Phase 4 N=32 Angiotensin II in General Anesthesia
Hypertension
Primary: Median Dose Required to Increase the Systolic Blood Pressure (SBP) — 35; 43; 45 ng/kg/min
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=214 Hypotension Prediction Index for Blood Pressure Management
Intraoperative Hypotension
Primary: Time- Weighted Average (TWA) MAP Under a Threshold of 65 mmHg. — 0.14; 0.14 mmHg — p=0.757
Phase 3 N=66 Treatment of Post-SCI Hypotension
Spinal Cord Injury · Autonomic Dysreflexia · Orthostatic Hypotension
Primary: Affected Therapy Sessions — 16.4; 10.9 percentage of sessions
N/A N=356 Orthostatic Hypotension Treatment on Rehab Unit
Orthostatic Hypotension · Falls
Primary: Orthostatic Hypotension at Discharge — 39; 44 Participants — p=0.6
N/A N=14 Blood Volume Analysis of Total Hip Arthroplasty Patients Under Hypotensive Anesthesia
Blood Volume Analysis
Primary: Change in Total Blood Volume — 487 ml
Phase 3 N=321 A Phase 3 Study of LJPC-501 in Patients With Catecholamine-Resistant Hypotension
Catecholamine-resistant Hypotension (CRH) · Distributive Shock · High Output Shock
Primary: An Increased MAP, Defined as Achievement of a Day 1 MAP at 3 Hours Following the Initiation of Study Drug, of ≥ 75 mmHg OR a 10 mmHg Increase in Baseline MAP — 114; 37…
Phase 3 N=136 Midodrine for the Treatment of Refractory Hypotension
Hypotension · Critical Illness
Primary: Time Until Discontinuation of IV Vasopressors — 23.5; 22.5 hours
Phase 2 N=66 The Prevention of Hypotension After Epidural Analgesia After Major Surgery
Hypotension · Pain
Primary: Changes Between the 3 Groups Assessed by Blood Pressure Measurement — 5; 2; 3; 10 Participants — p=0.165
Phase 1 N=20 Intravenous AII for the Treatment of Severe Hypotension in High Output Shock: A Pilot Study
Septic Shock
Primary: Standing Dose of Norepinephrine Which is Required to Maintain a Mean Arterial Pressure (MAP) of 65 mmHg - Hour 1 — 7.4; 27.6 mcg/min
N/A N=35 The Effect of Hypotensive Anesthesia on Hemoglobin Levels During Total Knee Arthroplasty
Anesthesia
Primary: The Hemoglobin (in g/dl) Levels — 12.2; 12.0; 11.9; 11.8 g/dl
N/A N=133 Evaluating the Effect of Chronic Antihypertensive Therapy on Vasopressor Dosing in Septic Shock
Septic Shock
Primary: Total Vasopressor Dose — 13.7; 13.1; 13.2; 11.3 mg
Phase 2 N=21 The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury
Spinal Cord Injury · Autonomic Dysreflexia · Baroreceptor Integrity
Primary: Systolic Blood Pressure — 93.21; 107.00; 95.8; 93.84 mmHg
N/A N=102 Leg Elevation to Prevent Hypotension During Labor
Hypotension · Labor Complication
Primary: Number of Patients With Maternal Hypotension Requiring Treatment — 6; 11; 48; 27 Participants
N/A N=146 The Effect of Pre-discharge Blood Pressure of Patients With Asymptomatic Severe Hypertension in Emergency Department
Hypertension · Emergencies · Asymptomatic Conditions
Primary: Number of Participants Who Died Within 7 Days After Discharge From the Emergency Department — 0; 0 participants
Phase 4 N=337 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation
Acute Respiratory Failure · Intubation Complication
Primary: Number of Participants With Cardiovascular Collapse — 33; 31 Participants
Phase 2 N=191 Field Trial of Hypotensive Versus Standard Resuscitation for Hemorrhagic Shock After Trauma
Blunt Trauma · Penetrating Wound · Hemorrhagic Shock
Primary: Total Volume of All Crystalloid Given for Early Resuscitation (Feasibility) — 2.04; 1.04; 1 liters
Phase 2 N=10 Acetylcholinesterase Inhibition and Orthostatic Hypotension in SCI
Hypotension, Postural
Primary: Systolic Blood Pressure — 97; 103; 90; 88 mm Hg
Phase 2 N=47 Efficacy Study of a Facemask Device to Treat Hypotension
Hypotension
Primary: Rise in Systolic Blood Pressure Over the First 10 Minutes of Use Compared to Baseline — 5.9; 12.9 mm Hg
N/A N=34 Hypotension Prediction Index to Predict Epidural-labor Analgesia Induced Hypotension
Anesthesia, Epidural · Hypotension
Primary: Time-to-treatment of Hypotension (Minutes) — 21.8; 23.1 minutes
Phase 4 N=3,626 Norepinephrine vs Phenylephrine During General Anesthesia
Anesthesia · Surgery · Hypotension
Primary: Number of Participants With Assigned Vasopressor Given — 1570; 1627 Participants
N/A N=70 Study of Dopamine Versus Vasopressin for Treatment of Low Blood Pressure in Low Birth Weight Infants
Hypotension
Primary: Number of Subjects in Each Group Who Have Achieved an Optimal Mean Blood Pressure Value at 24 Hours of Life — 9; 9 participants
N/A N=17,463 Decision Support for Intraoperative Low Blood Pressure
Hypotension
Primary: Postoperative Acute Kidney Injury — 1333; 372; 9670; 2785 Participants
Phase 2 N=52 Mannitol - Potential Role in Hemodialysis Initiation for Reduction of Intra-dialytic Hypotension
Intra-dialytic Hypotension
Primary: Efficacy of Mannitol Administration in Reducing the Frequency of Intra-dialytic Hypotension (Decline in Systolic Blood Pressure) During the First Three Hemodialysis…
Phase 2 N=384 Furosemide for Accelerated Recovery of Blood Pressure Postpartum
Hypertension, Pregnancy-Induced
Primary: Persistently Elevated Blood Pressures 7 Days Postpartum — 10; 23 Participants — p=0.03
Phase 2 N=11 A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride
Orthostatic Hypotension · Spinal Cord Injury
Primary: Systolic Blood Pressure — 98; 97; 102; 87 mmHg
Phase 2 N=6 Intravenous Norepinephrine for Orthostatic Hypotension
Orthostatic Hypertension
Primary: Blood Pressure (Systolic) — 156; 158; 179; 148 mm Hg
N/A N=139 Trial of Dialysate Sodium in Chronic Hospitalized Hemodialysis Patients
Intra-dialytic Hypotension
Primary: Change in Intra-dialytic Decline in Systolic Blood Pressure — 26; 23 mm Hg
N/A N=341 Orthostatic Hypotension in Rehabilitation Patients
Hypotension, Orthostatic
Primary: Orthostatic Hypotension at Discharge — 96 participants
Phase 3 N=12 Hydrocortisone for Term Hypotension
Infant, Newborn, Diseases · Cardiovascular Insufficiency
Primary: Death — 6; 6; 0; 0 Participants
N/A N=22 Local Heat Stress in Autonomic Failure Patients With Supine Hypertension
Hypertension · Pure Autonomic Failure · Multiple System Atrophy
Primary: Change in Systolic Blood Pressure — 19; 3 mm Hg