Fatty pancreas prevalence 30.5% and linked to higher pancreatitis, cancer risk
Fatty pancreas is linked to higher risk of pancreatic cancer
This meta-analysis of 124 studies including 141,416 healthy or routine-examination participants found a fatty pancreas prevalence of 30.5%, …
A fatty pancreas is common and linked to a higher risk of serious conditions like pancreatic cancer and diabetes.
Pharmacist-led medication therapy management improves adherence and glycemic control in a patient with complex T2DM
Pharmacist-led care improves blood sugar for woman with long-term diabetes
This case report describes a single patient with type 2 diabetes who received pharmacist-led medication therapy management. The intervention…
A pharmacist-led review helped a woman with a 30-year history of Type 2 Diabetes significantly improve her medication adherence and blood su…
Citrus grandis Tomentosa flavonoids ameliorate hepatic steatosis and inflammatory responses in experimental MASLD models
Citrus flavonoids show potential in treating fatty liver disease
This scoping review synthesizes preclinical data on the efficacy of Citrus grandis Tomentosa (CGT) flavonoids in metabolic dysfunction-assoc…
New research suggests specific citrus compounds may reduce inflammation and fat buildup in the liver, offering a possible path for future tr…
Epigallocatechin-3-gallate shows positive therapeutic effects on various digestive system diseases in animal models
Green tea compound shows potential for several digestive diseases
This meta-analysis of 63 preclinical studies involving 738 animals indicates that Epigallocatechin-3-gallate (EGCG) has a positive therapeut…
A review of animal studies suggests a green tea compound could help treat various cancers and digestive conditions.
Systematic Review: Flavonoids from Traditional Chinese Medicine Show Promise for NAFLD
Flavonoids from Chinese medicine show promise for fatty liver disease
This systematic review examines flavonoids from traditional Chinese medicine for non-alcoholic fatty liver disease. The authors report that …
A systematic review suggests flavonoids from traditional Chinese medicine may improve liver health in humans and animals by reducing fat and…
Narrative review of palmitoleic acid links to metabolic health and fatty liver outcomes
Palmitoleic Acid Shows Mixed Links to Metabolic Health
This narrative review examines palmitoleic acid (POA) supplementation and food matrices regarding insulin resistance, fatty liver, and hyper…
Higher palmitoleic acid levels are tied to fatty liver and insulin resistance, but supplements show neutral effects.
Hepatic steatosis prevalence and impact in autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis
Fatty liver makes autoimmune hepatitis and PBC worse, but not PSC
This systematic review and meta-analysis of 19,898 patients with autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing c…
A large review found fatty liver is common in autoimmune liver diseases and makes outcomes worse for some patients, but not others.
Narrative review explores gut metabolites postbiotics obesity fatty liver and bone loss associations
Your Gut Microbes May Be Secretly Stealing Your Bone Strength
This narrative review examines the relationship between gut metabolites, postbiotics, and conditions including obesity, fatty liver, and bon…
A leaky gut can block calcium and vitamin D from reaching your bones, raising fracture risk.
Hepatic steatosis compromises APRI and FIB-4 accuracy for staging fibrosis in chronic hepatitis B patients
Does fatty liver ruin the accuracy of common blood tests for scarring in hepatitis B?
This retrospective cohort study evaluated treatment-naïve Han Chinese patients with chronic hepatitis B to assess how concurrent hepatic ste…
Fatty liver makes common blood tests for hepatitis B scarring nearly useless, dropping accuracy from 90% to under 50% and causing dangerous …
Research across Metabolic Dysfunction-Associated Steatotic Liver Disease
Related studies from across the Metabolic Dysfunction-Associated Steatotic Liver Disease family.
Efficacy of GLP-1 Receptor Agonists in Managing MASLD and MASH Clinical Outcomes
GLP-1 Drugs Linked to Less Liver Fat and Weight Loss
GLP-1 receptor agonists demonstrate significant reductions in liver fat, body weight, and transaminases in patients with MASLD or MASH.
