Phase 4 N=375 Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis
Bacterial Meningitis
Primary: Day 7 Mortality — 61; 64 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=887 Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode.
Acute Heart Failure
Primary: N-terminal Pro-brain Natriuretic Peptide (NT-proBNP) Values and Time-averaged Change From Baseline — 0.7466; 0.5333 pg/ml — p=<.0001
Phase 4 N=100 Clinical Investigation of the Bi Flex M Multifocal IOL
Cataract
Primary: Long Term Monocular Visual Acuity (VA) — 0.192; 0.205; 0.614; 0.319 LogMAR
Phase 4 N=6,998 STudy to vAlidate telemetRic ECG Systems for firsT Dose Administration of Fingolimod (START)
Multiple Sclerosis
Primary: Participants With 2nd or 3rd Degree Atrioventricular (AV) Block — 120; 117; 0; 43 Participants
Phase 4 N=379 A Randomized, Multicenter, Open-label, Parallel-group, 12-week Study to Assess the Efficacy and Safety of Switching From Tiotropium to QVA149 (Indacaterol Maleate/Glycopyrronium Bromide) in Symptomatic Mild to Moderate COPD Patients
COPD
Primary: Trough Forced Expiratory Volume In One Second (FEV1) After 12 Weeks of Treatment — 0.0668; 0.0090 Liters — p=0.0129
Phase 4 N=61 Safety and Efficacy of Treatment With Azzalure, Restylane/Emervel Filler and Restylane Skinbooster
Facial Aesthetic Treatment
Primary: Number of Subjects With Improvement in Global Facial Aesthetic Appearance at 7 Months (Review of Photographs) — 20; 25 Participants
Phase 4 N=101 Deep Versus Moderate Muscle Relaxation During Laparoscopic Donor Nephrectomy in Enhancing Postoperative Recovery
Neuromuscular Block · Renal Transplant Donor of Left Kidney · Renal Transplant Donor of Right Kidney
Primary: Total Score of the Quality of Recovery-40 Questionnaire (QoR-40) — 169.3; 169.5 score on a scale
Phase 4 N=184 Omarigliptin Add-on to Insulin in Japanese Participants With Type 2 Diabetes Mellitus (T2DM, MK-3102-039)
Type 2 Diabetes Mellitus
Primary: Constrained Longitudinal Data Analysis of Change From Baseline in Hemoglobin A1c (HbA1c) at Week 16 Excluding Data After Glycemic Rescue (Phase A) — -0.61; 0.29 Percent…
Phase 4 N=21 Effect of CES on Parasympathetic Tone
Autonomic Nervous System Imbalance
Primary: Change in High Frequency Heart Rate Variability — 5.10; 5.14; 5.00; 5.12 Units on a Log Scale — p=<.02
Phase 4 N=401 Depo Provera Self-Administration Study: Putting a Patient-Centered Practice to the Test at Planned Parenthood
Contraception
Primary: Number of Participants With Depot Medroxyprogesterone Acetate (DMPA sc) Continuation at One Year by Self-report in Both the Self- and Clinic Administration Arms — 108…
Phase 4 N=87 P3AMI Antiplatelet Trial
Heart Attack
Primary: Pharmacodynamic Assessment of Degree of Platelet Inhibition as Determined by Verify Now Point of Care Assay and Expressed as P2Y12 Reaction Units (PRU) — 270.23; 247.73…
Phase 4 N=302 Managing Alcoholism in People Who Do Not Respond to Naltrexone
Alcoholism
Primary: Count of Responders and Non-responders in Phase 1 — 103; 80 Participants
Phase 4 N=161 Efficacy and Safety Study of Pitavastatin Compared to atoRvastatin in Type 2 dIabeTes Mellitus With Hypercholesterolemia
Hypercholesterolemia With Type2DM
Primary: Proportion of Patients Achieving LDL- C<100mg/dL — 61; 54 Participants
Phase 4 N=267 Examining Tolerance to CNS Stimulants in ADHD
Attention-deficit/Hyperactivity Disorder
Primary: Number of Dose Changes Required Per Protocol — 1.79; 1.61 Number of Increases
Phase 4 N=32 Nicotine Patch as an Adjunctive Intervention to Reduce Secondhand Smoke Among NICU Families
Environmental Tobacco Smoke · Smoking Cessation
Primary: Feasibility as Assessed by Number of Participants Who Accepted NRT Patches From Research Staff. — 13 Participants