65,437 trials
Transthyretin Amyloid Polyneuropathy (ATTR-PN)
Primary: Change From Baseline in Neuropathy Impairment Score-lower Limb (NIS-LL) Total Score at Week 72 — 2.3 Units on a scale
Healthy
Primary: Area Under the Curve (AUC) From Time 0 to 24 Hours Post-dose (AUC24h) for Vupanorsen — 3.649; 10.82 microgram*hour per milliliter(mcg*hr/mL)
Small for Gestational Age
Primary: Number of Participants With Development of Diabetes in Short Children Born SGA During Treatment — 0 Participants
Breast Cancer
Primary: Correlation Between Prone Breast MRI for Estimation of Tumor Size and Final Pathology Tumor Size — 0.635 correlation coefficient
Kidney Stone · Renal Stone · Infection, Bacterial
Primary: Incidence of Infection Post Surgery — 0; 7 participants
Hematopoietic and Lymphoid Cell Neoplasm · Malignant Solid Neoplasm
Primary: Clinical Outcome in the MITT Analysis Set at EOIV. — 44; 37; 5; 12 Participants
Foot Drop
Primary: Mean Dorsiflexion at Heel Strike — 5.2 degrees
Triple Negative Breast Cancer · Breast Cancer
Primary: Immune-based Mechanism of Action — 0.3 CD8+/Tregs ratio — p=0.101
Cancer · Patient Empowerment
Primary: Percentage of Participants Achieving Target Levels in Cancer Knowledge Using the Cancer Awareness Measurement Survey — 20 Participants
Olfactory Dysfunction · COVID-19
Primary: Change in University of Pennsylvania Smell Identification Test (UPSIT) Scores — 2.571; 3.182 score on a scale
Diabetes Mellitus, Type 2
Primary: Change in HbA1c From Baseline After 52 Weeks of Treatment — -0.12; -0.69 percentage of glycated hemoglobin — p=<0.0001
Acute Intermittent Porphyria
Primary: Percentage of Participants With Adverse Events (AEs) — 100 percentage of participants
Influenza, Human
Primary: Percentage of Participants Reporting Local Reactions After Vaccination 1: Substudy A — 0; 0; 0; 0 Percentage of participants
B Acute Lymphoblastic Leukemia · B Acute Lymphoblastic Leukemia, BCR-ABL1-Like · Central Nervous System Leukemia
Primary: DFS of Non-DS HR Post-induction Patients Receiving Intrathecal (IT) Methotrexate (MTX) Compared With Patients Receiving Intrathecal Triple Therapy (ITT) on a Modified…
Beliefs
Primary: Change in Accuracy of Belief That Nicotine Causes Cancer — 52.6; 54.0; 39.2; 36.1 units on a scale — p=0.095