A pooled analysis of 795 adults links GLP-1 drugs to less liver fat, lower liver enzymes, and modest weight loss in fatty liver disease.
mpMRI markers of liver disease are associated with lower health-related quality of life in MASH
Liver imaging markers linked to lower quality of life
This multinational real-world randomized controlled trial of 802 patients with suspected MASLD/MASH found that patients with MASH reported l…
New research shows that specific liver imaging markers are linked to lower quality of life and higher anxiety in patients with liver disease…
Short-chain fatty acids and intestinal macrophages modulate metabolism in metabolic syndrome and obesity
Short Chain Fatty Acids May Help Manage Metabolic Syndrome
This narrative review explores how short-chain fatty acids (SCFAs) like butyrate, acetate, and propionate influence intestinal macrophage im…
Short-chain fatty acids like butyrate may influence how the body handles inflammation and metabolism in people with obesity and insulin resi…
cGAS-STING pathway serves as a central axis for innate immune activation in MASLD and HCC
New research identifies a key immune pathway in fatty liver disease
This systematic review explores the role of the cGAS-STING pathway in metabolic dysfunction-associated steatotic liver disease and hepatocel…
A specific immune pathway called cGAS-STING may play a major role in how fatty liver disease progresses and leads to serious complications.
Hepatocyte senescence and SASP signaling contribute to inflammatory and fibrogenic remodeling in MASLD
Liver Cell Aging May Drive Fatty Liver Disease
This narrative review examines the role of hepatocyte senescence and SASP signaling in metabolic dysfunction-associated steatotic liver dise…
A new review suggests aging liver cells may help drive fatty liver disease, but human evidence is still limited.
Gut microbiota and probiotic-derived bioactive metabolites may offer therapeutic potential for metabolic disorders
Probiotics may offer new ways to manage metabolic health
This narrative review explores the role of gut microbiota- and probiotic-derived bioactive metabolites in managing obesity, type 2 diabetes,…
New research explores how specific molecules from probiotics could help manage conditions like obesity and type 2 diabetes.
m6A modification and METTL3 regulators influence lipid metabolism and progression of NAFLD and atherosclerosis
Scientists Link m6A Gene Changes to Obesity and Fatty Liver
This systematic review examines the role of m6A modification in lipid metabolism and its impact on obesity, NAFLD, and atherosclerosis. The …
A tiny chemical tag on RNA may help explain obesity, fatty liver, and hardening arteries, but the science is still early.
Higher histologic liver fibrosis stages correlate with increased risk of cirrhosis and hepatic decompensation
Liver Fibrosis Stages Linked to Higher Risk of Liver Failure
This meta-analysis of 32 studies evaluates the association between histologic liver fibrosis stages and clinical outcomes in patients with M…
Higher stages of liver fibrosis are linked to a significantly increased risk of liver failure and death in patients with fatty liver disease…
Mediterranean diet reduces BMI and triglycerides in patients with NAFLD and MASLD
Mediterranean diet shows modest benefits for fatty liver disease
This meta-analysis of 980 patients with NAFLD/MASLD found that a Mediterranean diet significantly reduced BMI (SMD -0.43) and triglycerides …
A Mediterranean diet can lower body mass index and triglycerides in people with fatty liver disease, though other metabolic markers stayed t…
Optimal ELF cutoffs identify significant fibrosis and cirrhosis in patients with MASLD
New test cutoffs help identify liver scarring in fatty liver disease
This meta-analysis of 37 cohorts from 34 studies evaluates the Enhanced Liver Fibrosis (ELF) Test for identifying fibrosis stages in MASLD. …
New data helps doctors use the ELF test to better identify different stages of liver scarring in patients with fatty liver disease.
Hepatic macrophage metabolic reprogramming and bidirectional signaling dictate the balance between liver injury and regeneration
New research identifies how liver cells communicate during chronic disease
This systematic review synthesizes the role of hepatic macrophages in metabolic dysfunction-associated steatotic liver disease, alcohol-asso…
New research reveals how specific immune cells in the liver switch between causing inflammation and repairing tissue damage.
Multidisciplinary interventions and Mediterranean diet adherence may modestly reduce BMI Z-score in pediatric obesity
Mediterranean diet and behavior changes help manage childhood obesity
This narrative review synthesizes evidence regarding the impact of Mediterranean diet (KIDMED) adherence and multidisciplinary interventions…
A Mediterranean-style diet combined with team-based care shows promise in reducing weight and improving health for children with obesity.
Questions about fatty liver
Are gut metabolites linked to obesity and conditions like fatty liver?
Yes, gut metabolites like short-chain fatty acids and bile acids are linked to obesity and fatty liver, with dysbiosis driving inflammation and metabolic dysfunction.
Full answer →Do quercetin and apigenin show promise for treating non-alcoholic fatty liver disease?
Yes, quercetin and apigenin show promise for NAFLD by reducing liver fat and inflammation, but most evidence comes from lab and animal studies; human trials are limited.
Full answer →Can the compound EGCG help treat digestive system diseases and fatty liver?
EGCG shows promise for treating fatty liver and other digestive diseases in animal and lab studies, but human trials are still needed to confirm its effectiveness.
Full answer →