is resolved or stabilized. Together, these inclusion/exclusion criteria should allow the vast majority of interested VAMC patients with depressive/anxiety disorders to be eligible to participate. Ineligible VAMC patients will be referred for non-study-related treatments within mental health at the RHJ VAMC.
Data sourced from ClinicalTrials.gov (NCT01947647). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.