N/A N=14 Pharmacotoxicology of Trichloroethylene Metabolites
Congenital Lactic Acidosis
Primary: Hypothesize That Subject's Genotype Will Determine How DCA is Metabolized. — 1592; 232 Minutes — p=0.023
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=7 Pharmacotoxicology of Trichloroethylene Metabolites
Healthy
Primary: Plasma DCA (Microgram/ml) After 5 Days of Therapeutic Level Chloral Hydrate on Arm 2A. — 1.64 micrograms/ml
N/A N=434 Personalized Mobile Intervention to Reduce Exposure to Endocrine Disrupting Chemicals in Adults of Child-Bearing Age
Endocrine Disrupting Chemicals · Environmental Exposure · Health Literacy
Primary: Changes in Endocrine Disrupting Chemical (EDC) Levels as Measured by the Post-intervention Value Minus the Baseline Value. — 5.83; 18.43; 56.94; 75.30 ng/ml — p=<0.05
N/A N=359 Novel Determinants and Measures of Smokeless Tobacco Use: Study 1
Smokeless Tobacco Use · Tobacco Dependence
Primary: Extent of Toxicity: Mean of Median Values of NNK+NNN in 7 Smokeless Tobacco Brands — 2.4; 2.25; 3.19; 5.51 ug/g
Phase 2 N=300 Clinical Trial of Two Study Drinks in Detoxification of Environmental Toxicants and Carcinogens
Healthy
Primary: Carcinogen Detoxification of Metabolites in Urine. — 7.26; 6.11; 3052.39; 1843.29 ng/mL
N/A N=102 European Survey: Risk of Cyanide Poisoning in Smoke Inhalation
Smoke Inhalation Patients
Primary: Overall Survival After 24 Hours — 96 participants
Early Phase 1 N=8 Benzo[a]Pyrene Ultralow Dose-Response Study
Environmental Exposure
Primary: Peak Plasma Concentration Cmax — 2.51; 5.68; 13.8; 8.99 fg [14C]-BaP/mL plasma
N/A N=299 Nucleophilic Defense Against PM Toxicity (NEAT Trial)
Air Pollution Toxicity
Primary: Endothelial Progenitor Cells — 0.0025; 0.0027 # cells per CD41 minus cells
Phase 4 N=60 A Preliminary Study of Choline and Betaine Supplementation Among Adults Exposed to Arsenic in Bangladesh
Arsenic Metabolites Measured in Urine
Primary: Change in Urinary % Monomethyl Arsenic — 2.4; 0.24; -0.06; -3.2 percentage of total urinary arsenic
N/A N=40 Measurement of Agricultural and Dietary Glyphosate Exposure Among Pregnant Women
Exposure to Herbicides
Primary: Specific Gravity-adjusted Urinary Glyphosate Concentrations During Conventional and Organic Diet — 0.19; 0.17; 0.18; 0.14 ug/L — p=0.17
Phase 1 N=26 Pharmacokinetic and Pharmacodynamic Effects of Passive Cannabis Inhalation
Cannabis Toxicology
Primary: Delta-9-tetrahydrocannabinol (THC) Cmax in Blood — 1.4; 3.07; 0.5 ng/mL
N/A N=987 Reducing Pesticide Exposures in Child Care Centers
Children, Only · Risk Reduction · Environmental Exposure
Primary: Decrease in Child Care Center Pesticides — 1.95; 1.87; 0.59; 0.53 log10(ng/g) — p=<0.05
Phase 2 N=36 In Vivo Assessment of Silver Biomaterial Nano-Toxicity
Healthy
Primary: Change in Sodium Blood Levels — -0.1; 0.2 mmol/L
Phase 2 N=170 Broccoli Sprout Dose Response: Bioavailability and Effects of Air Pollutants
Environmental Carcinogenesis
Primary: Sulforaphane Bioavailability Measured in Sequential 12-Hour Urine Samples — 24.8; 11.0; 4.3 micromoles/24 hours — p=<0.001
N/A N=85 Assessing Toxicity of Waterpipe Tobacco Smoking
Waterpipe Smoking
Primary: Comparing Cotinine Pre-to-post Change Between 2 Waterpipe Smoking Sessions: Heating Waterpipe Tobacco by (a) Charcoal vs (b) an Electric Head — 34.9; 26.4 ng/mL — p=0.115
Phase 4 N=20 PFAS Exposure and Immune Response to Vaccination in Adults
