N/A
N=34
Depression and Pain Perseverance Through Empowered Recovery Intervention
Pain · Depressive Symptoms · Frailty · Aging
Bottom Line
View on ClinicalTrials.gov: NCT04091347 ↗Enrolled (actual)
34
Serious AEs
0.0%
Results posted
Jun 2025
Primary outcome: Primary: Pain Intensity as Assessed by the Patient Reported Outcomes Measurement Information System (PROMIS) — 6.75; 7.29; 6.64; 7.00 score on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- DAPPER (Behavioral)
- Age
- Adult, Older Adult · 50+ yrs
- Sex
- Female
- Sponsor
- Johns Hopkins University
- Primary completion
- Nov 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pain Intensity as Assessed by the Patient Reported Outcomes Measurement Information System (PROMIS) |
6.75; 7.29; 6.64; 7.00 | — |
| PRIMARY Depressive Symptoms as Assessed by the Patient Health Questionnaire 9 (PHQ-9) |
12.25; 11.53; 8.36; 11.43 | — |
| SECONDARY Interleukin (IL)-6 in Saliva (pg/ml) |
7.97; 8.19; 5.12; 7.54 | — |
| SECONDARY Interleukin (IL)-8 in Saliva (pg/ml) |
1780.22; 2847.77; 1305.79; 1805.99 | — |
| SECONDARY Interleukin (IL)-1 Beta in Saliva (pg/ml) |
154.7; 564.35; 247.47; 347.73 | — |
| SECONDARY Tumor Necrosis Factor (TNF)-Alpha in Saliva (pg/ml) |
5.09; 7.66; 3.56; 4.68 | — |
Summary
African American women who are 50 years of age and older with depressive symptoms, pain and difficulty with mobility will participate in the DAPPER intervention study that includes 8 nurse visits in participants' homes to help participants with participants' pain and mood.
Eligibility Criteria
Inclusion Criteria
- Self-report pain >3 out of a 0 -10 scale that has lasted longer than 3 months and keeps subjects from doing at least one activity that subjects would like to do
- Self-Identify as African American/Black female
- Live in a community dwelling
- Score a 5 or higher on the PHQ-9 (depression measure) at least two times during a two week period (screening call and then at first data collection visit)
- Must be pre-frail (one or two criteria on frailty phenotype) or frail (three or more of the criteria on frailty phenotype)
- One ADL or IADL limitation
Exclusion Criteria
- Hospitalized > 3 times in the last year
- Participating in physical therapy
- Have a terminal diagnosis ( moderate intellectual impairment (5-7 errors) based on the Short Portable Mental Status Questionnaire (SPMSQ)
- Unable to speak or understand English
Data sourced from ClinicalTrials.gov (NCT04091347). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.