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Fatty liver

Part of Metabolic Dysfunction-Associated Steatotic Liver Disease

9 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for fatty liver

25 trials tracked for fatty liver: 3 in phase 3 or 4 and 2 with published results. The most-cited published study has 88 citations.

25Trials tracked
3Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 1 Phase 3 2 Phase 2 13 Phase 1 1 Other / NA 8
  1. Phase 3 Liver and Fat Regulation in Overweight Adolescent Girls Completed · 88 cited
  2. Phase 4 Effect on Liver Fat and Metabolic Parameters When Switching a Protease Inhibitor or Efavirenz to Raltegravir Completed · 9 cited
  3. Phase 3 Treatment of Nonalcoholic Fatty Liver Disease in Children (TONIC) Completed
  4. Phase 2 A Preliminary Study to Evaluate Cysteamine Therapy in Human Subjects With Non-Alcoholic Steatohepatitis (NASH) Completed
  5. Phase 2 Growth Hormone Releasing Hormone Analog to Improve Nonalcoholic Fatty Liver Disease and Associated Cardiovascular Risk Completed
  6. Phase 2 Study of INT-747 in Patients With Diabetes and Presumed NAFLD Completed
Show 19 more trials
  1. Phase 2 Study of Gemcabene in Adults With FPLD Completed
  2. Phase 2 Safety, Tolerability, and Pharmacodynamics of IONIS-DGAT2Rx in Adult Patients With Type 2 Diabetes Completed
  3. Phase 2 A Study of Siliphos in Adults With Non-alcoholic Steatohepatitis (NASH) Completed
  4. Phase 2 Polyunsaturated Fatty Acids (PUFA) in Diabetic Fatty Liver Completed
  5. Phase 2 Study to Evaluate the Effect of GWP42003 on Liver Fat Levels in Participants With Fatty Liver Disease Completed
  6. Phase 2 Pioglitazone to Treat Fatty Liver in People With HIV Infection Completed
  7. Phase 2 A Clinical Trial to Evaluate the Efficacy and Safety of Two Aramchol Doses Versus Placebo in Patients With NASH Completed
  8. Phase 2 An Evaluation of the Safety and Efficacy of Nitazoxanide on Collagen Turnover in NASH Patients With Fibrosis Completed
  9. Phase 2 Treatment for Non-Alcoholic Fatty Liver With Different Doses of Vitamin E Completed
  10. Phase 2 Cholic Acid for Hepatic Steatosis in Lipodystrophy Completed
  11. Phase 1 Liver Positron Emission Tomography (PET) Study of Non Alcoholic Fatty Liver Disease Completed
  12. N/A Oral Amino Acid Nutrition to Improve Glucose Excursions in PCOS Completed
  13. N/A Conditionally Increased Output (CIO) Enhanced Ultrasound System Completed
  14. N/A The Effect of Growth Hormone Replacement on Liver Fat Completed
  15. N/A Evaluate Patients With Chronic Hepatitis by Three-dimensional Force-controlled Ultrasound Measurement Completed
  16. N/A Low Fat Vegan or American Heart Association Diets & Cardiovascular Risk in Obese 9-18 y.o. With Elevated Cholesterol Completed
  17. N/A Hepatic Mitochondrial Function in Youth Completed
  18. N/A Liver Fat Quantification by Magnetic Resonance Imaging (MRI) - Prediction of Postoperative Complications Completed
  19. N/A Post-Prandial Liver Glucose Metabolism in PCOS Completed

Showing the 25 most-cited and recently-updated of 25 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Fatty liver: what the trials found

Metformin treatment for 96 weeks resulted in a statistically significant reduction in the Nonalcoholic Fatty Liver Disease (NAFLD) score as determined by histologic feature scores from liver biopsies (p=0.02) 3. However, Metformin did not produce statistically significant changes in serum aspartate aminotransferase (AST) levels (p=0.32) or a sustained reduction in alanine aminotransferase (ALT) to 50% of baseline or <40 IU/L 3.

