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Home › Conditions › Panic Disorder

Panic Disorder

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Panic Disorder

25 trials tracked for Panic Disorder: 12 in phase 3 or 4 and 3 with published results. The most-cited published study has 246 citations.

25Trials tracked
12Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 10 Phase 3 2 Phase 2 4 Other / NA 9
  1. Phase 4 Primary Care Intervention Strategy for Anxiety Disorders Completed · 246 cited
  2. Phase 3 Comparison of Psychotherapy Programs to Treat Panic Disorder Completed · 83 cited
  3. Phase 4 Ziprasidone in Bipolar Disorder With Comorbid Lifetime Panic or Generalized Anxiety Disorder(GAD) Completed · 22 cited
  4. Phase 4 Quetiapine SR and Divalproex Sodium ER in the Treatment of Anxiety in Bipolar Disorder With Panic Disorder and/or GAD Completed
  5. Phase 4 The Role of Orexin in Human Panic Disorder Completed
  6. Phase 4 A Collaborative Care Program to Improve Treatment of Depression and Anxiety Disorders in Cardiac Patients Completed
Show 19 more trials
  1. Phase 4 Efficacy of Aerobic Exercise Added to Alprazolam in Panic Disorder Treatment Completed
  2. Phase 4 A Study of Quetiapine SR (Seroquel SR) to Treat SSRI-Resistant, Comorbid Panic Disorder Patients Completed
  3. Phase 4 The Efficacy and Tolerability of Duloxetine for the Treatment of Panic Disorder Completed
  4. Phase 4 A Study Of Sertraline Compared With Paroxetine In The Treatment Of Panic Disorder Completed
  5. Phase 4 Trial to Compare Time to Response in the Symptoms of Anxiety to Concomitant Treatment With Niravam™ and an SSRI or SNRI to Treatment With an SSRI or SNRI Alone in Subjects With Generalized Anxiety Disorder or Panic Disorder Completed
  6. Phase 3 Therapies for Treatment-Resistant Panic Disorder Symptoms Completed
  7. Phase 2 Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Panic Disorder With Comorbid Major Depression Completed
  8. Phase 2 Levetiracetam for the Treatment of Alcohol Dependence and Anxiety Completed
  9. Phase 2 Safety and Efficacy of HB-1 for Panic Disorder Completed
  10. Phase 2 Exposure, D-Cycloserine Enhancement, and Genetic Modulators in Panic Disorder Completed
  11. N/A Transdiagnostic Psychotherapy for Veterans With Mood and Anxiety Disorders Completed
  12. N/A Special Investigation Of Long Term Use Of Sertraline. Completed
  13. N/A Using the Canary Breathing System for Panic Disorder Patients Completed
  14. N/A Drug Use Investigation of Jzoloft. Completed
  15. N/A Parent-based Treatment for Youth With Anxiety and Obsessive-compulsive Disorder Completed
  16. N/A Neurofeedback Enhanced Cognitive Reappraisal Training Completed
  17. N/A LUCHAR - Latinos Using Counseling for Help With Asthma and Anxiety Reduction Completed
  18. N/A Special Investigation Of J Zoloft For Panic Disorder Patients Completed
  19. N/A Internet-based Self-help Treatment for Panic Disorder: Two Ways of Complementary Psychological Support Completed

Showing the 25 most-cited and recently-updated of 25 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Panic Disorder: what the trials found

Pharmacological management of Panic Disorder includes several agents with demonstrated efficacy. Quetiapine SR showed significant improvements in CGI-21 anxiety scores, Patient Global Improvement Scale (PGI-21) for anxiety symptoms, and Hamilton Anxiety Scale (HAM-A) scores (p < 0.05) 4. Quetiapine XR was associated with reductions in Panic Disorder Severity Scale (PDSS) scores, as well as improvements in HAM-D, HAM-A, and Pittsburgh Sleep Quality Index (PSQI) scores 5. Sertraline demonstrated significant mean reductions in Hamilton Anxiety Rating Scale (HAM-A) scores and substantial improvements in Panic and Agoraphobia Scale (PAS) total scores, with a high percentage of participants achieving clinical improvement on the CGI scale 8.