Innate Inflammatory Response · Vaccination · Diphtheria
Primary: Change in Tetanus-diphtheria Specific IgG by PFNA Exposure Category — 3.54; 3.39; 2.44; 2.43 log2(fold change) — p=.85
N/A N=50 Effects of Deployment Exposures on Cardiopulmonary and Autonomic Function
Abnormality, Respiratory System · Autonomic Nervous System
Primary: FEV1 — 0.94; 1.08; 0.95; 1.09 percentage of predicted normal values
N/A N=160 Reduced Exposure Study Using THS 2.2 Menthol With 5 Days in a Confinement Setting Followed by 86 Days in an Ambulatory Setting
Smoking
Primary: Concentration of Monohydroxybutenylmercapturic Acid (MHBMA) — 110.96; 882.25; 94.97 pg/mg creat — p=<0.001
Early Phase 1 N=8 Ultralow Dose PAH Binary Mixture Study
Environmental Exposure
Primary: Peak Plasma Concentration of 14C-BaP Cmax — 7.07; 1.60 fg [14C]-BaP/mL plasma
N/A N=163 Impacts of Clinician-Mediated Report-Back
Health Knowledge, Attitudes, Practice
Primary: Knowledge Before and After Report-back Intervention. — 0.06; 0.02 Scores on a scale
N/A N=10 Phthalate and Bisphenol Exposure During Minipuberty
Phthalate Exposure · Bisphenol Exposure
Primary: Log Signal Intensity of Bisphenol A (BPA) in Child Urine Samples — 0.00; 5.43 Log(Arbitrary Units)
N/A N=160 Reduced Exposure Study Using THS 2.2 Menthol With 5 Days in a Confinement Setting and 85 Days in an Ambulatory Setting
Smoking
Primary: Concentration of Monohydroxybutenyl Mercapturic Acid (MHBMA) — 83.21; 617.04; 83.57 pg/mg creat — p=<.001
Phase 1 N=38 Clinical Evaluation of the Phototoxic Potential of Xenaderm Ointment
Healthy
Primary: Skin Reaction Score — 0.4; 0.5; 0.1; 0.4 units on a scale
Early Phase 1 N=11 Ventilation and Pulmonary Endothelium Toxicities of E-cigarettes: A Randomized Crossover Pilot Study
Pulmonary Disease, Chronic Obstructive · E-cigarettes
Primary: Pulmonary Microvascular Blood Flow (PMBF), Measured on Gadolinium-enhanced MRI, Between E-cigarette Exposed and Unexposed Conditions — 74.4; 63.1 mL(blood)/min/mL(lung)…
Phase 2 N=234 Phase 2 Reduction of Dietary Mycotoxin Exposure by ACCS100"
Dietary Carcinogenesis
Primary: AFB1-lysine Adduct (pg/mg) Overtime — 3.77; 4.09; 4.26; 3.00 pg/mg albumin
Early Phase 1 N=28 Intervention to Reduce Body Burdens of PCBs in Residents of Anniston, Alabama
Toxic Effect of Other Corrosive Organic Compounds
Primary: Percent Change From Baseline for Total PCB Levels — 92; 96 % of baseline total PCBs
Phase 2 N=12 In-Vivo Assessment of Silver Biomaterial Nano-Toxicity 32 Ppm
Healthy
Primary: Change Sodium Blood Levels — 141.8; 141.2 mmol/L
N/A N=60 Health Effects of Diesel Exhaust in Asthmatic Patients: A Real-world Study in a London Street
Asthma
Primary: Spirometry, Percentage Change in FEV1 From Baseline — -1.0; -4.8; -2.2; -7.4 percentage change in FEV1 from baseline — p=<0.05
N/A N=268 Work Should Not Hurt You: Reduction of Hazardous Exposures in Small Businesses Through a Community Health Worker Intervention
Community Health Aides · Industrial Hygiene · Volatile Organic Compounds
Primary: Change in Volatile Organic Chemical Concentrations From Pre- to Post-Intervention — 2738; 3875; 523; 225 ppb
N/A N=28 Removal of Dermal Exposure to Phthalate Ester by Hand Washing
Environmental Exposure · Exposure to Pollution
Primary: Amount of Diethylhexyl Phthalate Removed From Hand — 94.64; 8.74 percentage of DEHP removed