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Home › Conditions › pharyngitis

Pharyngitis

Subtypes of Pharyngitis

Tonsillitis 4 Sore throat 1

7 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for pharyngitis

6 trials tracked for pharyngitis: 4 in phase 3 or 4 and 2 with published results. The most-cited published study has 30 citations.

6Trials tracked
4Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 3 4 Other / NA 2
  1. Phase 3 A Study of Flurbiprofen 8.75 mg Lozenge in Patients With Pharyngitis Completed · 30 cited
  2. Phase 3 A Study of Flurbiprofen 8.75 mg Lozenge in Patient With Pharyngitis Completed · 27 cited
  3. Phase 3 Double-blind Trial to Investigate Efficacy and Tolerance of Ambroxol Lozenges 20 mg in Sore Throat Completed
  4. Phase 3 Testing The Effectiveness Of Celecoxib In Patients With Painful Sore Throat Completed
  5. N/A Effect of Intra-cuff Lidocaine and Tetracaine on Tracheal Tube-induced Emergence Phenomena Completed
  6. N/A Using Electronically Derived Automated Reports of Appropriate Antibiotic Use to Inform Stewardship Interventions Completed

Showing the 6 most-cited and recently-updated of 6 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Pharyngitis: what the trials found

Clinical trials have evaluated various interventions for the management of sore throat pain and difficulty swallowing in pharyngitis. Placebo groups demonstrated statistically significant improvements in both Time Weighted Sum of Pain Intensity Differences (SPID) over 24 hours [1, 2] and in Difficulty Swallowing Scale (DSS) scores during both the initial 2 hours [1, 2] and 24-hour periods 1.

Specific pharmacological interventions showed varying results. Ambroxol as a lozenge demonstrated a significant reduction in the Sum of Pain Intensity Difference (SPIDnorm) over the first 3 hours post-dose 3, though changes in absolute pain intensity scores on a 6-point scale were not statistically significant 3. Celecoxib demonstrated a significant reduction in SPID2 at 2 hours post-dose 4 and significant improvements in Pain Intensity Difference (PID) between 7 and 24 hours post-dose 4, while PID values within the first 6 hours did not reach statistical significance 4.

Recent results — preliminary, needs further review

  • A large quasi-experimental study was conducted to evaluate interventions for pharyngitis, though specific outcome data were not provided in the trial summary 5.

For the clinician treating this condition

  • Placebo administration was associated with significant reductions in both sore throat pain intensity and difficulty swallowing over 24 hours [1, 2].
  • Ambroxol lozenges significantly reduced normalized pain intensity differences within the first 3 hours of use 3.
  • Celecoxib showed significant efficacy in reducing pain intensity specifically at the 2-hour mark and during the 7-to-24-hour window post-dose 4.

AI synthesis of 4 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Perioperative intraoral sucralfate reduces postoperative pain and improves mucosal healing after tonsillectomy
Anesthesiology & Pain Medicine Meta-analysis
Perioperative intraoral sucralfate reduces postoperative pain and improves mucosal healing after tonsillectomy Sucralfate may reduce pain and speed healing after tonsillectomy
This meta-analysis of 13 studies indicates that perioperative intraoral sucralfate reduces postoperative throat pain, swallowing pain, and o…
A new analysis suggests that a medicine called sucralfate can help patients manage pain and heal faster after tonsillectomy surgery.
Oct 5, 2026
mHealth app-supported care pathway did not significantly reduce caregiver state anxiety in ENT surgery cases
Psychiatry RCT
mHealth app-supported care pathway did not significantly reduce caregiver state anxiety in ENT surgery cases Mobile app support shows mixed results for anxious surgery caregivers
This randomized controlled trial of 227 caregivers of children undergoing ENT surgery found no statistically significant difference in careg…
A new trial looks at whether a mobile app can lower anxiety for parents whose children are facing upcoming ear, nose, or throat surgeries.
Sep 9, 2026
Proposed methodology for developing a Core Outcome Set to standardize Traditional Chinese Medicine trials for pharyngitis
Rheumatology Meta-analysis
Proposed methodology for developing a Core Outcome Set to standardize Traditional Chinese Medicine trials for pharyngitis New plan to standardize how doctors measure traditional medicine results
This protocol outlines a four-phase process to develop a Core Outcome Set (COS) for clinical trials involving Traditional Chinese Medicine (…
A new framework aims to create a standard way to measure how well Traditional Chinese Medicine treats sore throats.
Frontiers Jul 19, 2026
Minimally invasive tonsillectomy improves operative efficiency over cold dissection in chronic tonsillitis
Orthopedics & Sports Medicine Meta-analysis
Minimally invasive tonsillectomy improves operative efficiency over cold dissection in chronic tonsillitis Minimally invasive tonsil surgery may be more efficient
A systematic review and meta-analysis of 16 RCTs involving 1528 patients found that minimally invasive tonsillar surgical techniques improve…
New analysis suggests minimally invasive tonsil surgery may be faster and more efficient than traditional cold dissection.
Frontiers Jun 7, 2026
Systematic review and meta-analysis suggests Lanqin Oral Liquid plus Western medicine improves pharyngitis outcomes versus Western medicine alone
Oncology Meta-analysis
Systematic review and meta-analysis suggests Lanqin Oral Liquid plus Western medicine improves pharyngitis outcomes versus Western medicine alone Combining Lanqin Oral Liquid with standard Western medicine treatment helps patients with sore throat heal faster and feel better
This systematic review and meta-analysis evaluated Lanqin Oral Liquid combined with Western medicine for pharyngitis compared to Western med…
A review of twelve studies found that adding Lanqin Oral Liquid to standard Western medicine helps patients with pharyngitis heal faster. Th…
Frontiers May 14, 2026
FDA Approves Children's Advil (ibuprofen) for Fever and Minor Aches in Children
Pediatrics FDA Approval
FDA Approves Children's Advil (ibuprofen) for Fever and Minor Aches in Children FDA approves Children's Advil for fever and pain relief in kids.
The FDA approved Children's Advil (ibuprofen) oral suspension for temporary fever reduction and relief of minor aches and pains due to commo…
The FDA has approved Children's Advil (ibuprofen) for over-the-counter use in children to reduce fever and relieve minor aches and pains. It…
FDA May 6, 2026
Parechovirus A detection linked to pharyngitis and tonsillitis in children across hospital and day-care settings
Pediatrics Cohort
Parechovirus A detection linked to pharyngitis and tonsillitis in children across hospital and day-care settings This common virus may be behind your child’s sore throat
This observational cohort study evaluated 323 hospitalized children and 30 day-care attendees for parechovirus A (PeV-A) alongside other res…
A common virus called PeV-A is linked to sore throats in kids and helps explain why some children get sick when others stay healthy.
Frontiers Apr 20, 2026

Questions about pharyngitis

Can parechovirus A cause pharyngitis and tonsillitis in hospitalized children?

Yes, parechovirus A can cause pharyngitis and tonsillitis in hospitalized children, especially when detected alone without other viruses.

Full answer →