Other pharmacological interventions include Alprazolam, which resulted in significant reductions in HAM-A scores (p < 0.001) 10. Clonazepam showed significant improvements in panic disorder symptoms during Phase 1 of treatment (Week 0 to Week 6), though subsequent phases did not reach statistical significance 12. Other interventions included Ziprasidone 2, Duloxetine 7, and suvorexant 3, along with general psychotropic medication optimization 1.

Non-pharmacological approaches provide mixed results. Collaborative care significantly improved mental health-related quality of life and reduced depression symptoms, but did not produce a statistically significant change in anxiety symptoms 6. Cognitive behavioral therapy (CBT) was evaluated but did not show a statistically significant reduction in Panic Disorder Severity Scale scores 11.

Recent results — preliminary, needs further review

  • Functional magnetic resonance imaging (fMRI) with Veritable-NF is currently being investigated 17.

For the clinician treating this condition

  • Quetiapine (both SR and XR formulations) and Sertraline are supported by evidence for reducing anxiety scores and improving overall panic symptoms.
  • Alprazolam provides significant reduction in Hamilton Anxiety Rating Scale scores, while Clonazepam shows efficacy specifically in the initial phase of treatment.
  • Collaborative care is effective for improving quality of life and depression but may not significantly impact primary anxiety symptoms compared to pharmacological interventions.

AI synthesis of 12 cited trials, updated Jun 25, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Maximal voluntary breath-holding time identifies shorter interoceptive tolerance in patients with panic disorder
Psychiatry Meta-analysis
Maximal voluntary breath-holding time identifies shorter interoceptive tolerance in patients with panic disorder Breath Holding Time May Help Identify Panic Disorder Symptoms
This meta-analysis of 1263 participants indicates that individuals with anxiety disorders exhibit shorter maximal voluntary breath-holding t…
A large review shows that people with panic disorder can hold their breath for shorter periods than healthy individuals, potentially marking…
Sep 1, 2026
Intolerance of uncertainty and worry show robust associations with multiple anxiety disorders
Psychiatry Meta-analysis
Intolerance of uncertainty and worry show robust associations with multiple anxiety disorders Understanding how the fear of uncertainty drives constant worrying and anxiety
This meta-analysis of 138 independent samples (28,693 individuals) identified a structural model where intolerance of uncertainty (IU) predi…
New research shows that struggling with uncertain outcomes often leads to constant worrying, which is a major driver of many different anxie…
Aug 9, 2026
Transdiagnostic behavior therapy shows comparable efficacy to disorder-specific therapies in veterans with depression, PTSD, and panic disorder
Psychiatry RCT
Transdiagnostic behavior therapy shows comparable efficacy to disorder-specific therapies in veterans with depression, PTSD, and panic disorder Veterans with depression or anxiety found similar results using transdiagnostic behavior therapy compared to disorder specific treatments
This randomized controlled trial in 304 veterans compared transdiagnostic behavior therapy to disorder-specific therapies for major depressi…
A study of 304 veterans showed that transdiagnostic behavior therapy worked just as well as standard disorder specific treatments. Patients …
May 8, 2026
Meta-analysis finds large symptom reductions with Detached Mindfulness for OCD and panic disorder
Psychiatry Meta-analysis
Meta-analysis finds large symptom reductions with Detached Mindfulness for OCD and panic disorder Could a new mindfulness approach help reduce symptoms of OCD and panic disorder?
This systematic review and meta-analysis synthesized evidence on Detached Mindfulness as a stand-alone intervention for obsessive–compulsive…
A new mindfulness approach called Detached Mindfulness helped reduce symptoms of OCD and panic disorder while also lowering feelings of sadn…
Frontiers Apr 16, 2026
Panic disorder symptoms decreased during guideline-based pharmacotherapy in small observational cohort
Psychiatry Cohort
Panic disorder symptoms decreased during guideline-based pharmacotherapy in small observational cohort Panic disorder symptoms improved during six months of standard medication treatment
A retrospective observational cohort study of 41 adults with panic disorder found that Panic Disorder Severity Scale total and agoraphobia s…
Adults with panic disorder saw their symptoms and fear of crowds drop significantly after six months of standard medication treatment.
Frontiers Apr 3, 2026

Questions about Panic Disorder

Can detached mindfulness reduce panic disorder symptoms when used as a stand-alone treatment?

Detached mindfulness can reduce panic disorder symptoms when used alone, but current evidence comes from only one small clinical trial, so the results are not yet fully settled.

Full answer →