Clinical Trial Search

Primary: Number of Reported Dose Limiting Toxicities (DLT) (Part A Only) — 0; 1; 1 dose-limiting toxicities

Primary: Change in Pain Visual Analogue Scale(VAS) — 5.91; 5.90; 4.73; 4.60 score on a scale

Primary: Quality of Surgery for Primary Tumor — 2; 1; 15; 19 Participants — p=0.719

Primary: Mean Difference in Change of Depressive Symptoms Using the Patient-Reported Outcomes Measurement Information System (PROMIS) -Depression Scale in Primary Central Nervous…

Primary: Completed MEG — 1 participants

Primary: Change From Baseline in Pediatric Anxiety Rating Scale (PARS) — -10.3 change in scale score

Primary: Change From Baseline Levels of Fecal Short-chain Fatty Acid (With a Particular Focus on Acetate) — 23.55; -13.9; -19.5; 7.25 micromolar

Primary: Pain During Cervical Dilation — 44; 50 millimeters on VAS

Primary: Phase 1: Number of Participants With Dose-limiting Toxicities (DLTs) — 0; 0; 0; 0 Participants

Primary: Change in Weight — -3; -3.5; -1.3 Kg

Primary: Time in Seconds to Complete the Cystourethroscopy — 103; 117; 147; 82 seconds

Primary: Pharmacokinetics (PK): Area Under the Concentration-Time Curve From Hour 0 to the Last Measurable Concentration (AUC0-t) of Midazolam and Its Metabolite…

Primary: Mean Score of the 6-point Modified Rankin Scale (mRS) at Visit 5 After Completion of the Course of Therapy for Both Arms — 1.098; 1.46 score on a scale

Primary: Freedom From Device/System Related Complications — 304 Participants

Primary: Procedural Success — 16; 9 Participants