Other established interventions include Raltegravir 1 and Byetta 5Mcg Pen Injection 2.

Recent results — preliminary, needs further review

  • Tesamorelin showed a reduction in both NAFLD Activity Score and Fibrosis Score to zero 4.
  • A study using MRI imaging reported a -13.93% change in the percentage of liver fat 18.

For the clinician treating this condition

  • Metformin is associated with significant improvements in histologic NAFLD scores over 96 weeks, though it did not significantly impact ALT or AST levels.
  • Recent data suggests Tesamorelin and specific MRI-monitored interventions may impact liver fat and activity scores.

AI synthesis of 5 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Metabolic Dysfunction-Associated Steatotic Liver Disease

Related studies from across the Metabolic Dysfunction-Associated Steatotic Liver Disease family.

Dioscin shows therapeutic potential for various liver disorders including MASLD and hepatocellular carcinoma
Drug Pipeline Sys. Review
Dioscin shows therapeutic potential for various liver disorders including MASLD and hepatocellular carcinoma Plant Compound Dioscin Shows Promise For Liver Disease
This systematic review evaluates the hepatoprotective effects and pharmacokinetics of Dioscin in various liver diseases. The review conclude…
A plant compound called Dioscin may help protect the liver, but human evidence is still missing and high doses carry risks.
MASLD linked to 35% higher odds of HFpEF in pooled analysis of 899,629 patients
Cardiology Meta-analysis
MASLD linked to 35% higher odds of HFpEF in pooled analysis of 899,629 patients Liver Disease Linked to Higher Risk of Heart Failure
This meta-analysis of 3 studies (899,629 patients, 47,610 with MASLD) found that MASLD was associated with higher odds of clinically diagnos…
People with metabolic dysfunction-associated steatotic liver disease (MASLD) show a higher risk of developing heart failure with preserved e…
Ketogenic diets and intermittent fasting may improve weight, insulin sensitivity, and hepatic steatosis in MASLD
Psychiatry Sys. Review
Ketogenic diets and intermittent fasting may improve weight, insulin sensitivity, and hepatic steatosis in MASLD Ketogenic diets and fasting may improve liver health in patients
This narrative review examines the impact of ketogenic dietary interventions and intermittent fasting on patients with metabolic dysfunction…
New research suggests that ketogenic diets and intermittent fasting can help manage weight and liver fat in people with metabolic liver dise…
Viral hepatitis infections pose significantly higher risk for liver cancer than smoking-related lung cancer
Oncology Meta-analysis
Viral hepatitis infections pose significantly higher risk for liver cancer than smoking-related lung cancer Comparing the risks of liver cancer from hepatitis versus lung cancer from smoking
This meta-analysis of 86,097,714 participants analyzed the relative risks of liver cancer from various exposures compared to lung cancer fro…
New data shows that certain hepatitis viruses pose a much higher risk for liver cancer than smoking does for lung cancer.
Efficacy of High-Intensity Interval Training and Moderate-Intensity Continuous Training in MASLD
Gastroenterology Meta-analysis
Efficacy of High-Intensity Interval Training and Moderate-Intensity Continuous Training in MASLD Exercise Types Improve Liver Health in MASLD Patients
Meta-analysis confirms that both HIIT and MICT significantly improve body composition, cardiometabolic markers, and liver function in MASLD …
High-intensity interval training and moderate continuous exercise both help MASLD patients. They improve body composition, metabolism, and l…
rs2896019 G allele associated with 51% increased risk of MASLD susceptibility
Gastroenterology Meta-analysis
rs2896019 G allele associated with 51% increased risk of MASLD susceptibility Genetic variant linked to increased risk of fatty liver disease
This meta-analysis of 15028 adults identified the rs2896019 polymorphism (G allele) as a significant risk factor for MASLD. The study found …
A specific genetic marker may significantly increase the risk of developing and progressing to severe fatty liver disease.
