N/A N=3,923 Randomized Health Services Research

Effectiveness and Implementation of eScreening in Post 9/11 Transition Programs

Depression · Stress Disorders, Post-Traumatic · Suicide

Bottom Line

View on ClinicalTrials.gov: NCT04506164 ↗

Enrolled (actual)

3,923

Serious AEs

—

Results posted

Feb 2026

Primary outcome: Primary: Compare Rate of PTSD Screening During eScreening Implementation and Sustainment vs. Screening as Usual/Pre-implementation — 724; 1408; 893 Participants — p=<.001

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: eScreening (Other); Screening As Usual (Other)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: VA Office of Research and Development
Primary completion: Dec 2023

Outcome Measures

Outcome	Result	p-value
PRIMARY Compare Rate of PTSD Screening During eScreening Implementation and Sustainment vs. Screening as Usual/Pre-implementation	724; 1408; 893	<.001 sig
PRIMARY Compare Rate of Depression (PHQ-2) Screening During eScreening Implementation and Sustainment vs. Screening as Usual/Pre-implementation	744; 1433; 905	<.001 sig
PRIMARY Compare Rate of Alcohol Screening (AUDIT) During eScreening Implementation and Sustainment vs. Screening as Usual/Pre-implementation	761; 1494; 929	<.001 sig
PRIMARY Compare Rate of Suicide Screening (CSSRS) During eScreening Implementation and Sustainment vs. Screening as Usual/Pre-implementation	831; 1588; 989	<.001 sig
PRIMARY Time to PTSD Screening (PC-PTSD-5) Completion During eScreening Implementation and Sustainment vs. Screening as Usual/Pre-implementation	27.90; 27.94; 27.74	<.001 sig
PRIMARY Time to Depression (PHQ-2) Screening Completion During eScreening Implementation and Sustainment vs. Screening as Usual/Pre-implementation	27.83; 27.88; 27.70	<.001 sig
PRIMARY Time to Alcohol Screening (AUDIT) Completion During eScreening Implementation and Sustainment vs. Screening as Usual/Pre-implementation	27.78; 27.74; 27.56	<.001 sig
PRIMARY Time to Suicide Screening (CSSRS) Completion During eScreening Implementation and Sustainment vs. Screening as Usual/Pre-implementation	27.30; 27.30; 27.02	<.001 sig
PRIMARY Change in Rate of Referral to Mental Health Care Following Positive PTSD Screen (PC-PTSD-5) During eScreening Implementation and Sustainment vs. Screening as Usual/Pre-implementation.	31; 32; 34	.257
PRIMARY Change in Rate of Referral to Mental Health Care Following Positive Depression Screen (PHQ-2) During eScreening Implementation and Sustainment vs. Screening as Usual/Pre-implementation	31; 28; 27	.846
PRIMARY Change in Rate of Referral to Substance Use Treatment Following Positive Alcohol Screen (AUDIT) During eScreening Implementation and Sustainment vs. Screening as Usual/Pre-implementation	5; 10; 7	.450
SECONDARY PRISM Contextual Survey Instrument (PCSI)	3.8; 4.2; 3.9	.057

Summary

Electronic screening is effective for timely detection of, and intervention for, suicidal ideation and other mental health symptoms. The VA eScreening program is a patient self-report electronic screening system that has shown promise for the efficient and effective collection of mental and physical health information among Veterans. However, additional effectiveness and implementation research is warranted to evaluate the impact of eScreening within VHA. This study addresses questions of the impact of eScreening compared to screening as usual, while evaluating a multi-component implementation strategy (MCIS) for optimal enterprise rollout of eScreening in VA Transition Care Management clinics.

Eligibility Criteria

Inclusion Criteria

Staff inclusion criteria:

Direct or indirect involvement with implementation of eScreening at the site
Capable of informed consent

Exclusion Criteria

Staff exclusion criteria:

Not involved in or directly impacted by eScreening involvement at each site

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04506164). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.