Clinical Trial Search

Primary: Fraction of Time That Brain Oxygen Levels Are Below the Critical Threshold of 20 mm Hg . — 0.15; 0.44 Proportion

Primary: Participation Assessment With Recombined Tools - Objective 17 (PART-O-17) — 1.30; 1.33 units on a scale — p=0.44

Primary: The Feasibility of Inpatient Bedside Neurocognitive Testing of Pediatric Patients With Minor Traumatic Brain Injury. — 120 participants

Primary: Percent Change in Trail Making Test Part B Time to Completion — -25.6 percent change in time

Primary: Number of Participants With Improved Cerebral Perfusion — 8 Participants

Primary: Change From Baseline on a Composite Measure (Z-score) of Attention, Working Memory, and Executive Functions — 0.26; .01 Change to Z (composite) score

Primary: Change in Vitals at Visit 2 — 0 Participants

Primary: Cerebral Blood Flow Velocity in the Left (L) and Right (R) Middle Cerebral Artery (MCA), Internal Carotid Artery (ICA), and Basilar Artery (BA). — 3.2; 6.7; 4; 12.7 ml/sec

Primary: Self-report — 7.79; 6.49; 7.61; 7.73 units on a scale

Primary: Performance on Trail-making Test, Part B — -0.02; 0.18 z-score — p=< 0.04

Primary: Change From Baseline of Concentrations of Essential Amino Acid at 1.5 Hours After Eating — 487.28; 553.70; 1224.19; 1339.54 µM

Primary: Longitudinal DTI Changes — 0.000809; 0.000760; 0.000763; 0.000843 voxels

Primary: Percentage of Critically Ill Patients With Acute Brain Injury Achieving Pre-specified Feasibility Criteria — 0; 87.5; 0 percentage of patients

Primary: Performance on Multiple Sleep Latency Test (MSLT) — 6.67; 7.32; 6.73; 7.88 minutes

Primary: 4 Hour Mortality — 50; 32 Participants

Primary: Change in Number of Headache Days — -8; -6 headache days

Primary: Computer Cognitive Test Scores - ImPACT Verbal Memory — 70.48; 74.21; 78.12; 75.36 units on a scale

Primary: Memory Test Accuracy on Trained Stimuli — 53.9; 37.6; 48.9; 37.3 Percent correct

Primary: Percent Passing the Galveston Orientation Amnesia Test (GOAT) Within 28 Days Post Injury — 12; 14 Participants — p=0.99

Primary: Change in Quality of Life as Measured by the Short Form-36 (SF-36) — 47.97 score on a scale

Primary: Composite Score of Attention and Executive Functioning From a Neurocognitive Test Battery — 0.18; -0.06 units on a scale

Primary: Sensitivity: Percentage of MRIs Correctly Identifying Clinically Important Intracranial Injury (True Positives) — 70 Percentage of MRIs correctly identifying

Primary: Glasgow Coma Scale (GCS) — 3.14; 3.11; 4.67 units on a scale

Primary: Percentage of Participants With Worsening TBI Hemorrhage — 5.9; 3.6 percentage of participants

Primary: PaO2 — 115; 95 mmHg — p=<0.05

Primary: Functional Independence Measure Scores — 88.11; 89.79; 120.57; 119.67 units on a scale

Primary: Change in Executive Functioning as Assessed by the Trail Making Test — -9.2; 24.7 change in seconds — p=.323

Primary: MRI Image Data Sets — 79; 150; 290; 111 Images collected

Primary: Functional Outcome 6 Months After Injury, as Measured by the Processing Speed Index — 82.5; 82.5 Processing speed index standardized scor

Primary: Glasgow Outcome Scale (GOS) — 189; 183; 109; 114 Participants