N/A
Completed N=26,139
Using Electronically Derived Automated Reports of Appropriate Antibiotic Use to Inform Stewardship Interventions
Source: ClinicalTrials.gov NCT06027593 ↗Enrolled (actual)
26,139
Serious AEs
—
Results posted
Nov 2025
Primary outcomePrimary: Guideline-concordant Antibiotic Use for Adults With Pharyngitis — 1458; 2477 Participants
Summary
The main goal of this study is to use automated electronic reports to assess and improve guideline-concordant antibiotic use for:
1) adult inpatients with community-acquired pneumonia; 2) pediatric inpatients with community-acquired pneumonia; 3) adult outpatients with acute pharyngitis; and 4) pediatric outpatients with acute otitis media.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Guideline-concordant Antibiotic Use for Adults With Pharyngitis |
1458; 2477 | — |
| PRIMARY Guideline-concordant Antibiotic Use for Children With Acute Otitis Media |
6154; 6287 | — |
| PRIMARY Guideline-concordant Antibiotic Use for Adults With Community-acquired Pneumonia |
204; 242 | — |
| PRIMARY Guideline-concordant Antibiotic Use for Children With Community-acquired Pneumonia |
213; 308 | — |
| SECONDARY Guideline-concordant Antibiotic Choice for Adults Hospitalized With Community Acquired Pneumonia |
268; 302 | — |
| SECONDARY Guideline-concordant Antibiotic Duration for Adults Hospitalized With Community Acquired Pneumonia |
230; 261 | — |
| SECONDARY 30-day Community Acquired Pneumonia-related Outpatient Revisits (Emergency Department, Urgent Care, or Primary Care) in Adults |
0; 0 | — |
| SECONDARY 30-day Readmissions for Community Acquired Pneumonia in Adults |
13; 6 | — |
| SECONDARY Guideline-concordant Antibiotic Choice for Pediatric Community Acquired Pneumonia |
394; 362 | — |
| SECONDARY Guideline-concordant Antibiotic Duration for Pediatric Community Acquired Pneumonia |
221; 322 | — |
| SECONDARY 28-day Community Acquired Pneumonia-related Outpatient Revisits (Emergency Department, Urgent Care, or Primary Care) in Children |
13; 20 | — |
| SECONDARY 28-day Readmissions for Pediatric Community Acquired Pneumonia |
8; 14 | — |
| SECONDARY Guideline-concordant Decision to Prescribe Antibiotics for Adult Pharyngitis |
1464; 2492 | — |
| SECONDARY Guideline-concordant Antibiotic Choice Adult Pharyngitis |
27; 160 | — |
| SECONDARY Guideline-concordant Antibiotic Duration for Adult Pharyngitis |
31; 175 | — |
| SECONDARY 30-day Pharyngitis Outpatient Revisits (Emergency Department, Urgent Care, or Primary Care) in Adults |
291; 578 | — |
| SECONDARY 30-day Deep Neck Space Infection Admission |
0; 1 | — |
| SECONDARY Guideline-concordant Decision to Prescribe Antibiotics for Pediatric Acute Otitis Media |
9935; 8547 | — |
| SECONDARY Guideline-concordant Antibiotic Choice for Pediatric Acute Otitis Media |
7498; 6828 | — |
| SECONDARY Guideline-concordant Antibiotic Duration for Pediatric Acute Otitis Media |
7565; 7281 | — |
| SECONDARY 28-day Acute Otitis Media-related Outpatient Revisits (Emergency Department, Urgent Care, or Primary Care) |
891; 756 | — |
| SECONDARY 28-day Mastoiditis or Intracranial Infection Admissions |
0; 0 | — |
| SECONDARY Guideline-concordant Decision to Not Prescribe Antibiotics for Pediatric Acute Otitis Media |
284; 292 | — |
| SECONDARY Guideline-concordant Decision to Not Prescribe Antibiotics for Adult Pharyngitis |
1432; 2312 | — |
Eligibility Criteria
Patient Inclusion Criteria:
- Diagnosis of one of four conditions based on ICD-10 diagnostic codes.
Patient Exclusion Criteria:
- Presence of specific complex chronic conditions
- Use of immunocompromising medications
- Transfer from another health facility.
Clinician Inclusion Criteria:
- Prescribing clinicians (including attending physicians, fellows, residents, nurse practitioners, and physician assistants) at one of the participating outpatient practices or inpatient units.
- Age ≥ 18 years old
- Employed by one of the participating sites
Clinician Exclusion Criteria:
- Volunteers or other non-employee hospital staff
- Limited English proficiency
Data sourced from ClinicalTrials.gov (NCT06027593). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.