30 closest matches · ranked by relevance
Nonalcoholic Fatty Liver Disease (NAFLD)
Primary: Change in Intrahepatic Lipid Content Between Baseline and 6 Months as Measured by 1H-magnetic Resonance Spectroscopy (1H-MRS). Endpoints Were Assessed at Baseline and 6…
Non-alcoholic Fatty Liver Disease
Primary: Hepatic Insulin Sensitivity Index (HISI) — 0.8; 1.4 [10000/(μmol/min)x(mU/L)] — p=<0.019
Type 2 Diabetes · Obesity
Primary: Insulin Sensitivity — 8 m value — p=<0.05
Obesity · Fatty Liver, Nonalcoholic
Primary: Insulin-stimulated Glucose Uptake — 5.9; 5.9 mg/kg/minute
Hepatic Steatosis · Polycystic Ovarian Syndrome · Obesity
Primary: Hepatic Glucose Release — 1.85; 1.46; 1.54; 1.88 mg/kg/min
Hepatic Steatosis
Primary: Hepatic Triglyceride (%) — 15.9; 14.8 Fat/Fat+Water (%) — p=0.42
Hepatic Steatosis · Bariatric Surgery Candidate · Adolescent Obesity
Primary: Change in Percentage of Liver Fat Per MRI — -13.93 percentage of liver fat
Non-alcoholic Fatty Liver Disease
Primary: Percent Change From Baseline in Hepatic Fat — -35.73; -18.04; 8.63 Percent change — p=<0.001
Human Immunodeficiency Virus (HIV) · Nonalcoholic Fatty Liver Disease (NAFLD) · Nonalcoholic Steatohepatitis (NASH)
Primary: Change in Liver Fat as Measured by 1-H Magnetic Resonance Spectroscopy — -4.7; 0.0 percent (hepatic fat fraction)
Polycystic Ovarian Syndrome · Obesity · Hepatic Steatosis
Primary: Hepatic Fat Fraction — 8.35 Percent
Lipid Metabolism, Inborn Errors · Hyperlipidemias · Metabolic Diseases
Primary: Change From Baseline in Liver Triglyceride (TG) Content As Measured by Magnetic Resonance Spectroscopy (MRS) — 0.2; 1.2; 6.4; 0.8 percentage of total liver content…
Nonalcoholic Fatty Liver · Nonalcoholic Steatohepatitis
Primary: Absolute Change in Intrahepatic Lipid Content, by 1H-MRS — -6.6; 3.6 Mean absolute percentage change
NASH - Nonalcoholic Steatohepatitis; NAFLD - Nonalcoholic Fatty Liver Disease
Primary: Percent Change in Liver Fat Between Baseline and 12 Weeks Post-surgery — -16.4 percent change
Fatty Liver
Primary: Hepatic Fatty Acid Oxidation
NAFLD · Nonalcoholic Fatty Liver · NASH - Nonalcoholic Steatohepatitis
Primary: Intrahepatic Lipid Content (IHL, Percent Liver Fat) — 3.9 absolute change in percentage liver fat — p=0.4
NAFLD
Primary: Change in Hepatic Fat — -10.046; 3.083; -4.013 percentage — p=0.0572
Non-Alcoholic Fatty Liver Disease
Primary: Participants With Normalized Liver Enzyme Levels — 0; 0 Participants
Non-Alcoholic Fatty Liver Disease · Insulin Resistance · High Intensity Interval Training
Primary: Intrahepatic Triglyceride (IHTG) — 5.26; 8.97 percentage of IHTG — p=0.363
Nonalcoholic Steatohepatitis
Primary: Liver Histology (Kleiner's et al Criteria, Hepatology 2005) — 7; 13; 24 Participants
Fatty Liver, Nonalcoholic · Diabetes Mellitus, Type 2
Primary: Action on Suspected Advanced Liver Fibrosis — 55; 4 Participants
Obese Patients With Non-alcoholic Steatohepatitis (NASH)
Primary: Change From Baseline in Alanine Aminotransferase (ALT) at Week 12 — -22.06; -30.41; -8.77 Units per Liter (U/L) — p=0.075
Non-Alcoholic Steatohepatitis (NASH)
Primary: Percentage of Responders With Disappearance of Steatohepatitis Without Worsening of Fibrosis (ie, Participants no Longer Meeting the Criteria for Steatohepatitis) — 21…
Hepatitis
Primary: Number of Patients With Improvement in Liver Histology — 12 participants
Non-alcoholic Fatty Liver Disease
Primary: Liver Fat Content — 8.38; 7.72; 8.50; 7.29 percentage of liver fat content — p=0.94
Fatty Liver
Primary: Number of Participants With Sustained Reduction in Alanine Aminotransferase (ALT) to Either 50% of Baseline Value or < 40 IU/L — 9; 15; 10 participants — p=0.26
Nonalcoholic Steatohepatitis · Nonalcoholic Fatty Liver Disease · Type 2 Diabetes Mellitus
Primary: Liver Histology (Using Kleiner et al Criteria, Hepatology 2005) — 9; 29 Participants
Hyperlipidemia
Primary: Absolute Change From Baseline in Percent Hepatic Fat — 0.03; 4.72 Percent of Hepatic Fat — p=<0.001
Fatty Liver
Primary: Number of Participants With Improvement of >= 2 Points in NAFLD Activity Score (NAS) — 8; 9 Participants
Non-Alcoholic Fatty Liver Disease (NAFLD)
Primary: Percent Change From Baseline in Whole Liver Proton Density Fat Fraction (PDFF) at Day 42 — 8.14; -40.01; -30.14; -40.13 percent change — p=0.0000
Healthy Volunteers
Primary: Percentage Change in Liver Fat — 1.9; 1.9 percentage of change — p=0.390