Low fat-free mass metrics are associated with increased risk of weight-related metabolic complications
Diabetes & Endocrinology Meta-analysis
Low fat-free mass metrics are associated with increased risk of weight-related metabolic complications Low muscle mass increases risk of diabetes and heart disease
This meta-analysis of observational studies involving 138,935 adults with overweight or obesity found that low fat-free mass (FFM) metrics a…
New data shows that having less fat-free mass is linked to a higher risk of developing type 2 diabetes and heart disease in adults.
Telmisartan leads to modest fasting blood sugar reduction in patients with MASLD
Gastroenterology Meta-analysis
Telmisartan leads to modest fasting blood sugar reduction in patients with MASLD Telmisartan Shows Modest Effects on Blood Sugar in Liver Disease
This meta-analysis of 258 adults with MASLD found that telmisartan resulted in a modest reduction in fasting blood sugar of -2.78 mg/dL. Oth…
A review of clinical data suggests that the medication telmisartan may lower fasting blood sugar in adults with certain types of liver disea…
Clinical trials for MASLD show limited racial and ethnic diversity despite increasing Hispanic enrollment
Gastroenterology Meta-analysis
Clinical trials for MASLD show limited racial and ethnic diversity despite increasing Hispanic enrollment Clinical trials for fatty liver disease lack diversity
This meta-analysis of 91 randomized controlled trials evaluates racial and ethnic diversity in MASLD clinical trials. While Hispanic enrollm…
Most fatty liver disease trials underreport ethnicity, and Black patients are only 2.5% of participants, despite the disease's impact.
Fibrosis-informed markers provide a decision architecture for statin allocation in intermediate-risk MASLD patients
Rheumatology Guideline
Fibrosis-informed markers provide a decision architecture for statin allocation in intermediate-risk MASLD patients New guidelines help doctors choose statins for liver disease patients
This guideline proposes a decision-making framework for statin therapy in the intermediate-risk stratum for patients with MASLD. It utilizes…
Doctors now have a clearer way to decide who needs statin treatment when liver health and heart risk overlap.
AI, machine learning, and deep learning models facilitate multimodal diagnosis and prognosis in MASLD
Rheumatology Sys. Review
AI, machine learning, and deep learning models facilitate multimodal diagnosis and prognosis in MASLD Artificial intelligence helps identify and predict fatty liver disease
This scoping review synthesizes 73 studies regarding the role of AI, machine learning, and deep learning in diagnosing and predicting outcom…
New technology is helping doctors identify fatty liver disease and predict its progress by analyzing complex data and medical images.
Phytochemicals modulate miRNA-mediated regulatory networks to influence metabolic reprogramming and cancer-associated signaling
Diabetes & Endocrinology Sys. Review
Phytochemicals modulate miRNA-mediated regulatory networks to influence metabolic reprogramming and cancer-associated signaling Phytochemicals May Influence RNA Networks Linked to Chronic Diseases
This narrative review explores how phytochemicals interact with miRNA-mediated regulatory networks through transcriptional, epigenetic, and …
New research explores how plant-based compounds might influence genetic switches that play a role in cancer and metabolic disorders.

Questions about fatty liver

Are gut metabolites linked to obesity and conditions like fatty liver?

Yes, gut metabolites like short-chain fatty acids and bile acids are linked to obesity and fatty liver, with dysbiosis driving inflammation and metabolic dysfunction.

Full answer →
Do quercetin and apigenin show promise for treating non-alcoholic fatty liver disease?

Yes, quercetin and apigenin show promise for NAFLD by reducing liver fat and inflammation, but most evidence comes from lab and animal studies; human trials are limited.

Full answer →
Can the compound EGCG help treat digestive system diseases and fatty liver?

EGCG shows promise for treating fatty liver and other digestive diseases in animal and lab studies, but human trials are still needed to confirm its effectiveness.

Full answer →